Results 1 to 10 of about 1,278,750 (244)
Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells [PDF]
Journal of Experimental & Clinical Cancer Research, 2019 Background Focal adhesion kinase (FAK) is a cytoplasmatic protein tyrosine kinase that associates with both integrins and growth factor receptors toward the adhesion, migration and invasion of cancer cells.
Damiano Cosimo Rigiracciolo +11 more
doaj +2 more sources
Activation of Rho-kinase and focal adhesion kinase regulates the organization of stress fibers and focal adhesions in the central part of fibroblasts [PDF]
PeerJ, 2017 Specific regulation and activation of focal adhesion kinase (FAK) are thought to be important for focal adhesion formation, and activation of Rho-kinase has been suggested to play a role in determining the effects of FAK on the formation of stress fibers
Kazuo Katoh
doaj +5 more sources
Drug Discovery Targeting Focal Adhesion Kinase (FAK) as a Promising Cancer Therapy [PDF]
Molecules, 2021 Saiyang Zhang, Jian Song, Guang-Xi Yu
exaly +2 more sources
FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions
Biomolecules, 2020 Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the regulation of cell adhesion migration, proliferation and survival. In cancer FAK is a major driver of invasion and metastasis and its upregulation is associated with poor
Paula Tapial Martínez +2 more
doaj +1 more source
Cell Death and Disease, 2023 Numerous studies have investigated the various cellular responses against genotoxic stress, including those mediated by focal adhesions. We here identified a novel type of focal adhesion remodelling that occurs under genotoxic stress conditions, which ...
Masatsune Tsujioka +8 more
doaj +1 more source
Focal adhesion kinase inhibitors, a heavy punch to cancer
Discover Oncology, 2021 Kinases are the ideal druggable targets for diseases and especially were highlighted on cancer therapy. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and its aberrant signaling extensively implicates in the progression of most cancer ...
Yueling Wu +7 more
doaj +1 more source
Altering FAK-paxillin interactions reduces adhesion, migration and invasion processes. [PDF]
PLoS ONE, 2014 Focal adhesion kinase (FAK) plays an important role in signal transduction pathways initiated at sites of integrin-mediated cell adhesion to the extracellular matrix.
Thérèse B Deramaudt +6 more
doaj +1 more source
Molecules, 2020 Focal adhesion kinase (FAK) is a tyrosine kinase that is overexpressed and activated in several advanced-stage solid cancers. In cancer cells, FAK promotes the progression and metastasis of tumours.
Sahar B. Kandil +4 more
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Novel Phosphotidylinositol 4,5-Bisphosphate Binding Sites on Focal Adhesion Kinase. [PDF]
PLoS ONE, 2015 Focal adhesion kinase (FAK) is a protein tyrosine kinase that is ubiquitously expressed, recruited to focal adhesions, and engages in a variety of cellular signaling pathways.
Jun Feng, Blake Mertz
doaj +1 more source
FAK-Dependent Cell Motility and Cell Elongation
Cells, 2020 Fibroblastic cells show specific substrate selectivity for typical cell−substrate adhesion. However, focal adhesion kinase (FAK) contributes to controlling the regulation of orientation and polarity.
Kazuo Katoh
doaj +1 more source