Results 11 to 20 of about 25,087 (234)

PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility

Cells, 2020
Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associated with poor prognosis of cancer patients.
Hsin-Wei Jen, De-Leung Gu, Yaw-Dong Lang, Yuh-Shan Jou   +3 more
doaj   +1 more source

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. [PDF]

Proceedings of the National Academy of Sciences, 1992
A homology-based cDNA cloning approach was used to identify a widely expressed protein-tyrosine kinase designated as "focal adhesion kinase" (FadK). The entire mouse FadK amino acid sequence was deduced from cDNA clones, revealing a large (119-kDa) non-membrane-spanning protein-tyrosine kinase that lacks Src-homology SH2 and SH3 domains. Immunostaining
S K, Hanks, M B, Calalb, M C, Harper, S K, Patel   +3 more
openaire   +2 more sources

Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT [PDF]

Oncogene, 2012
Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase expressed in epithelial cancers. Disruption of Ptk6 decreases azoxymethane-induced colon tumorigenesis in mice by preventing signal transducer and activator of transcription 3 activation. Relocalization of PTK6 in prostate cancers contributes to increased growth.
Zheng, Yu, Gierut, Jessica, Wang, Zebin, Miao, Jianjun, Tyner, Angela L., Asara, John   +5 more
openaire   +4 more sources

SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. [PDF]

PLoS ONE, 2014
Reactive oxygen species (ROS) regulate diverse cellular functions by triggering signal transduction events, such as Src and mitogen-activated protein (MAP) kinases.
Ara Jo, Hyunju Park, Sung-Hee Lee, So-Hee Ahn, Hee Ja Kim, Eun-Mi Park, Youn-Hee Choi   +6 more
doaj   +1 more source

Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK. [PDF]

Molecular and Cellular Biology, 1993
Integrins play a central role in cellular adhesion and anchorage of the cytoskeleton and participate in the generation of intracellular signals, including tyrosine phosphorylation. We have recently isolated a cDNA encoding a unique, focal adhesion-associated protein tyrosine kinase (FAK) that is a component of an integrin-mediated signal transduction ...
M D, Schaller, C A, Borgman, J T, Parsons   +2 more
openaire   +2 more sources

CB1 Cannabinoid Receptors Stimulate Gβγ-GRK2-Mediated FAK Phosphorylation at Tyrosine 925 to Regulate ERK Activation Involving Neuronal Focal Adhesions

Frontiers in Cellular Neuroscience, 2020
CB1 cannabinoid receptors (CB1) are abundantly expressed in the nervous system where they regulate focal adhesion kinase (FAK) and the mitogen-activated protein kinases (MAPK) extracellular signal-regulated kinase 1 and 2 (ERK1/2).
George D. Dalton, Skyla T. Carney, Jamie D. Marshburn, Derek C. Norford, Allyn C. Howlett   +4 more
doaj   +1 more source

Angiotensin II Type I Receptor (AT1R): The Gate towards COVID-19-Associated Diseases

Molecules, 2022
The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its downregulation, which subsequently leads to the dysregulation of the renin–
George El-Arif, Shaymaa Khazaal, Antonella Farhat, Julien Harb, Cédric Annweiler, Yingliang Wu, Zhijian Cao, Hervé Kovacic, Ziad Abi Khattar, Ziad Fajloun, Jean-Marc Sabatier   +10 more
doaj   +1 more source

DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction

Journal of Biomedical Science, 2022
Background Tight junctions (TJ) are multi-protein complexes that hold epithelial cells together and form structural and functional barriers for maintaining proper biological activities.
Hsiao-Chin Chou, Chun-Mei Cheng, Chi-Hwa Yang, Tzu-Yin Lin, Ya-Wen Liu, Tse-Hua Tan, Yi-Rong Chen   +6 more
doaj   +1 more source

Evidence for In Vivo Phosphorylation of the Grb2 SH2-Domain Binding Site on Focal Adhesion Kinase by Src-Family Protein-Tyrosine Kinases [PDF]

Molecular and Cellular Biology, 1996
Focal adhesion kinase (FAK) is a nonreceptor protein-tyrosine kinase (PTK) that associates with integrin receptors and participates in extracellular matrix-mediated signal transduction events. We showed previously that the c-Src nonreceptor PTK and the Grb2 SH2/SH3 adaptor protein bound directly to FAK after fibronectin stimulation (D. D. Schlaepfer, S.
D D, Schlaepfer, T, Hunter
openaire   +2 more sources

Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner. [PDF]

PLoS ONE, 2014
Prolactin-induced Protein (PIP), an aspartyl protease unessential for normal mammalian cell function, is required for the proliferation and invasion of some breast cancer (BCa) cell types.
Sanjeev K Baniwal, Nyam-Osor Chimge, V Craig Jordan, Debu Tripathy, Baruch Frenkel   +4 more
doaj   +1 more source