Results 21 to 30 of about 25,880 (235)

The Non-receptor Tyrosine Kinase Pyk2 in Brain Function and Neurological and Psychiatric Diseases

Frontiers in Synaptic Neuroscience, 2021
Pyk2 is a non-receptor tyrosine kinase highly enriched in forebrain neurons. Pyk2 is closely related to focal adhesion kinase (FAK), which plays an important role in sensing cell contacts with extracellular matrix and other extracellular signals ...
Benoit de Pins, Benoit de Pins, Benoit de Pins, Tiago Mendes, Tiago Mendes, Tiago Mendes, Albert Giralt, Albert Giralt, Albert Giralt, Albert Giralt, Jean-Antoine Girault, Jean-Antoine Girault, Jean-Antoine Girault   +12 more
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Phosphorylation of p130Cas initiates Rac activation and membrane ruffling

BMC Cell Biology, 2008
Background Non-receptor tyrosine kinases (NTKs) regulate physiological processes such as cell migration, differentiation, proliferation, and survival by interacting with and phosphorylating a large number of substrates simultaneously.
Sharma Alok, Mayer Bruce J
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Oxidative stress‐induced FAK activation contributes to uterine serous carcinoma aggressiveness

Molecular Oncology, 2023
Uterine serous carcinoma (USC) is an aggressive form of endometrial cancer (EC), characterized by its high propensity for metastases. In fact, while endometrioid endometrial carcinoma (EEC), which accounts for 85% of EC, presents a good prognosis, USC is
Isabel C. Lopez‐Mejia, Jordi Pijuan, Raúl Navaridas, Maria Santacana, Sònia Gatius, Ana Velasco, Gerard Castellà, Anaïs Panosa, Elisa Cabiscol, Miquel Pinyol, Laura Coll, Núria Bonifaci, Laura Plata Peña, August Vidal, Alberto Villanueva, Eloi Gari, David Llobet‐Navàs, Lluis Fajas, Xavier Matias‐Guiu, Andrée Yeramian   +19 more
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SHP-2 Mediates Cryptosporidium parvum Infectivity in Human Intestinal Epithelial Cells. [PDF]

PLoS ONE, 2015
The parasite, Cryptosporidium parvum, induces human gastroenteritis through infection of host epithelial cells in the small intestine. During the initial stage of infection, C.
Eunice A Varughese, Susan Kasper, Emily M Anneken, Jagjit S Yadav   +3 more
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A p130^Cas tyrosine phosphorylated substrate domain decoy disrupts v-Crk signaling

BMC Cell Biology, 2002
Background The adaptor protein p130Cas (Cas) has been shown to be involved in different cellular processes including cell adhesion, migration and transformation.
Hanafusa Hidesaburo, Kensinger Margaret, Kirsch Kathrin H, August Avery   +3 more
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Mertk deficiency affects macrophage directional migration via disruption of cytoskeletal organization. [PDF]

PLoS ONE, 2015
Mertk belongs to the Tyro3, Axl and Mertk (TAM) family of receptor tyrosine kinases, and plays a pivotal role in regulation of cytoskeletal rearrangement during phagocytosis.
Yong Tang, Shen Wu, Qian Liu, Jiayi Xie, Jingxue Zhang, Dong Han, Qingxian Lu, Qingjun Lu   +7 more
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Receptor Protein-tyrosine Phosphatase α Regulates Focal Adhesion Kinase Phosphorylation and ErbB2 Oncoprotein-mediated Mammary Epithelial Cell Motility [PDF]

Journal of Biological Chemistry, 2013
We investigated the role of protein-tyrosine phosphatase α (PTPα) in regulating signaling by the ErbB2 oncoprotein in mammary epithelial cells. Using this model, we demonstrated that activation of ErbB2 led to the transient inactivation of PTPα, suggesting that attenuation of PTPα activity may contribute to enhanced ErbB2 signaling.
Boivin, Benoit, Chaudhary, Fauzia, Dickinson, Bryan C, Haque, Aftabul, Pero, Stephanie C, Chang, Christopher J, Tonks, Nicholas K   +6 more
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Protein 4.1, a component of the erythrocyte membrane skeleton and its related homologue proteins forming the protein 4.1/FERM superfamily.

Folia Histochemica et Cytobiologica, 2007
The review is focused on the domain structure and function of protein 4.1, one of the proteins belonging to the membrane skeleton. The protein 4.1 of the red blood cells (4.1R) is a multifunctional protein that localizes to the membrane skeleton and ...
Aleksander F Sikorski, Michał Grzybek, Witold Diakowski   +2 more
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Grb2 Promotes Integrin-Induced Focal Adhesion Kinase (FAK) Autophosphorylation and Directs the Phosphorylation of Protein Tyrosine Phosphatase α by the Src-FAK Kinase Complex [PDF]

Molecular and Cellular Biology, 2014
The integrin-activated Src-focal adhesion kinase (FAK) kinase complex phosphorylates PTPα at Tyr789, initiating PTPα-mediated signaling that promotes cell migration. Recruitment of the BCAR3-Cas complex by PTPα-phospho-Tyr789 at focal adhesions is one mechanism of PTPα signaling.
Cheng, Suzanne YS, Sun, Guobin, Schlaepfer, David D, Pallen, Catherine J   +3 more
openaire   +4 more sources

Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-smallcell Lung Cancer Associated With Poor Prognosis

EBioMedicine, 2018
Epidermal growth factor receptor (EGFR)-mutation-positive non-smallcell lung cancer (NSCLC) is incurable, despite high rates of response to EGFR tyrosine kinase inhibitors (TKIs).
Niki Karachaliou, Imane Chaib, Andres Felipe Cardona, Jordi Berenguer, Jillian Wilhelmina Paulina Bracht, Jie Yang, Xueting Cai, Zhigang Wang, Chunping Hu, Ana Drozdowskyj, Carles Codony Servat, Jordi Codony Servat, Masaoki Ito, Ilaria Attili, Erika Aldeguer, Ana Gimenez Capitan, July Rodriguez, Leonardo Rojas, Santiago Viteri, Miguel Angel Molina-Vila, Sai-Hong Ignatius Ou, Morihito Okada, Tony S. Mok, Trever G. Bivona, Mayumi Ono, Jean Cui, Santiago Ramón y Cajal, Peng Cao, Rafael Rosell   +28 more
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