Results 11 to 20 of about 145,198 (308)

MEK Kinase 1 Interacts with Focal Adhesion Kinase and Regulates Insulin Receptor Substrate-1 Expression [PDF]

Journal of Biological Chemistry, 2003
MEK kinase 1 (MEKK1) has been shown to contribute to the regulation of cell migration, whereas focal adhesion kinase (FAK) is a major player involved in both cell migration and integrin signaling. Here we show that MEKK1 and FAK are co-immunoprecipitated from mouse fibroblasts.
Toshiaki, Yujiri, Ryouhei, Nawata, Toru, Takahashi, Yutaka, Sato, Yukio, Tanizawa, Toshio, Kitamura, Yoshitomo, Oka   +6 more
openaire   +2 more sources

Focal adhesions as mechanosensors: the two-spring model [PDF]

, 2004
Adhesion-dependent cells actively sense the mechanical properties of their environment through mechanotransductory processes at focal adhesions, which are integrin-based contacts connecting the extracellular matrix to the cytoskeleton.
Schwarz, Ulrich S., Erdmann, Thorsten, Bischofs, Ilka B.   +2 more
core   +3 more sources

PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility

Cells, 2020
Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associated with poor prognosis of cancer patients.
Hsin-Wei Jen, De-Leung Gu, Yaw-Dong Lang, Yuh-Shan Jou   +3 more
doaj   +1 more source

Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells

Cell Communication and Signaling, 2020
Background Syndecans regulate cell migration thus having key roles in scarring and wound healing processes. Our previous results have shown that Thy-1/CD90 can engage both αvβ3 integrin and Syndecan-4 expressed on the surface of astrocytes to induce cell
Alejandra Valdivia, Areli Cárdenas, Marianne Brenet, Horacio Maldonado, Milene Kong, Jorge Díaz, Keith Burridge, Pascal Schneider, Alejandra San Martín, Rafael García-Mata, Andrew F. G. Quest, Lisette Leyton   +11 more
doaj   +1 more source

Interleukin 32 (IL-32) Contains a Typical α-Helix Bundle Structure That Resembles Focal Adhesion Targeting Region of Focal Adhesion Kinase-1 [PDF]

Journal of Biological Chemistry, 2012
IL-32 can be expressed in several isoforms. The amino acid sequences of the major IL-32 isoforms were used to predict the secondary and tertiary protein structure by I-TASSER software. The secondary protein structure revealed coils and α-helixes, but no β sheets.
Heinhuis, B., Koenders, M.I., Berg, W.B. van den, Netea, M.G., Dinarello, C.A., Joosten, L.A.B.   +5 more
openaire   +3 more sources

Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling

Redox Biology, 2020
Triple-negative breast cancer (TNBC) cells, which do not express genes for estrogen receptor (ER), progesterone receptor (PR), and Her2/neu, develop highly aggressive and metastatic tumors resistant to chemo- and hormonal therapies.
Eunkyung Lee, Ahyoung Choi, Yukyung Jun, Namhee Kim, Jong In Yook, Soo Youl Kim, Sanghyuk Lee, Sang Won Kang   +7 more
doaj   +1 more source

Thrombospondin-1 induces activation of focal adhesion kinase in vascular smooth muscle cells [PDF]

Journal of Vascular Surgery, 1999
Vascular smooth muscle cell (VSMC) proliferation and migration are important events in the development of intimal hyperplasia. Thrombospondin-1 (TSP-1), an extracellular matrix protein present in intimal hyperplastic lesions, has been shown to stimulate VSMC proliferation and migration.
Gahtan, Vivian, Wang, Xiu-Jie, Ikeda, Masataka, Willis, Alliric I., Tuszynski, George P., Sumpio, Bauer E.   +5 more
openaire   +2 more sources

Focal adhesion kinase confers lenvatinib resistance in hepatocellular carcinoma via the regulation of lysine‐deficient kinase 1

Molecular Carcinogenesis, 2023
AbstractLenvatinib is a clinically effective multikinase inhibitor approved for first‐line therapy of advanced hepatocellular carcinoma (HCC). Although resistance against lenvatinib often emerges and limits its antitumor activity, the underlying molecular mechanisms involved in endogenous and acquired resistance remain elusive.
Wei Hou, Shaimaa A. Gad, Xianzhong Ding, Asha Dhanarajan, Wei Qiu   +4 more
openaire   +2 more sources

Integrative Ligand-Based Pharmacophore Modeling, Virtual Screening, and Molecular Docking Simulation Approaches Identified Potential Lead Compounds against Pancreatic Cancer by Targeting FAK1

Pharmaceuticals, 2023
Pancreatic cancer is a very deadly disease with a 5-year survival rate, making it one of the leading causes of cancer-related deaths globally. Focal adhesion kinase 1 (FAK1) is a ubiquitously expressed protein in pancreatic cancer. FAK, a tyrosine kinase
Mohammad Habibur Rahman Molla, Mohammed Othman Aljahdali, Md Afsar Ahmed Sumon, Amer H. Asseri, Hisham N. Altayb, Md. Shafiqul Islam, Ahad Amer Alsaiari, F. A. Dain Md Opo, Nushrat Jahan, Foysal Ahammad, Farhan Mohammad   +10 more
doaj   +1 more source

Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Inositol hexakisphosphate kinase 1 (IP6K1) regulates numerous physiological functions. We describe a role of IP6K1 in neural development, because its deletion results in defects in neuronal migration and brain malformation. IP6K1 physiologically interacts with α-actinin and localizes to focal adhesions.
Chenglai Fu, Jing Xu, Weiwei Cheng, Tomas Rojas, Alfred C. Chin, Adele M. Snowman, Maged M. Harraz, Solomon H. Snyder   +7 more
openaire   +2 more sources