Results 91 to 100 of about 145,198 (308)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Role of Focal Adhesion Kinase in Sphingosine‐1‐Phosphate Induced Endothelial Barrier Enhancement

The FASEB Journal, 2008
Dynamic interactions between adherens junctions and cell‐matrix adhesions mediated by actin cytoskeleton regulate endothelial barrier function. Barrier‐enhancing agonist, sphingosine‐1‐phosphate (S1P), by binding its S1P receptor1 (S1P‐1) on the endothelial cell surface enhance endothelial monolayer integrity by Rac1‐mediated stabilization of ...
Tracy Lynn Thennes, Maria Konstantoulaki, Dolly Mehta   +2 more
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Myofibroblast Differentiation by Transforming Growth Factor-ॆ1 Is Dependent on Cell Adhesion and Integrin Signaling via Focal Adhesion Kinase [PDF]

Journal of Biological Chemistry, 2003
Myofibroblast differentiation and activation by transforming growth factor-beta1 (TGF-beta1) is a critical event in the pathogenesis of human fibrotic diseases, but regulatory mechanisms for this effect are unclear. In this report, we demonstrate that stable expression of the myofibroblast phenotype requires both TGF-beta1 and adhesion-dependent ...
Victor J, Thannickal, Daniel Y, Lee, Eric S, White, Zongbin, Cui, Jose M, Larios, Raquel, Chacon, Jeffrey C, Horowitz, Regina M, Day, Peedikayil E, Thomas   +8 more
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The Increase of pFAK and THBS1 Protein and Gene Expression Levels in Vascular Smooth Muscle Cells by Histamine-treated M1 Macrophages

Iranian Journal of Allergy, Asthma and Immunology, 2019
Atherosclerosis is developed due to the formation of atheroma plaques in the coronary arteries. In this process, M1 macrophages and vascular smooth muscle cells (VSMCs) are the main functional cells.
Mohsen Khosravi, Mohammad Najafi, Abdollah Amirfarhangi, Mahdi Karimi, Fahimeh Fattahi, Mohammad Shabani   +5 more
doaj   +1 more source

Acoustic Tweezing Cytometry Induces Rapid Initiation of Human Embryonic Stem Cell Differentiation. [PDF]

, 2018
Mechanical forces play critical roles in influencing human embryonic stem cell (hESC) fate. However, it remains largely uncharacterized how local mechanical forces influence hESC behavior in vitro.
Deng, Cheri X, Fan, Zhenzhen, Fu, Jianping, Hong, Xiaowei, Kanetkar, Ninad, Krebsbach, Paul H, Nguyen, Joe T, Topal, Tuğba, Xue, Xufeng   +8 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Therapeutic effects of tyroservatide on metastasis of lung cancer and its mechanism affecting integrin–focal adhesion kinase signal transduction

Drug Design, Development and Therapy, 2016
Yu-ting Huang,1,* Lan Zhao,1,* Zheng Fu,1 Meng Zhao,1 Xiao-meng Song,1 Jing Jia,1 Song Wang,1 Jin-ping Li,1 Zhi-feng Zhu,1 Gang Lin,1,2 Rong Lu,1,2 Zhi Yao1,3 1Department of Immunology, Tianjin Medical University, Tianjin, 2Shenzhen Kangzhe ...
Huang YT, Zhao L, Fu Z, Zhao M, Song XM, Jia J, Wang S, Li JP, Zhu ZF, Lin G, Lu R, Yao Z   +11 more
doaj  

Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis

Food and Agricultural Immunology, 2019
Osteoarthritis (OA) commonly affects the synovial joint and is characterized by degradation of articular cartilage, which is largely mobilized by increased matrix metalloproteinase (MMP) activity.
Shan-Chi Liu, Chun-Hao Tsai, Tung-Ying Wu, Chang-Hai Tsai, Fuu-Jen Tsai, Jing-Gung Chung, Chih-Yang Huang, Jai-Sing Yang, Yuan-Man Hsu, Mei-Chin Yin, Yang-Chang Wu, Chih-Hsin Tang   +11 more
doaj   +1 more source