Results 21 to 30 of about 1,278,750 (244)

Recent advances in focal adhesion kinase (FAK)-targeting antitumor agents. [PDF]

RSC Adv
The recent avances in the design and biological activity of FAK-targeting antitumor agents are summarized in this review with a focus on their chemical structures, antitumor effects, and clinical progress.
Zhu SK, Wu Q, Liu GX, Geng AQ, Wang PA.
europepmc   +3 more sources

Focal adhesion kinase (FAK): A regulator of CNS myelination [PDF]

Journal of Neuroscience Research, 2009
AbstractThe formation of the myelin sheath is a crucial step during development because it enables fast and efficient propagation of signals within the limited space of the mammalian central nervous system (CNS). During the process of myelination, oligodendrocytes actively interact with the extracellular matrix (ECM).
Audrey D, Forrest, Hilary E, Beggs, Louis F, Reichardt, Jeffrey L, Dupree, Raymond J, Colello, Babette, Fuss   +5 more
openaire   +2 more sources

FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells [PDF]

, 2011
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that is elevated in a variety of human cancers. While FAK is implicated in many cellular processes that are perturbed in cancer, including proliferation, actin and adhesion dynamics ...
Moran-Jones Kim, Moran-Jones, K., Graham Kathryn, Brunton Valerie G., Margaret C Frame, Owen J. Sansom, Frame, Margaret C., Moran-jones, Kim, Frame, M.C., Sansom, Owen J., Owen J Sansom, Brunton, V.G., Valerie G Brunton, Frame Margaret C., Valerie G. Brunton, Margaret C. Frame, Graham, K., Brunton, Valerie G., Kathryn Graham, Graham, Kathryn, Sansom Owen J., Sansom, O.J., Kim Moran-Jones   +22 more
core   +1 more source

Epidermal Growth Factor Receptor substrate 8 (Eps8) controls Src/FAK-dependent phenotypes in squamous carcinoma cells [PDF]

, 2014
Eps8 is an actin regulatory scaffold protein increased in Squamous Cell Carcinoma (SCC) cells. It forms a complex with both Focal Adhesion Kinase (FAK) and c-Src in SCC cells derived from the DMBA/TPA model of skin carcinogenesis.
Schoenherr, Christina, Baillie, George S., Frame, Margaret, Heath, John K., Proby, Charlotte, Frame, Margaret C., Findlay, Jane E, Cunningham, Debbie L., Findlay, Jane E., Baillie, George S, Heath, John K, Serrels, Bryan, Frame, Margaret C, Cunningham, Debbie L; id_orcid   +13 more
core   +1 more source

Discovery of Focal Adhesion Kinase (FAK) activators to promote intestinal mucosal healing. [PDF]

Eur J Med Chem
Chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) causes injuries in the gastrointestinal mucosa. Proton pump inhibitors are the most common drugs prescribed to decrease upper gastrointestinal side effects caused by NSAIDs. However, they worsen the lower GI injuries caused by NSAIDs and do not directly promote restitution of the epithelial ...
Gallardo-Macias R, Wang Q, Raafat Elsayed AA, Liu G, Wong HL, Georg GI, Basson MD, Gurvich VJ.   +7 more
europepmc   +3 more sources

Costamere remodeling with muscle loading and unloading in healthy young men [PDF]

, 2013
Costameres are mechano-sensory sites of focal adhesion in the sarcolemma that provide a structural anchor for myofibrils. Their turnover is regulated by integrin-associated focal adhesion kinase (FAK).
Erskine, Robert M., Seynnes, Olivier R., Simunic, B, Narici, MV, Flück M., Pisot, R, Flück, M., Rittweger J., Rittweger, Joern, Flueck, M, Narici M. V., Narici, Marco, Narici, Marco V., Flück, Martin, Seynnes O. R., Erskine, Robert, Li R., Rittweger, Jörn, Rittweger, J, Pisot, Rado, Seynnes, Olivier R, Seynnes, OR, Pišot R., Seynnes, Olivier, Li, Ruowei, Erskine, Robert M, Narici, Marco V, Erskine, RM, Šimunič B., Narici, Marco Vincenzo, Simunic, Bostjan, Erskine R. M., Li, R   +32 more
core   +1 more source

TGFβ-induced EMT requires focal adhesion kinase (FAK) signaling [PDF]

Experimental Cell Research, 2008
The epithelial-to-mesenchymal transition (EMT) is a crucial process, occurring both during development and tumor progression, by which an epithelial cell undergoes a conversion to a mesenchymal phenotype, dissociates from initial contacts and migrates to secondary sites.
CICCHINI, Carla, LAUDADIO I, CITARELLA, Franca, CORAZZARI M, STEINDLER C, CONIGLIARO A, FANTONI A, AMICONE, Laura, TRIPODI, Marco   +8 more
openaire   +5 more sources

FAK family kinases: The Yin and Yang of cancer cell invasiveness

Molecular & Cellular Oncology, 2018
Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular ...
Alessandro Genna, Hava Gil-Henn
doaj   +1 more source

Functional and clinical characteristics of focal adhesion kinases in cancer progression

Frontiers in Cell and Developmental Biology, 2022
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in response to stress.
Zhaoyu Zhang, Jinlong Li, Simin Jiao, Guangda Han, Jiaming Zhu, Tianzhou Liu   +5 more
doaj   +1 more source

MYCN neuroblastoma and focal adhesion kinase FAK [PDF]

Frontiers in Bioscience, 2011
Neuroblastoma is the most common extracranial solid tumor of childhood. This tumor is characterized by poor survival, especially when it features amplification of the MYCN oncogene. The ability for human cancers to propagate is marked by their ability to invade and metastasize to distant sites.
openaire   +2 more sources