Results 51 to 60 of about 1,221,131 (252)

Focal Adhesion Kinase Stabilizes the Cytoskeleton [PDF]

, 2011
Focal adhesion kinase (FAK) is a central focal adhesion protein that promotes focal adhesion turnover, but the role of FAK for cell mechanical stability is unknown.
Wolfgang H. Goldmann, Klemm, Anna H., Sandra Kienle, Kienle, Sandra, Goldmann, Wolfgang H., Ben Fabry, Tilman E. Schäffer, Anna H. Klemm, Schäffer, Tilman E, Fabry, Ben, Schäffer, Tilman E., Goldmann, Wolfgang H, Klemm, Anna H   +12 more
core   +1 more source

Diverse cell junctions with unique molecular composition in tissues of a sponge (Porifera)

EvoDevo, 2019
The integrity and organization of animal tissues depend upon specialized protein complexes that mediate adhesion between cells with each other (cadherin-based adherens junctions), and with the extracellular matrix (integrin-based focal adhesions ...
Jennyfer M. Mitchell, Scott A. Nichols
doaj   +1 more source

Molecular Docking, PASS Prediction, Pharmacokinetic and Toxicity Studies of Focal Adhesion Kinase Inhibitors

Medical Sciences Forum, 2022
Drug discovery relies on computational medicinal chemistry for designing and identifying new drug-like chemicals, predicting properties and pharmacological activities of molecules, and optimizing lead structures.
Sahaya Nadar, Tabassum Khan
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation [PDF]

, 2014
The force-dependent interaction between talin and vinculin plays a crucial role in the initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the mechano-sensitive compact N-terminal region of the talin rod, and show that
J. Yan (3377042), 陈虎, Yan, Jie, Sheetz, M.P., M. Yao (5803124), Cong, Peiwen, Yao, M, Goult, Benjamin T., Chen, H, Cong, P, Cong, P., Sheetz, Michael P., Goult, Benjamin T, M. P. Sheetz (7676465), Goult, BT, Sheetz, Michael P, Yan, J., P. Cong (7676462), Sheetz, MP, H. Chen (1500661), Yan, J, Goult, B.T., Chen, H., Yao, Mingxi, Chen, Hu, Yao, M., Benjamin T. Goult (173495)   +26 more
core   +1 more source

Differential regulation of adhesion complex turnover by ROCK1 and ROCK2. [PDF]

PLoS ONE, 2012
ROCK1 and ROCK2 are serine/threonine kinases that function downstream of the small GTP-binding protein RhoA. Rho signalling via ROCK regulates a number of cellular functions including organisation of the actin cytoskeleton, cell adhesion and cell ...
Frances E Lock, Katie R Ryan, Natalie S Poulter, Maddy Parsons, Neil A Hotchin   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Research progress of PYK2 in digestive system diseases

Frontiers in Immunology
Belonging to the focal adhesion kinase (FAK) family, proline-rich tyrosine kinase 2 (PYK2) is a non-receptor tyrosine kinase, has become a focal point in cancer research owing to its essential participation in the formation and dissemination of tumors ...
Yiyao Duan, Yiyao Duan, Mingzhu Xie, Hui Wang, Hui Wang, Sijing Chen, Sijing Chen, Jun Hu, Xujia Chen, Xujia Chen, Hong Ping Jia, Hong Ping Jia, Ningyan Zhang, Ningyan Zhang, Ling Peng, Ling Peng, Xiang Li, Hameed Ullah Khan, Hameed Ullah Khan, Die Hu, Rong Qin, Rong Qin   +21 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism [PDF]

, 2005
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous ...
S. Jayasekera, N. A. Khan, M. Stins, K. S. Kim, Alsam, S., Stins, M., Khan, Naveed Ahmed, Sissons, J., J. Sissons, Kim, K.S., Jayasekera, S., S. Alsam   +11 more
core   +1 more source