Results 71 to 80 of about 113,919,521 (303)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Insulin and insulin-like growth factor-1 stimulate dephosphorylation of paxillin in parallel with focal adhesion kinase [PDF]

Biochemical Journal, 1996
Paxillin and focal adhesion kinase (pp125FAK) co-localize in focal adhesions; recently insulin has been shown to stimulate the dephosphorylation of pp125FAK; however, its effect on paxillin is unknown. We show that insulin and IGF-1 can stimulate the dephosphorylation of paxillin in CHOT (overexpress human insulin receptors) and CHO∆CT69 (overexpress ...
N, Konstantopoulos, S, Clark
openaire   +2 more sources

A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration [PDF]

, 2015
Fascin is an actin-binding and bundling protein that is highly upregulated in most epithelial cancers. Fascin promotes cell migration and adhesion dynamics in vitro and tumour cell metastasis in vivo.
Stramer, Brian M., Parsons, Maddy; id_orcid, Frame, Margaret, Bryan Serrels, Serrels, B, Parsons, M., Asier Jayo, Goult, B. T., Jayo, A., Zanet, J., Villari, G., Villari, G, Fitch, B., Serrels, Bryan, Stramer, BM, Fitch, Briana, Goult, Benjamin T., Frame, M., Jennifer Zanet, Frame, M, Jayo, Asier, Goult, Benjamin T, Briana Fitch, Brian M. Stramer, Margaret Frame, Fitch, B, Stramer, B. M., Jayo, A, Zanet, Jennifer, Serrels, B., Maddy Parsons, Parsons, M, Giulia Villari, Zanet, J, Benjamin T. Goult, Villari, Giulia, Stramer, Brian M, Parsons, Maddy   +37 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impaired Expression of Focal Adhesion Kinase in Mesenchymal Stromal Cells from Low-Risk Myelodysplastic Syndrome Patients

Frontiers in Oncology, 2017
The pathogenic role of mesenchymal stromal cells (MSCs) in myelodysplastic syndromes (MDS) development and progression has been investigated by numerous studies, yet, it remains controversial in some aspects (1, 2).
Yuenv Wu, Yuenv Wu, Carmen Mariana Aanei, Carmen Mariana Aanei, Sanae Kesr, Sanae Kesr, Tiphanie Picot, Tiphanie Picot, Denis Guyotat, Denis Guyotat, Lydia Campos Catafal, Lydia Campos Catafal   +11 more
doaj   +1 more source

Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells

Cell Reports, 2023
Summary: Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia.
Weiwei Xu, M.M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Siva S.V.P. Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Matthew J. Merrins, Debbie C. Thurmond, Ernesto Bernal-Mizrachi, David J. Hodson, Franck Mauvais-Jarvis   +34 more
doaj   +1 more source

Myofibroblast Differentiation by Transforming Growth Factor-ॆ1 Is Dependent on Cell Adhesion and Integrin Signaling via Focal Adhesion Kinase [PDF]

Journal of Biological Chemistry, 2003
Myofibroblast differentiation and activation by transforming growth factor-beta1 (TGF-beta1) is a critical event in the pathogenesis of human fibrotic diseases, but regulatory mechanisms for this effect are unclear. In this report, we demonstrate that stable expression of the myofibroblast phenotype requires both TGF-beta1 and adhesion-dependent ...
Victor J, Thannickal, Daniel Y, Lee, Eric S, White, Zongbin, Cui, Jose M, Larios, Raquel, Chacon, Jeffrey C, Horowitz, Regina M, Day, Peedikayil E, Thomas   +8 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Adhesion-derived condensates control component availability to regulate adhesion dynamics

Nature Communications
Integrin adhesion complexes mediate dynamic cell-matrix interactions to regulate cell adhesion, migration and invasion. While increasing evidence suggests that adhesion components can undergo liquid-liquid phase separation, the functional relevance of ...
Michal Dibus, Megan R. Chastney, Giray Enkavi, Gautier Follain, Omkar Joshi, Ilpo Vattulainen, Johanna Ivaska   +6 more
doaj   +1 more source

CAR Co-Operates With Integrins to Promote Lung Cancer Cell Adhesion and Invasion

Frontiers in Oncology, 2022
The coxsackie and adenovirus receptor (CAR) is a member of the junctional adhesion molecule (JAM) family of adhesion receptors and is localised to epithelial cell tight and adherens junctions.
Claudia Owczarek, Elena Ortiz-Zapater, Elena Ortiz-Zapater, Jana Kim, Efthymia Papaevangelou, George Santis, Maddy Parsons   +6 more
doaj   +1 more source