Results 11 to 20 of about 1,278,750 (244)

Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. [PDF]

Molecular Biology of the Cell, 1996
It has been proposed that the focal adhesion kinase (FAK) mediates focal adhesion formation through tyrosine phosphorylation during cell adhesion. We investigated the role of FAK in focal adhesion structure and function. Loading cells with a glutathione-S-transferase fusion protein (GST-Cterm) containing the FAK focal adhesion targeting sequence, but ...
A P, Gilmore, L H, Romer
openaire   +4 more sources

Mechanism of Focal Adhesion Kinase Mechanosensing.

PLoS Computational Biology, 2015
Mechanosensing at focal adhesions regulates vital cellular processes. Here, we present results from molecular dynamics (MD) and mechano-biochemical network simulations that suggest a direct role of Focal Adhesion Kinase (FAK) as a mechano-sensor. Tensile
Jing Zhou, Camilo Aponte-Santamaría, Sebastian Sturm, Jakob Tómas Bullerjahn, Agnieszka Bronowska, Frauke Gräter   +5 more
doaj   +2 more sources

Focal adhesion kinase(FAK), une protéine aux fonctions multiples [PDF]

médecine/sciences, 2003
Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase localized to regions called focal adhesions. Many stimuli can induce tyrosine phosphorylation and activation of FAK, including integrins and growth factors. The major site of autophosphorylation, tyrosine 397, is a docking site for the SH2 domains of Src family proteins.
Cornillon, Jérôme, Campos, Lydia, Guyotat, Denis   +2 more
openaire   +4 more sources

Focal adhesion kinase (FAK) expression in normal and neoplastic lymphoid tissues

Pathology - Research and Practice, 2009
Focal adhesion kinase (FAK) is a protein tyrosine kinase essential for intracellular regulatory events, such as cell growth, differentiation, migration and tumor metastasis. The aim of this study was to analyze the expression of FAK protein in a series of normal and neoplastic lymphoid tissues.
Mason, David Y., ÖZKAL, SERMİN, Marafioti, Teresa, Manek, Sanjiv, Kargi, Aydanur, Hansmann, Martin-Leo, Tedoldi, Sara, Paterson, Jennifer C.   +7 more
openaire   +4 more sources

O-GlcNAcylation of Focal Adhesion Kinase Regulates Cell Adhesion, Migration, and Proliferation via the FAK/AKT Pathway

Biomolecules
Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase pivotal in cellular signal transduction, regulating cell adhesion, migration, growth, and survival. However, the regulatory mechanisms of FAK during tumorigenesis and progression still need to
Zhiwei Zhang, Tomoya Isaji, Yoshiyuki Oyama, Jianwei Liu, Zhiwei Xu, Yuhan Sun, Tomohiko Fukuda, Haojie Lu, Jianguo Gu   +8 more
doaj   +2 more sources

Discovery of a Pyrimidothiazolodiazepinone as a Potent and Selective Focal Adhesion Kinase (FAK) Inhibitor. [PDF]

ACS Med Chem Lett, 2021
Focal adhesion kinase (FAK) is a tyrosine kinase with prominent roles in protein scaffolding, migration, angiogenesis, and anchorage-independent cell survival and is an attractive target for the development of cancer therapeutics. However, current FAK inhibitors display dual kinase inhibition and/or significant activity on several kinases.
Groendyke BJ, Nabet B, Mohardt ML, Zhang H, Peng K, Koide E, Coffey CR, Che J, Scott DA, Bass AJ, Gray NS.   +10 more
europepmc   +4 more sources

Modelling stromal FAK regulation of tumour growth, angiogenesis and progression [PDF]

, 2012
PhDThe growth of tumours within a whole organism depends on the tumour microenvironment. This involves both resident stromal cells, such as endothelial cells and fibroblasts, and also bone marrow derived stromal cells.
Batista, Silvia
core   +4 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation. [PDF]

Mol Oncol
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Xenou L, Tzenaki N, Tsapara A, Tzardi M, Papakonstanti EA.   +4 more
europepmc   +2 more sources

Proteome Analysis of Focal Adhesion Kinase (FAK)-Overexpressing Cells [PDF]

Biological and Pharmaceutical Bulletin, 2004
We established several focal adhesion kinase (FAK) cDNA-transfected cells and found that FAK-transfected HL-60 (HL-60/FAK) cells are resistant to apoptosis induced with hydrogen peroxide, etoposide and radiation compared with the parental HL-60 or the vector-transfected (HL-60/Vect) cells.
Utsubo, Ryoko, Sonoda, Yoshiko, Takahashi, Reiko, Iijima, Shiro, Aizu-Yokota, Eriko, Kasahara, Tadashi   +5 more
  +7 more sources

The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review. [PDF]

J Exp Clin Cancer Res, 2019
FAK is a tyrosine kinase overexpressed in cancer cells and plays an important role in the progression of tumors to a malignant phenotype. Except for its typical role as a cytoplasmic kinase downstream of integrin and growth factor receptor signaling, related studies have shown new aspects of the roles of FAK in the nucleus.
Zhou J, Yi Q, Tang L.
europepmc   +5 more sources