Results 11 to 20 of about 25,880 (235)

Protein tyrosine phosphatase 1B targets focal adhesion kinase and paxillin in cell–matrix adhesions

Journal of Cell Science, 2021
ABSTRACT Protein tyrosine phosphatase 1B (PTP1B, also known as PTPN1) is an established regulator of cell-matrix adhesion and motility. However, the nature of substrate targets at adhesion sites remains to be validated. Here, we used bimolecular fluorescence complementation assays, in combination with a substrate trapping mutant of PTP1B,
Ana E. González Wusener, Ángela González, María E. Perez Collado, Melina R. Maza, Ignacio J. General, Carlos O. Arregui   +5 more
openaire   +2 more sources

Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily [PDF]

Journal of Biological Chemistry, 1995
A second protein-tyrosine kinase (PTK) of the focal adhesion kinase (FAK) subfamily, cell adhesion kinase beta (CAK beta), was identified by cDNA cloning. The rat CAK beta is a 115.7-kDa PTK that contains N- and C-terminal domains of 418 and 330 amino acid residues besides the central kinase domain.
H, Sasaki, K, Nagura, M, Ishino, H, Tobioka, K, Kotani, T, Sasaki   +5 more
openaire   +2 more sources

Protein-tyrosine Phosphatase PTPD1 Regulates Focal Adhesion Kinase Autophosphorylation and Cell Migration [PDF]

Journal of Biological Chemistry, 2008
PTPD1 is a cytosolic nonreceptor tyrosine phosphatase and a positive regulator of the Src-epidermal growth factor transduction pathway. We show that PTPD1 localizes along actin filaments and at adhesion plaques. PTPD1 forms a stable complex via distinct molecular modules with actin, Src tyrosine kinase, and focal adhesion kinase (FAK), a scaffold ...
Carlucci A, Gedressi C, Lignitto L, Nezi L, Villa Moruzzi E, AVVEDIMENTO, VITTORIO ENRICO, Gottesman M, GARBI, CORRADO, FELICIELLO, ANTONIO   +8 more
openaire   +4 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation. [PDF]

Mol Oncol
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Xenou L, Tzenaki N, Tsapara A, Tzardi M, Papakonstanti EA.   +4 more
europepmc   +2 more sources

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. [PDF]

Proceedings of the National Academy of Sciences, 1992
Expression of the Rous sarcoma virus-encoded oncoprotein, pp60v-src, subverts the normal regulation of cell growth, which results in oncogenic transformation. This process requires the intrinsic protein-tyrosine kinase activity of pp60v-src and is associated with an increase in tyrosine phosphorylation of a number of cellular proteins, candidate ...
M D, Schaller, C A, Borgman, B S, Cobb, R R, Vines, A B, Reynolds, J T, Parsons   +5 more
openaire   +2 more sources

Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT [PDF]

Oncogene, 2012
Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase expressed in epithelial cancers. Disruption of Ptk6 decreases azoxymethane-induced colon tumorigenesis in mice by preventing signal transducer and activator of transcription 3 activation. Relocalization of PTK6 in prostate cancers contributes to increased growth.
Zheng, Yu, Gierut, Jessica, Wang, Zebin, Miao, Jianjun, Tyner, Angela L., Asara, John   +5 more
openaire   +4 more sources

Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK. [PDF]

Molecular and Cellular Biology, 1993
Integrins play a central role in cellular adhesion and anchorage of the cytoskeleton and participate in the generation of intracellular signals, including tyrosine phosphorylation. We have recently isolated a cDNA encoding a unique, focal adhesion-associated protein tyrosine kinase (FAK) that is a component of an integrin-mediated signal transduction ...
M D, Schaller, C A, Borgman, J T, Parsons   +2 more
openaire   +2 more sources

Evidence for In Vivo Phosphorylation of the Grb2 SH2-Domain Binding Site on Focal Adhesion Kinase by Src-Family Protein-Tyrosine Kinases [PDF]

Molecular and Cellular Biology, 1996
Focal adhesion kinase (FAK) is a nonreceptor protein-tyrosine kinase (PTK) that associates with integrin receptors and participates in extracellular matrix-mediated signal transduction events. We showed previously that the c-Src nonreceptor PTK and the Grb2 SH2/SH3 adaptor protein bound directly to FAK after fibronectin stimulation (D. D. Schlaepfer, S.
D D, Schlaepfer, T, Hunter
openaire   +2 more sources

Protein tyrosine kinase 2 beta (PTK2B), but not focal adhesion kinase (FAK), is expressed in a sexually dimorphic pattern in developing mouse gonads [PDF]

Developmental Dynamics, 2010
AbstractSexual reproduction is essential for the propagation and the maintenance of fitness of our species, and is dependent on the correct development of the bipotential genital ridges into testes and ovaries. Although several transcription factors, secreted signaling molecules, and their receptors have been found to be important for testis ...
Beverdam, Annemiek, Svingen, Terje, Bagheri-Fam, Stefan, McClive, Peter, Sinclair, Andrew H., Harley, Vincent R., Koopman, Peter   +6 more
openaire   +5 more sources

Non-overlapping functions for Pyk2 and FAK in osteoblasts during fluid shear stress-induced mechanotransduction. [PDF]

PLoS ONE, 2011
Mechanotransduction, the process by which cells convert external mechanical stimuli such as fluid shear stress (FSS) into biochemical changes, plays a critical role in maintenance of the skeleton.
Suzanne R L Young, Julia M Hum, Eric Rodenberg, Charles H Turner, Fredrick M Pavalko   +4 more
doaj   +1 more source