Results 31 to 40 of about 83,211 (264)
Cell Adhesion & Migration, 2019 PEAR1 is highly expressed at bovine MDSC differentiation. However, its biological function remains unclear. Western blotting results showed that PEAR1 increased between day 0 and day 2 of cell differentiation and decreased from day 3.
Yusheng Pang +6 more
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TGFβ1 activates c-Jun and Erk1 via αVβ6 integrin
Molecular Cancer, 2003 Transforming growth factor β (TGFβ) plays an important role in animal development and many cellular processes. A variety of cellular functions that are required for tumor metastasis are controlled by integrins, a family of cell adhesion receptors ...
Schmidt Christian, Luettich Karsta
doaj +1 more source
Endothelin-1 stimulates tyrosine phosphorylation of p125 focal adhesion kinase in mesangial cells. [PDF]
Journal of the American Society of Nephrology, 1995 Endothelin-1 (ET-1) is known to induce the contraction and proliferation of glomerular mesangial cells. Because ET-1 was found to stimulate the tyrosine phosphorylation of unidentified cellular proteins in cultured mesangial cells, protein tyrosine kinase might serve as one of the important signals leading to various functions of ET-1.
M, Haneda +6 more
openaire +2 more sources
RIOK3 promotes pancreatic ductal adenocarcinoma cell invasion and metastasis by stabilizing FAK
Heliyon, 2022 Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive cancer, characterized by a high metastatic burden. RIO Kinase 3 (RIOK3) has been shown to promote invasion and metastasis of PDAC by cytoskeleton remodeling, but the exact mechanism is ...
Mengyuan Xu +6 more
doaj +1 more source
Scientific Reports, 2021 Stroke is a multiphasic process involving a direct ischemic brain injury which is then exacerbated by the influx of immune cells into the brain tissue. Activation of brain endothelial cells leads to the expression of adhesion molecules such vascular cell
Lori N. Eidson +12 more
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Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts. [PDF]
PLoS ONE, 2017 A hypoxic stress which causes apoptosis of cardiomyocytes is the main problem in the ischemic heart disease. Canstatin, a non-collagenous fragment of type IV collagen α2 chain, is an endogenous anti-angiogenic factor.
Hiroki Kanazawa +3 more
doaj +1 more source
Role of the Ste20‐like kinase SLK in podocyte adhesion
Physiological ReportsSLK controls the cytoskeleton, cell adhesion, and migration. Podocyte‐specific deletion of SLK in mice leads to podocyte injury as mice age and exacerbates injury in experimental focal segment glomerulosclerosis (FSGS; adriamycin nephrosis).
Andrey V. Cybulsky +4 more
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Supplementary Figure 1 from Focal Adhesion Kinase Promotes the Aggressive Melanoma Phenotype
, 2023 Supplementary Figure 1 from Focal Adhesion Kinase Promotes the Aggressive Melanoma ...
Mary J.C. Hendrix +7 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Novel pharmacologic targeting of tight junctions and focal adhesions in prostate cancer cells.
PLoS ONE, 2014 Cancer cell resistance to anoikis driven by aberrant signaling sustained by the tumor microenvironment confers high invasive potential and therapeutic resistance.
Patrick J Hensley +5 more
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