The Neurod1/4-Ntrk3-Src pathway regulates gonadotrope cell adhesion and motility
Cell Death Discovery, 2023 Pituitary gonadotrope cells are essential for the endocrine regulation of reproduction in vertebrates. These cells emerge early during embryogenesis, colonize the pituitary glands and organize in tridimensional networks, which are believed to be crucial ...
Charles Le Ciclé +8 more
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2001 Focal adhesion kinase (FAK) is known to be located at the intersection between extracellular matrix and growth factor signaling pathways to regulate cell motility. We have shown previously that an activated form (BCR-FLTm1) of Flt-1 kinase, a receptor for vascular endothelial growth factor, had a tubulogenic activity not only in endothelial cells but ...
Maru, Yoshiro +2 more
openaire +2 more sources
ADAM15 modulates outside-in signalling in chondrocyte–matrix interactions [PDF]
, 2008 ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions.
Böhm, Beate B. +5 more
core +1 more source
Insulin Receptor Substrate-1 as a Signaling Molecule for Focal Adhesion Kinase pp125FAK and pp60 [PDF]
Journal of Biological Chemistry, 1998 Insulin receptor substrate-1 (IRS-1) is a major substrate of insulin and insulin-like growth factor-I receptors, which upon phosphorylation on tyrosine docks several signaling molecules. Recently, IRS-1 was found to interact with alphav beta3 integrins upon insulin stimulation.
P, Lebrun +4 more
openaire +2 more sources
Mechanotransduction in striated muscle via focal adhesion kinase [PDF]
, 2007 Contractile tissues demonstrate a pronounced capacity to remodel their composition in response to mechanical challenges. Descriptive evidence suggests the upstream involvement of the phosphotransfer enzyme FAK (focal adhesion kinase) in the molecular ...
M Flück +19 more
core +1 more source
Caveolin-1 Up-regulation during Epithelial to Mesenchymal Transition Is Mediated by Focal Adhesion Kinase [PDF]
Journal of Biological Chemistry, 2008 Emerging evidence has shown that caveolin-1 is up-regulated in a number of metastatic cancers and can influence various aspects of cell migration. However, in general, the role of caveolin-1 in cancer progression is poorly understood. In the present study, we examined alterations in caveolin-1 expression during epithelial-to-mesenchymal transition (EMT)
Kelly M, Bailey, Jun, Liu
openaire +2 more sources
A role for Syk-kinase in the control of the binding cycle of the β2 integrins (CD11/CD18) in human polymorphonuclear neutrophils [PDF]
, 2003 A fine control of β2 integrin (CD11/CD18)-mediated firm adhesion of human neutrophils to the endothelial cell monolayer is required to allow ordered emigration.
Walzog, Barbara +4 more
core +1 more source
Modelling stromal FAK regulation of tumour growth, angiogenesis and progression [PDF]
, 2012 PhDThe growth of tumours within a whole organism depends on the tumour microenvironment. This involves both resident stromal cells, such as endothelial cells and fibroblasts, and also bone marrow derived stromal cells.
Batista, Silvia
core +2 more sources
TGFβ1 activates c-Jun and Erk1 via αVβ6 integrin
Molecular Cancer, 2003 Transforming growth factor β (TGFβ) plays an important role in animal development and many cellular processes. A variety of cellular functions that are required for tumor metastasis are controlled by integrins, a family of cell adhesion receptors ...
Schmidt Christian, Luettich Karsta
doaj +1 more source
RIOK3 promotes pancreatic ductal adenocarcinoma cell invasion and metastasis by stabilizing FAK
Heliyon, 2022 Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive cancer, characterized by a high metastatic burden. RIO Kinase 3 (RIOK3) has been shown to promote invasion and metastasis of PDAC by cytoskeleton remodeling, but the exact mechanism is ...
Mengyuan Xu +6 more
doaj +1 more source