Results 51 to 60 of about 113,919,521 (303)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Open Bio, 2016 Lysophophatidylcholine (LysoPC) is an abundant constituent in human plasma. Patients with malignant cancer diseases have attenuated LysoPC plasma levels, and thus LysoPC has been examined as a metabolic biomarker for cancer prediction.
Thomas Ross +6 more
doaj +1 more source
Supplementary Figure 1 from Focal Adhesion Kinase Promotes the Aggressive Melanoma Phenotype
, 2023 Supplementary Figure 1 from Focal Adhesion Kinase Promotes the Aggressive Melanoma ...
Mary J.C. Hendrix +7 more
openaire +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Cells, 2019 Human palatine tonsils are potential tissue source of multipotent mesenchymal stem cells (MSCs). The proliferation rate of palatine tonsil-derived MSCs (TMSCs) is far higher than that of bone marrow-derived MSCs (BMSCs) or adipose tissue-derived MSCs ...
Gi Cheol Park +9 more
doaj +1 more source
Physiologic Role of Decidual .BETA.1 Integrin and Focal Adhesion Kinase in Embryonic Implantation
Endocrine Journal, 2003 Implantation refers to a series of interactions between embryo and endometrium including hatching, attachment, and outgrowth. We investigated the expression and function of beta1 integrin and focal adhesion kinase (FAK) in human decidual cells during implantation.
HANASHI, HIDEKI +9 more
openaire +3 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs
Scientific Reports, 2021 Focal adhesion kinase (FAK) localizes to focal adhesions and is overexpressed in many cancers. FAK can also translocate to the nucleus, where it binds to, and regulates, several transcription factors, including MBD2, p53 and IL-33, to control gene ...
Billie G. C. Griffith +7 more
doaj +1 more source
International Journal of Oncology, 2012 Studies suggest a tumor-promoting function of sphingosine kinase 1 (SphK1) in some types of human tumors, however, its effect on colon cancer is still unclear. The aims of this study were to investigate the roles of SphK1 in the progression and tumor cell phenotypic changes in colon cancer.
Shi-Quan, Liu +5 more
openaire +3 more sources
A FAK conundrum is solved: activation and organization of focal adhesion kinase at the plasma membrane [PDF]
, 2020 Focal adhesion kinase (FAK) is a central mediator of cell adhesion, acting both as a scaffold and as catalytically active kinase. Acebronet al(2020) use cryo-electron microscopy (cryo-EM) to visualize the dramatic structural changes that occur ...
Brod, F. +3 more
core +1 more source