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Integrins in cancer: insights into mechanisms and therapeutic potential [PDF]
Cell Communication and SignalingIntegrins are transmembrane glycoproteins that act as essential adhesion receptors, allowing cells to communicate with the extracellular matrix (ECM).
Parth Agarwal +4 more
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αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
Nature Communications, 2017 Interaction of fibronectin with αv-class and α5β1 integrins results in formation of cell adhesion complexes, but the initial events (
Mitasha Bharadwaj +2 more
exaly +2 more sources
Integrins mediate symbiont-specific uptake in cnidarian larvae [PDF]
EMBO ReportsEndosymbiosis between dinoflagellate algae and cnidaria is fundamental for coral reef health. Appropriate symbiont selection is required for sufficient host nutrient acquisition and could be tailored to increase cnidarian stress tolerance.
Victor A S Jones +10 more
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Integrins and Integrin-Associated Proteins in the Cardiac Myocyte [PDF]
Circulation Research, 2014 Integrins are heterodimeric, transmembrane receptors that are expressed in all cells, including those in the heart. They participate in multiple critical cellular processes including adhesion, extracellular matrix organization, signaling, survival, and proliferation. Particularly relevant for a contracting muscle cell, integrins are mechanotransducers,
Ana Maria Manso +2 more
exaly +5 more sources
Above the Matrix: Functional Roles for Apically Localized Integrins
Frontiers in Cell and Developmental Biology, 2021 Integrins are transmembrane proteins that are most typically thought of as integrating adhesion to the extracellular matrix with intracellular signaling and cell regulation.
Raven J. Peterson +2 more
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Integrins in human hepatocellular carcinoma tumorigenesis and therapy
Chinese Medical Journal, 2023 . Integrins are a family of transmembrane receptors that connect the extracellular matrix and actin skeleton, which mediate cell adhesion, migration, signal transduction, and gene transcription.
Qiong Gao +3 more
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Cell and Tissue Research, 2009 Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. The integrin family is composed of 24 alphabeta heterodimeric members that mediate the attachment of cells to the extracellular matrix (ECM) but that also take part in specialized cell-cell interactions.
Barczyk, Malgorzata +2 more
openaire +2 more sources
Molecular Therapy: Oncolytics, 2022 High-grade gliomas (HGGs) are lethal central nervous system tumors that spread quickly through the brain, making treatment challenging. Integrins are transmembrane receptors that mediate cell-extracellular matrix (ECM) interactions, cellular adhesion ...
Kimberly Ann Rivera-Caraballo +4 more
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Genome Biology, 2007 The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane alphabeta heterodimers and at least 18 alpha and eight beta subunits are known in humans, generating 24 heterodimers.
Takada, Yoshikazu +2 more
openaire +4 more sources
Integrins in the Immunity of Insects: A Review
Frontiers in Immunology, 2022 Integrins are a large group of cell-surface proteins that are classified as transmembrane proteins. Integrins are classified into different types based on sequence variations, leading to structural and functional diversity.
Saima Kausar +8 more
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