Results 31 to 40 of about 1,278,750 (244)

Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes [PDF]

, 2007
Adhesion molecules of the integrin beta1 family are thought to be involved in the malignant progression renal cell carcinoma (RCC). Still, it is not clear how they contribute to this process.
Jones, Jon, Jüngel, Eva, Dietger Jonas, Blaheta, Roman A., Roman A.Blaheta, Stefan Berkhoff, Tobias Engl, Wedel, Steffen Alexander, Jonas, Dietger, Berkhoff, Stefan, Jon Jones, Borna Relja, Relja, Borna, Eva Weich, Steffen Wedel, Engl, Tobias A.   +15 more
core   +1 more source

PIAS1-FAK Interaction Promotes the Survival and Progression of Non-Small Cell Lung Cancer

Neoplasia: An International Journal for Oncology Research, 2016
The sequence of genomic alterations acquired by cancer cells during tumor progression and metastasis is poorly understood. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that integrates cytoskeleton remodeling, mitogenic signaling and cell
Jerfiz D. Constanzo, Ke-jing Tang, Smita Rindhe, Margherita Melegari, Hui Liu, Ximing Tang, Jaime Rodriguez-Canales, Ignacio Wistuba, Pier Paolo Scaglioni   +8 more
doaj   +1 more source

EVL is a novel focal adhesion protein involved in the regulation of cytoskeletal dynamics and vascular permeability

Pulmonary Circulation, 2021
Increases in lung vascular permeability is a cardinal feature of inflammatory disease and represents an imbalance in vascular contractile forces and barrier‐restorative forces, with both forces highly dependent upon the actin cytoskeleton.
Joseph B. Mascarenhas, Amir A. Gaber, Tania M. Larrinaga, Rachel Mayfield, Stefanie Novak, Sara M. Camp, Carol Gregorio, Jeffrey R. Jacobson, Anne E. Cress, Steven M. Dudek, Joe G.N. Garcia   +10 more
doaj   +1 more source

FAK dimerization controls its kinase‐dependent functions at focal adhesions [PDF]

The EMBO Journal, 2014
Focal adhesion kinase (FAK) controls adhesion-dependent cell motility, survival, and proliferation. FAK has kinase-dependent and kinase-independent functions, both of which play major roles in embryogenesis and tumor invasiveness. The precise mechanisms of FAK activation are not known.
Brami-Cherrier, Karen, Gervasi, Nicolas, Arsenieva, Diana, Walkiewicz, Katarzyna, Boutterin, Marie-Claude, Ortega, Alvaro, Leonard, Paul G., Seantier, Bastien, Gasmi, Laila, Bouceba, Tahar, Kadare, Gress, Girault, Jean-Antoine, Arold, Stefan T.   +12 more
openaire   +4 more sources

Recruitment of focal adhesion kinase and paxillin to β1 integrin promotes cancer cell migration via mitogen activated protein kinase activation

BMC Cancer, 2004
Background Integrin-extracellular matrix interactions activate signaling cascades such as mitogen activated protein kinases (MAPK). Integrin binding to extracellular matrix increases tyrosine phosphorylation of focal adhesion kinase (FAK).
Ohannessian Arthur, Crowe David L
doaj   +1 more source

Focal adhesion kinase plays a role in osteoblast mechanotransduction in vitro but does not affect load-induced bone formation in vivo. [PDF]

PLoS ONE, 2012
A healthy skeleton relies on bone's ability to respond to external mechanical forces. The molecular mechanisms by which bone cells sense and convert mechanical stimuli into biochemical signals, a process known as mechanotransduction, are unclear.
Alesha B Castillo, Jennifer T Blundo, Julia C Chen, Kristen L Lee, Nikitha Reddy Yereddi, Eugene Jang, Shefali Kumar, W Joyce Tang, Sarah Zarrin, Jae-Beom Kim, Christopher R Jacobs   +10 more
doaj   +1 more source

αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells [PDF]

, 2013
The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM).
Muller, Daniel J, Myllymäki, Satu M., Jens Friedrichs, Aki Manninen (221960), Matlin, Karl S., Daniel J. Muller (2509858), Manninen, Aki, Myllymäki Satu M., Manninen Aki, Jose V Moyano, Strohmeyer, Nico; id_orcid, Teräväinen, Terhi P, Muller Daniel J., Terhi P. Teräväinen (447383), Jens Friedrichs (447385), Muller, Daniel J., Satu M Myllymäki, Engler, Adam J., Friedrichs Jens, Chuanyue Wu (196653), Satu M. Myllymäki (447384), Strohmeyer, Nico, Nico Strohmeyer (447386), Karl S. Matlin (447388), Moyano, Jose V, Teräväinen, Terhi P., Terhi P Teräväinen, Karl S Matlin, Chuanyue Wu, Wu, Chuanyue, Moyano, Jose V., Strohmeyer Nico, Myllymäki, Satu M, Aki Manninen, Daniel J Muller, Jose V. Moyano (447387), Matlin Karl S., Wu Chuanyue, Moyano Jose V., Nico Strohmeyer, Matlin, Karl S, Friedrichs, Jens, Teräväinen Terhi P.   +42 more
core   +2 more sources

Focal adhesion kinase is required for actin polymerization and remodeling of the cytoskeleton during sperm capacitation

Biology Open, 2016
Several focal adhesion proteins are known to cooperate with integrins to link the extracellular matrix to the actin cytoskeleton; as a result, many intracellular signaling pathways are activated and several focal adhesion complexes are formed.
Ana L. Roa-Espitia, Eva R. Hernández-Rendón, Rafael Baltiérrez-Hoyos, Rafaela J. Muñoz-Gotera, Antonieta Cote-Vélez, Irma Jiménez, Humberto González-Márquez, Enrique O. Hernández-González   +7 more
doaj   +1 more source

Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling

Redox Biology, 2020
Triple-negative breast cancer (TNBC) cells, which do not express genes for estrogen receptor (ER), progesterone receptor (PR), and Her2/neu, develop highly aggressive and metastatic tumors resistant to chemo- and hormonal therapies.
Eunkyung Lee, Ahyoung Choi, Yukyung Jun, Namhee Kim, Jong In Yook, Soo Youl Kim, Sanghyuk Lee, Sang Won Kang   +7 more
doaj   +1 more source

RIOK3 promotes pancreatic ductal adenocarcinoma cell invasion and metastasis by stabilizing FAK

Heliyon, 2022
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive cancer, characterized by a high metastatic burden. RIO Kinase 3 (RIOK3) has been shown to promote invasion and metastasis of PDAC by cytoskeleton remodeling, but the exact mechanism is ...
Mengyuan Xu, Lei Fang, Xin Guo, Henan Qin, Rui Sun, Zhen Ning, Aman Wang   +6 more
doaj   +1 more source