Results 31 to 40 of about 25,880 (235)

Vacuolin-1 enhances RA-induced differentiation of human myeloblastic leukemia cells: evidence for involvement of a CD11b/FAK/LYN/SLP-76 axis subject to endosomal regulation that drives late differentiation steps

Cell & Bioscience, 2022
Background Retinoic acid(RA), an embryonic morphogen, regulates cell differentiation. Endocytosis regulates receptor signaling that governs such RA-directed cellular processes. Vacuolin-1 is a small molecule that disrupts endocytosis, motivating interest
Kaiyuan Zhu, Noor Kazim, Jianbo Yue, Andrew Yen   +3 more
doaj   +1 more source

Roads to Stat3 Paved with Cadherins

Cells, 2022
The engagement of cadherins, cell-to-cell adhesion proteins, triggers a dramatic increase in the levels and activity of the Rac/Cdc42 GTPases, through the inhibition of proteasomal degradation.
Hanad Adan, Juliet Daniel, Leda Raptis
doaj   +1 more source

Focal Adhesion Kinases and Calcium/Calmodulin-Dependent Protein Kinases Regulate Protein Tyrosine Phosphorylation in Stallion Sperm

Biology of Reproduction, 2013
Protein tyrosine phosphorylation (PY) is a hallmark of sperm capacitation. In stallion sperm, calcium inhibits PY at pH 7.8). These results show for the first time a role for calcium/calmodulin-dependent kinases in PRKA-dependent sperm PY; a non-PRKA-dependent pathway regulating sperm PY; and the apparent involvement of the FAK family of protein ...
Lauro, González-Fernández, Beatriz, Macías-García, Shavahn C, Loux, Dickson D, Varner, Katrin, Hinrichs   +4 more
openaire   +2 more sources

Pharmacological Inhibition of FAK-Pyk2 Pathway Protects Against Organ Damage and Prolongs the Survival of Septic Mice

Frontiers in Immunology, 2022
Sepsis and septic shock are associated with high mortality and are considered one of the major public health concerns. The onset of sepsis is known as a hyper-inflammatory state that contributes to organ failure and mortality.
Gustavo Ferreira Alves, Gustavo Ferreira Alves, Eleonora Aimaretti, Giacomo Einaudi, Raffaella Mastrocola, Junior Garcia de Oliveira, Debora Collotta, Elisa Porchietto, Manuela Aragno, Carlo Cifani, Regina Sordi, Christoph Thiemermann, Daniel Fernandes, Massimo Collino   +13 more
doaj   +1 more source

Role of Protein-tyrosine Phosphatase SHP2 in Focal Adhesion Kinase Down-regulation during Neutrophil Cathepsin G-induced Cardiomyocytes Anoikis [PDF]

Journal of Biological Chemistry, 2006
Inflammatory cells and their proteases contribute to tissue reparation at site of inflammation. Although beneficial at early stages, excessive inflammatory reaction leads to cell death and tissue damage. Cathepsin G (Cat.G), a neutrophil-derived serine protease, has been shown to induce neonatal rat cardiomyocyte detachment and apoptosis by anoikis ...
Khadija, Rafiq, Mikhail A, Kolpakov, Malika, Abdelfettah, Daniel N, Streblow, Aviv, Hassid, Louis J, Dell'Italia, Abdelkarim, Sabri   +6 more
openaire   +2 more sources

Stable association of pp60^src and pp59^fyn with the focal adhesion-associated protein tyrosine kinase, pp125^FAK [PDF]

Molecular and Cellular Biology, 1994
Changes in cellular growth and dramatic alterations in cell morphology and adhesion are common features of cells transformed by oncogenic protein tyrosine kinases, such as pp60src and other members of the Src family. In this report, we present evidence for the stable association of two Src family kinases (pp60src and pp59fyn) with tyrosine ...
B S, Cobb, M D, Schaller, T H, Leu, J T, Parsons   +3 more
openaire   +2 more sources

Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKCα Activity under Mechanical Stimulation on the Elastomeric Substrates

Cellular Physiology and Biochemistry, 2015
Background: Heparan sulfate proteoglycans (HSPGs) at the cell surface play an important role in cell adhesion, spreading, formation of focal adhesion complexes (FACs), and sensing mechanical stress.
Chun-Ping Huang, Chao-Min Cheng, Hong-Lin Su, Yi-Wen Lin   +3 more
doaj   +1 more source

Focal adhesion kinase regulates the phosphorylation protein tyrosine phosphatase-α at Tyr789 in breast cancer cells

Molecular Medicine Reports, 2015
Protein tyrosine phosphatase (PTP)‑α regulates the phosphorylation of focal adhesion kinase (FAK), which is important in cellular signal transduction and integration of proteins. It has been demonstrated that a FAK‑Del33 mutation (deletion of exon 33; KF437463) in breast cancer tissues regulates cell migration through FAK/Src signaling activation ...
Xu-Qian, Fang, Xiang-Fan, Liu, Ling, Yao, Chang-Qiang, Chen, Jia-Fei, Lin, Zhi-Dong, Gu, Pei-Hua, Ni, Xin-Min, Zheng, Qi-Shi, Fan   +8 more
openaire   +3 more sources

Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers. [PDF]

PLoS ONE, 2010
BACKGROUND: The non-receptor tyrosine kinases c-Abl and c-Src are overexpressed in various solid human tumours. Inhibition of their hyperactivity represents a molecular rationale in the combat of cancerous diseases.
Thomas Kruewel, Silvia Schenone, Marco Radi, Giovanni Maga, Astrid Rohrbeck, Maurizio Botta, Juergen Borlak   +6 more
doaj   +1 more source

Phosphorylated α-Actinin and Protein-tyrosine Phosphatase 1B Coregulate the Disassembly of the Focal Adhesion Kinase·Src Complex and Promote Cell Migration [PDF]

Journal of Biological Chemistry, 2006
The focal adhesion kinase (FAK) is a key regulator of cell migration. Phosphorylation at Tyr-397 activates FAK and creates a binding site for Src family kinases. FAK phosphorylates the cytoskeletal protein alpha-actinin at Tyr-12. Here we report that protein-tyrosine phosphatase 1B (PTP 1B) is an alpha-actinin phosphatase.
Zhiyong, Zhang, Siang-Yo, Lin, Benjamin G, Neel, Beatrice, Haimovich   +3 more
openaire   +2 more sources