Endothelin-1 stimulates tyrosine phosphorylation of p125 focal adhesion kinase in mesangial cells. [PDF]
Journal of the American Society of Nephrology, 1995 Endothelin-1 (ET-1) is known to induce the contraction and proliferation of glomerular mesangial cells. Because ET-1 was found to stimulate the tyrosine phosphorylation of unidentified cellular proteins in cultured mesangial cells, protein tyrosine kinase might serve as one of the important signals leading to various functions of ET-1.
M, Haneda +6 more
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Scientific Reports, 2021 Stroke is a multiphasic process involving a direct ischemic brain injury which is then exacerbated by the influx of immune cells into the brain tissue. Activation of brain endothelial cells leads to the expression of adhesion molecules such vascular cell
Lori N. Eidson +12 more
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, 2011 Focal adhesion kinase plays a critical role in cancer progression, invasion, and metastasis. Although focal adhesion kinase overexpression indicates poor prognoses for hepatocellular carcinoma, its role in hepatocellular carcinoma metastasis has not been
詹以吉;柯博升;許駿;王約翰;劉俊揚 +1 more
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Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts. [PDF]
PLoS ONE, 2017 A hypoxic stress which causes apoptosis of cardiomyocytes is the main problem in the ischemic heart disease. Canstatin, a non-collagenous fragment of type IV collagen α2 chain, is an endogenous anti-angiogenic factor.
Hiroki Kanazawa +3 more
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Dissecting interactions within focal adhesions: studies on vinculin
, 2008 Vinculin and paxillin are proteins that localise to focal adhesions. Focal adhesions arespecialised sites of cell attachment between the cytoplasmic side of the cell membrane andthe extracellular matrix.
Cox, Clare Louise
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Role of the Ste20‐like kinase SLK in podocyte adhesion
Physiological ReportsSLK controls the cytoskeleton, cell adhesion, and migration. Podocyte‐specific deletion of SLK in mice leads to podocyte injury as mice age and exacerbates injury in experimental focal segment glomerulosclerosis (FSGS; adriamycin nephrosis).
Andrey V. Cybulsky +4 more
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Novel pharmacologic targeting of tight junctions and focal adhesions in prostate cancer cells.
PLoS ONE, 2014 Cancer cell resistance to anoikis driven by aberrant signaling sustained by the tumor microenvironment confers high invasive potential and therapeutic resistance.
Patrick J Hensley +5 more
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Galectin-3 Overrides PTRF/Cavin-1 Reduction of PC3 Prostate Cancer Cell Migration. [PDF]
PLoS ONE, 2015 Expression of Caveolin-1 (Cav1), a key component of cell surface caveolae, is elevated in prostate cancer (PCa) and associated with PCa metastasis and a poor prognosis for PCa patients.
Fanrui Meng +2 more
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Solid Phase Peptide Synthesis: Analysis and Identification of Protein Kinase Substrates [PDF]
, 2005 This research study examines the synthesis of tyrosine containing peptides based on the protein paxillin. Paxillin is a proposed substrate of the Focal Adhesion Kinase (FAK) protein tyrosine kinase.
Kroodsma, Derrick
core
Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes [PDF]
, 2007 Adhesion molecules of the integrin beta1 family are thought to be involved in the malignant progression renal cell carcinoma (RCC). Still, it is not clear how they contribute to this process.
Jones, Jon +15 more
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