Results 31 to 40 of about 66,236 (336)

ADP-ribosylation of the rho gene product: I, Protein tyrosine phosphorylation and activation of MAP-kinase and focal adhesion kinase by lysophosphatidic acid.

Japanese Journal of Pharmacology, 1994
Kazuko Fujisawa, Narito Morii, Naokazu Kumagai, Naoki Watanabe, Shuh Narumiya   +4 more
openalex   +2 more sources

Multiple Grb2-Mediated Integrin-Stimulated Signaling Pathways to ERK2/Mitogen-Activated Protein Kinase: Summation of Both c-Src- and Focal Adhesion Kinase-Initiated Tyrosine Phosphorylation Events

Molecular and Cellular Biology, 1998
David D. Schlaepfer, Kristian Jones, Tony Hunter   +2 more
openalex   +3 more sources

Bombesin stimulates the motility of human prostate-carcinoma cells through tyrosine phosphorylation of focal adhesion kinase and of integrin-associated proteins [PDF]

International Journal of Cancer, 1997
Armen Aprikian, Lise Tremblay, Kehan Han, Simone Chevalier   +3 more
openalex   +2 more sources

Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic cancer through CD8+ T cells

Cancer Biology & Medicine, 2021
Objective: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy, due in large part to its resistance to conventional therapies, including radiotherapy (RT).
Arsen Osipov, Alex B. Blair, Juliane Liberto, Jianxin Wang, Keyu Li, Brian Herbst, Yao Xu, Shiqi Li, Nan Niu, Rufiaat Rashid, Ding Ding, Yanan Liu, Zaiqi Wang, Christopher L. Wolfgang, Richard A. Burkhart, Daniel Laheru, Lei Zheng   +16 more
doaj   +1 more source

Functional and clinical characteristics of focal adhesion kinases in cancer progression

Frontiers in Cell and Developmental Biology, 2022
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in response to stress.
Zhaoyu Zhang, Jinlong Li, Simin Jiao, G. Han, Jiaming Zhu, Tianzhou Liu   +5 more
semanticscholar   +1 more source

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

Molecular and Cellular Biology, 1995
M. B. Calalb, T. Polte, S. Hanks
semanticscholar   +3 more sources

Regulation of Fibroblast Cell Polarity by Src Tyrosine Kinase

Biomedicines, 2021
Src protein tyrosine kinases (SFKs) are a family of nonreceptor tyrosine kinases that are localized beneath the plasma membrane and are activated during cell adhesion, migration, and elongation.
Kazuo Katoh
doaj   +1 more source

PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility

Cells, 2020
Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associated with poor prognosis of cancer patients.
Hsin-Wei Jen, De-Leung Gu, Yaw-Dong Lang, Yuh-Shan Jou   +3 more
doaj   +1 more source

AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

Nature Communications, 2020
Aberrant expression of receptor tyrosine kinase AXL is linked to metastasis. AXL can be activated by its ligand GAS6 or by other kinases, but the signaling pathways conferring its metastatic activity are unknown.
A. Abu-Thuraia, Marie-Anne Goyette, J. Boulais, Carine Delliaux, Chloé Apcher, Céline Schott, Rony Chidiac, H. Bagci, M. Thibault, Dominique Davidson, Mathieu Ferron, A. Veillette, R. Daly, A. Gingras, J. Gratton, J. Côté   +15 more
semanticscholar   +1 more source

SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. [PDF]

PLoS ONE, 2014
Reactive oxygen species (ROS) regulate diverse cellular functions by triggering signal transduction events, such as Src and mitogen-activated protein (MAP) kinases.
Ara Jo, Hyunju Park, Sung-Hee Lee, So-Hee Ahn, Hee Ja Kim, Eun-Mi Park, Youn-Hee Choi   +6 more
doaj   +1 more source