Results 111 to 120 of about 113,919,521 (303)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Focal Adhesion Kinase Stabilizes the Cytoskeleton

, 2011
Focal adhesion kinase (FAK) is a central focal adhesion protein that promotes focal adhesion turnover, but the role of FAK for cell mechanical stability is unknown.
Wolfgang H. Goldmann, Sandra Kienle, Kienle, Sandra, Ben Fabry, Tilman E. Schäffer, Anna H. Klemm, Schäffer, Tilman E, Fabry, Ben, Goldmann, Wolfgang H, Klemm, Anna H   +9 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Fak silencing impairs osteogenic differentiation of bone mesenchymal stem cells induced by uniaxial mechanical stretch

Journal of Dental Sciences, 2019
Background/purpose: Mechanical stretch plays a key role in promoting proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs) in distraction osteogenesis (DO).
Pei Hu, Xiaowen Zhu, Chuang Zhao, Jing Hu, En Luo, Bin Ye   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion.

PLoS ONE, 2010
BackgroundHematopoietic progenitor kinase 1 (HPK1) is a Ste20-related serine/threonine kinase activated by a range of environmental stimuli including genotoxic stress, growth factors, inflammatory cytokines and antigen receptor triggering.
Sebastian Königsberger, Doris Peckl-Schmid, Nadja Zaborsky, Irene Patzak, Friedemann Kiefer, Gernot Achatz   +5 more
doaj   +1 more source

Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling

, 2016
Metastasis is a complex process that is regulated by multiple signaling pathways, with the focal adhesion kinase (FAK)/paxillin pathway playing a major role in the formation of focal adhesions and cell motility.
Sahni, Sumit, Wangpu, Xiongzhi, Xi, Ruxing, Menezes, Sharleen, Huang, Michael LH, Kovacevic, Zaklina, Park, Kyung Chan, Lu, Jiaoyang, Yue, Fei, Richardson, Des R, Zheng, Minhua   +10 more
core   +1 more source

ß1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli [PDF]

, 2005
Integrins are cell adhesion receptors which mediate interactions between the extracellular matrix and the actin cytoskeleton. They are heterodimers composed of α and β subunits. As adhesion receptors, integrins are important for cell-cell and cell-matrix
Li, Na
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Targeting the integrin beta 1‐focal adhesion kinase axis with artemisinin: Biophysical disruption of cell adhesion, migration, and invasion in tongue cancer

View
Tongue cancer is a significant threat to human health due to its propensity to spread throughout the oral cavity and to other regions of the head and neck.
Laurensia Danis Anggradita, Joo Hyun Kim, Min‐Kyu Kim, Ji Won Son, Mohd Farhan, Jothilin Subitsha Alex Jeberson, Ali Taghizadeh, Hae‐Won Kim, Jae Hong Park, Jaemoon Yang, Hyung Kwon Byeon, Sung Sik Hur, Myung Jin Ban, Yongsung Hwang   +13 more
doaj   +1 more source