Results 11 to 20 of about 113,919,521 (303)

Role of Focal Adhesion Kinase in Regulating YB–1–Mediated Paclitaxel Resistance in Ovarian Cancer [PDF]

JNCI: Journal of the National Cancer Institute, 2013
We previously found focal adhesion kinase (FAK) inhibition sensitizes ovarian cancer to taxanes; however, the mechanisms are not well understood.We characterized the biologic response of taxane-resistant and taxane-sensitive ovarian cancer models to a novel FAK inhibitor (VS-6063).
Kang, Yu, Hu, Wei, Ivan, Cristina, Dalton, Heather J., Miyake, Takahito, Pecot, Chad V., Zand, Behrouz, Liu, Tao, Huang, Jie, Jennings, Nicholas B., Rupaimoole, Rajesha, Taylor, Morgan, Pradeep, Sunila, Wu, Sherry Y., Lu, Chunhua, Wen, Yunfei, Huang, Jianfei, Liu, Jinsong, Sood, Anil K.   +18 more
openaire   +6 more sources

Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation [PDF]

Molecular Cancer, 2005
Background Interaction with integrin and focal adhesion kinase (FAK) regulates the cancer cell adhesion and invasion into extracellular matrix (ECM). In addition, phosphorylation of FAK correlates with the increase of cell motility and invasion. Adhesion
Takeyama Hiromitsu, Takahashi Hiroki, Matsuo Yoichi, Funahashi Hitoshi, Okada Yuji, Sawai Hirozumi, Manabe Tadao   +6 more
doaj   +3 more sources

Involvement of Focal Adhesion Kinase in Inhibition of Motility of Human Breast Cancer Cells by Sphingosine 1-Phosphate

Experimental Cell Research, 1999
Sphingosine 1-phosphate (SPP), a bioactive sphingolipid metabolite, inhibits chemoinvasiveness of the aggressive, estrogen-independent MDA-MB-231 human breast cancer cell line. As in many other cell types, SPP stimulated proliferation of MDA-MB-231 cells, albeit to a lesser extent.
Wang, Fang, Nohara, Keiko, Olivera, Ana, Thompson, Erik W., Spiegel, Sarah   +4 more
openaire   +4 more sources

Crizotinib inhibits NF2-associated schwannoma through inhibition of focal adhesion kinase 1. [PDF]

Oncotarget, 2016
Neurofibromatosis type 2 (NF2) is a dominantly inherited autosomal disease characterized by schwannomas of the 8th cranial nerve. The NF2 tumor suppressor gene encodes for Merlin, a protein implicated as a suppressor of multiple cellular signaling pathways.
Troutman S, Moleirinho S, Kota S, Nettles K, Fallahi M, Johnson GL, Kissil JL.   +6 more
europepmc   +4 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation. [PDF]

Mol Oncol
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Xenou L, Tzenaki N, Tsapara A, Tzardi M, Papakonstanti EA.   +4 more
europepmc   +2 more sources

Cell Adhesion and Focal Adhesion Kinase Regulate Insulin Receptor Substrate-1 Expression [PDF]

Journal of Biological Chemistry, 2000
Integrins are transmembrane receptors involved in interactions between cells and extracellular matrix proteins. Here we show that cell adhesion regulates insulin receptor substrate-1 (IRS-1) mRNA synthesis. When fibroblasts are held in suspension, lower levels of IRS-1 mRNA, but not of IRS-2 mRNA, are detected, and this effect is due to the negative ...
Lebrun, Patricia, Baron, Véronique, Schlaepfer, David D., Obberghen, Emmanuel van, Hauck, Christof R.   +4 more
openaire   +3 more sources

MEK Kinase 1 Interacts with Focal Adhesion Kinase and Regulates Insulin Receptor Substrate-1 Expression [PDF]

Journal of Biological Chemistry, 2003
MEK kinase 1 (MEKK1) has been shown to contribute to the regulation of cell migration, whereas focal adhesion kinase (FAK) is a major player involved in both cell migration and integrin signaling. Here we show that MEKK1 and FAK are co-immunoprecipitated from mouse fibroblasts.
Toshiaki, Yujiri, Ryouhei, Nawata, Toru, Takahashi, Yutaka, Sato, Yukio, Tanizawa, Toshio, Kitamura, Yoshitomo, Oka   +6 more
openaire   +2 more sources

Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression [PDF]

Journal of Cell Biology, 2012
Vascular cell adhesion molecule–1 (VCAM-1) plays important roles in development and inflammation. Tumor necrosis factor–α (TNF-α) and focal adhesion kinase (FAK) are key regulators of inflammatory and integrin–matrix signaling, respectively. Integrin costimulatory signals modulate inflammatory gene expression, but the important control points between ...
Lim, Ssang-Taek, Miller, Nichol LG, Chen, Xiao Lei, Tancioni, Isabelle, Walsh, Colin T, Lawson, Christine, Uryu, Sean, Weis, Sara M, Cheresh, David A, Schlaepfer, David D   +9 more
openaire   +4 more sources

Interactions of the Protein-tyrosine Phosphatase-α with the Focal Adhesion Targeting Domain of Focal Adhesion Kinase Are Involved in Interleukin-1 Signaling in Fibroblasts [PDF]

Journal of Biological Chemistry, 2014
Interleukin-1 (IL-1) signaling in fibroblasts is mediated through focal adhesions, organelles that are enriched with adaptor and cytoskeletal proteins that regulate signal transduction. We examined interactions of the focal adhesion kinase (FAK) with protein-tyrosine phosphatase-α (PTP-α) in IL-1 signaling.
Qin, Wang, Yongqiang, Wang, Dominik, Fritz, Dhaarmini, Rajshankar, Gregory P, Downey, Christopher A, McCulloch   +5 more
openaire   +2 more sources

Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Inositol hexakisphosphate kinase 1 (IP6K1) regulates numerous physiological functions. We describe a role of IP6K1 in neural development, because its deletion results in defects in neuronal migration and brain malformation. IP6K1 physiologically interacts with α-actinin and localizes to focal adhesions.
Chenglai Fu, Jing Xu, Weiwei Cheng, Tomas Rojas, Alfred C. Chin, Adele M. Snowman, Maged M. Harraz, Solomon H. Snyder   +7 more
openaire   +2 more sources