Results 51 to 60 of about 1,278,750 (244)

FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs

Scientific Reports, 2021
Focal adhesion kinase (FAK) localizes to focal adhesions and is overexpressed in many cancers. FAK can also translocate to the nucleus, where it binds to, and regulates, several transcription factors, including MBD2, p53 and IL-33, to control gene ...
Billie G. C. Griffith, Rosanna Upstill-Goddard, Holly Brunton, Graeme R. Grimes, Andrew V. Biankin, Bryan Serrels, Adam Byron, Margaret C. Frame   +7 more
doaj   +1 more source

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration [PDF]

Journal of Cell Science, 1999
ABSTRACT FAK localizes to sites of transmembrane integrin receptor clustering and facilitates intracellular signaling events. FAK-null (FAK−) fibroblasts exhibit a rounded morphology, defects in cell migration, and an elevated number of cell-substratum contact sites.
Sieg, David J., Schlaepfer, David D., Hauck, Christof R.   +2 more
openaire   +3 more sources

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

The Atypical Kinesin KIF26A Facilitates Termination of Nociceptive Responses by Sequestering Focal Adhesion Kinase

Cell Reports, 2018
Summary: Kinesin superfamily proteins (KIFs) are molecular motors that typically alter the subcellular localization of their cargos. However, the atypical kinesin KIF26A does not serve as a motor but can bind microtubules and affect cellular signaling ...
Li Wang, Yosuke Tanaka, Doudou Wang, Momo Morikawa, Ruyun Zhou, Noriko Homma, Yuki Miyamoto, Nobutaka Hirokawa   +7 more
doaj   +1 more source

Cortactin as a target for FAK in the regulation of focal adhesion dynamics. [PDF]

PLoS ONE, 2012
Efficient cell movement requires the dynamic regulation of focal adhesion (FA) formation and turnover. FAs are integrin-associated sites of cell attachment and establish linkages to the cellular actin cytoskeleton.
Alok Tomar, Christine Lawson, Majid Ghassemian, David D Schlaepfer   +3 more
doaj   +1 more source

Oncogenic Receptor Tyrosine Kinases Directly Phosphorylate Focal Adhesion Kinase (FAK) as a Resistance Mechanism to FAK-Kinase Inhibitors [PDF]

Molecular Cancer Therapeutics, 2016
Abstract Focal adhesion kinase (FAK) is a major drug target in cancer and current inhibitors targeted to the ATP-binding pocket of the kinase domain have entered clinical trials. However, preliminary results have shown limited single-agent efficacy in patients.
Timothy A, Marlowe, Felicia L, Lenzo, Sheila A, Figel, Abigail T, Grapes, William G, Cance   +4 more
openaire   +2 more sources

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

Focal Adhesion Targeting: The Critical Determinant of FAK Regulation and Substrate Phosphorylation [PDF]

, 1999
The focal adhesion kinase (FAK) is discretely localized to focal adhesions via its C-terminal focal adhesion–targeting (FAT) sequence. FAK is regulated by integrin-dependent cell adhesion and can regulate tyrosine phosphorylation of downstream substrates,
Schaller, Michael D., Shen, Yu
core   +1 more source

Structure-based discovery of hydrocarbon-stapled paxillin peptides that block FAK scaffolding in cancer

Nature Communications
The focal adhesion kinase (FAK) scaffold provides FAK-targeted cancer therapeutics with greater efficacy and specificity than traditional kinase inhibitors. The FAK scaffold function largely involves the interaction between FAK’s focal adhesion targeting
Lauren Reyes, Lena Naser, Warren S. Weiner, Darren Thifault, Erik Stahl, Liam McCreary, Rohini Nott, Colton Quick, Alex Buchberger, Carlos Alvarado, Andrew Rivera, Joseph A. Miller, Ruchi Khatiwala, Brian R. Cherry, Ronald Nelson, Jose M. Martin-Garcia, Nicholas Stephanopoulos, Raimund Fromme, Petra Fromme, William Cance, Timothy Marlowe   +20 more
doaj   +1 more source

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

Advanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang, Narina Jung, Min‐Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park   +6 more
wiley   +1 more source