Results 1 to 10 of about 102,019 (265)

Lipid-rafts remain stable even after ionizing radiation induced disintegration of β1 integrin containing focal adhesions

BMC Research Notes, 2017
Objective Adhesion of cells to the extracellular matrix is facilitated by integrin receptors. We recently found that a nanoscale organization of plasma membrane located integrins containing the β1 subunit is responsible for an enhanced radio-resistance ...
Laura Babel, Larissa Kruse, Steven Bump, Markus Langhans, Tobias Meckel   +4 more
doaj   +1 more source

Biology and structure of leukocyte β2 integrins and their role in inflammation [version 1; referees: 3 approved]

F1000Research, 2016
Integrins comprise a large family of αβ heterodimeric cell adhesion receptors that are expressed on all cells except red blood cells and that play essential roles in the regulation of cell growth and function.
M. Amin Arnaout
doaj   +1 more source

Integrins are required for synchronous ommatidial rotation in the Drosophila eye linking planar cell polarity signalling to the extracellular matrix [PDF]

Open Biology, 2019
Integrins mediate the anchorage between cells and their environment, the extracellular matrix (ECM), and form transmembrane links between the ECM and the cytoskeleton, a conserved feature throughout development and morphogenesis of epithelial organs ...
Maria Thuveson, Konstantin Gaengel, Giovanna M. Collu, Mei-ling Chin, Jaskirat Singh, Marek Mlodzik   +5 more
doaj   +1 more source

Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis

Molecular Cancer, 2011
Background Although integrins have been implicated in the progression of breast cancer, the exact mechanism whereby they exert this regulation is clearly not understood.
Hazari Siddhartha, Bao Lili, Jain Prachi, Rathinam Rajamani, Baranwal Somesh, Shenouda Sylvia, Wang Yanfang, Dash Srikanta, Alahari Suresh K   +8 more
doaj   +1 more source

Integrin activation is an essential component of SARS-CoV-2 infection

Scientific Reports, 2021
SARS-CoV-2 infection depends on binding its spike (S) protein to angiotensin-converting enzyme 2 (ACE2). The S protein expresses an RGD motif, suggesting that integrins may be co-receptors. Here, we UV-inactivated SARS-CoV-2 and fluorescently labeled the
Peter Simons, Derek A. Rinaldi, Virginie Bondu, Alison M. Kell, Steven Bradfute, Diane S. Lidke, Tione Buranda   +6 more
doaj   +1 more source

β1 integrins mediate the BMP2 dependent transcriptional control of osteoblast differentiation and osteogenesis. [PDF]

PLoS ONE, 2018
Osteoblast differentiation is a highly regulated process that requires coordinated information from both soluble factors and the extracellular matrix. Among these extracellular stimuli, chemical and physical properties of the matrix are sensed through ...
Molly Brunner, Noémie Mandier, Thierry Gautier, Genevieve Chevalier, Anne-Sophie Ribba, Philippe Guardiola, Marc R Block, Daniel Bouvard   +7 more
doaj   +1 more source

The primacy of β1 integrin activation in the metastatic cascade. [PDF]

PLoS ONE, 2012
After neoplastic cells leave the primary tumor and circulate, they may extravasate from the vasculature and colonize tissues to form metastases. β1 integrins play diverse roles in tumorigenesis and tumor progression, including extravasation.
Hisashi Kato, Zhongji Liao, John V Mitsios, Huan-You Wang, Elena I Deryugina, Judith A Varner, James P Quigley, Sanford J Shattil   +7 more
doaj   +1 more source

β1 Integrin Cell-surface Immunoprecipitation (Selective Immunoprecipitation)

Bio-Protocol, 2013
Immunoprecipitation (IP) is a widely used method to isolate a specific protein from a mixed protein sample using an antibody that exclusively binds to that particular protein.
Ralph Boettcher
doaj   +1 more source

Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits

mAbs
Integrins are cell surface receptors that mediate the interactions of cells with their surroundings and play essential roles in cell adhesion, migration, and homeostasis.
Yuxin Hao, Jiabin Yan, Courtney Fraser, Aiping Jiang, Murali Anuganti, Roushu Zhang, Kenneth Lloyd, Joseph Jardine, Jessica Coppola, Rob Meijers, Jing Li, Timothy A. Springer   +11 more
doaj   +1 more source

β2 Integrins As Regulators of Dendritic Cell, Monocyte, and Macrophage Function

Frontiers in Immunology, 2017
Emerging evidence suggests that the β2 integrin family of adhesion molecules have an important role in suppressing immune activation and inflammation.
Leonie Schittenhelm, Leonie Schittenhelm, Leonie Schittenhelm, Catharien M. Hilkens, Catharien M. Hilkens, Vicky L. Morrison, Vicky L. Morrison   +6 more
doaj   +1 more source