Results 41 to 50 of about 1,278,750 (244)

Degradation and Dephosphorylation of Focal Adhesion Kinase During Okadaic Acid-Induced Apoptosis in Human Neuroblastoma Cells

Neoplasia: An International Journal for Oncology Research, 2003
Focal adhesion kinase (FAK) prevents apoptosis in many cell types. We have reported that tyrosine residues in FAK are dephosphorylated and FAK is degraded during mannitol-induced apoptosis in human neuroblastoma cells.
Bhumsoo Kim, Cynthia M. van Golen, Eva L. Feldman   +2 more
doaj   +1 more source

FAK PROTAC Inhibits Ovarian Tumor Growth and Metastasis by Disrupting Kinase Dependent and Independent Pathways

Frontiers in Oncology, 2022
Focal adhesion kinase (FAK) is highly expressed in a variety of human cancers and is a target for cancer therapy. Since FAK kinase inhibitors only block the kinase activity of FAK, they are not highly effective in clinical trials. FAK also functions as a
Xueyun Huo, Xueyun Huo, Xueyun Huo, Wenjing Zhang, Guannan Zhao, Guannan Zhao, Zhenwen Chen, Peixin Dong, Hidemichi Watari, Ramesh Narayanan, Ramesh Narayanan, Todd D. Tillmanns, Lawrence M. Pfeffer, Lawrence M. Pfeffer, Junming Yue, Junming Yue   +15 more
doaj   +1 more source

A FAK conundrum is solved: activation and organization of focal adhesion kinase at the plasma membrane [PDF]

, 2020
Focal adhesion kinase (FAK) is a central mediator of cell adhesion, acting both as a scaffold and as catalytically active kinase. Acebronet al(2020) use cryo-electron microscopy (cryo-EM) to visualize the dramatic structural changes that occur ...
Brod, F., Fässler, R., Florian Brod, Reinhard Fässler   +3 more
core   +1 more source

Signal Transduction Mechanisms of Focal Adhesions: Src and FAK-Mediated Cell Response

Frontiers in Bioscience-Landmark
Cell-to-substrate adhesion sites, also known as focal adhesion sites (FAs), are complexes of different proteins on the cell surface. FAs play important roles in communication between cells and the extracellular matrix (ECM), leading to signal ...
Kazuo Katoh
doaj   +1 more source

Caffeine Inhibits Migration in Glioma Cells through the ROCK-FAK Pathway

Cellular Physiology and Biochemistry, 2014
Aims: Glioma is the most malignant brain tumor that has the ability to migrate and invade the CNS. In this study, we investigated the signaling mechanism of caffeine on the migration of glioma cells.
Ying Chen, Wei-Chung Chou, You-Ming Ding, Ya-Chieh Wu   +3 more
doaj   +1 more source

Paxillin Binding Is Not the Sole Determinant of Focal Adhesion Localization or Dominant-Negative Activity of Focal Adhesion Kinase/Focal Adhesion Kinase-related Nonkinase [PDF]

, 2000
The carboxy-terminal 150 residues of the focal adhesion kinase (FAK) comprise the focal adhesion-targeting sequence, which is responsible for its subcellular localization. The mechanism of focal adhesion targeting has not been fully elucidated.
Schaller, M. D., Broome, J. M., Ohngemach, C., Romer, L. H., Cooley, M. A.   +4 more
core   +1 more source

Mechanotransduction in striated muscle via focal adhesion kinase [PDF]

, 2007
Contractile tissues demonstrate a pronounced capacity to remodel their composition in response to mechanical challenges. Descriptive evidence suggests the upstream involvement of the phosphotransfer enzyme FAK (focal adhesion kinase) in the molecular ...
M Flück, Desplanches, D, Durieux, AC, Flück, M, Flueck, M., D Freyssenet, Freyssenet, D., Freyssenet, D, A C Durieux, Durieux, A. C., D Desplanches, Freyssenet, O, Durieux, A C, Desplanches, D., Flück M, Desplanches D, Durieux, A.C., Flück, M., Freyssenet D, Durieux AC   +19 more
core   +1 more source

Focal adhesion kinase as a new player in the biology of onco-hematological diseases: the starting evidence

Frontiers in Oncology
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase mainly found in the focal adhesion regions of the plasma membrane and it has a crucial role in migration and the remodeling of cellular morphology.
Guido Capasso, Nayla Mouawad, Maria Castronuovo, Edoardo Ruggeri, Andrea Visentin, Livio Trentin, Federica Frezzato   +6 more
doaj   +1 more source

Focal adhesion kinase inhibitor BI 853520 inhibits cell proliferation, migration and EMT process through PI3K/AKT/mTOR signaling pathway in ovarian cancer

Discover Oncology, 2021
Focal adhesion kinase (FAK) activation has been reported to be associated with cell progression and metastasis in a wide variety of cancer cells. Target treatment by inhibiting FAK has achieved remarkable effects in several cancers, but the effect in ...
Hong Li, Yizhi Gao, Chenchen Ren
doaj   +1 more source

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source