Results 1 to 10 of about 202,411 (268)
Myosin-X and talin modulate integrin activity at filopodia tips
Cell Reports, 2021 Summary: Filopodia assemble unique integrin-adhesion complexes to sense the extracellular matrix. However, the mechanisms of integrin regulation in filopodia are poorly defined.
Mitro Miihkinen +7 more
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N-glycosylation of ß4 integrin controls the adhesion and motility of keratinocytes. [PDF]
PLoS ONE, 2011 α6ß4 integrin is an essential component of hemidesmosomes and modulates cell migration in wound healing and cancer invasion. To elucidate the role of N-glycosylation on ß4 integrin, we investigated keratinocyte adhesion and migration through the re ...
Yoshinobu Kariya, Jianguo Gu
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Lung injury, a severe adverse outcome of lipopolysaccharide‐induced acute respiratory distress syndrome, is attributed to excessive neutrophil recruitment and effector response.
Ziwei Ou +9 more
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Calreticulin Regulates β1-Integrin mRNA Stability in PC-3 Prostate Cancer Cells
Biomedicines, 2022 Prostate cancer (PCa) is the major cause of cancer-related death among aging men worldwide. Recent studies have suggested that calreticulin (CRT), a multifunctional chaperon protein, may play an important role in the regulation of PCa tumorigenesis and ...
Yueh-Chien Lin +6 more
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Deiodinase-3 is a thyrostat to regulate podocyte homeostasis
EBioMedicine, 2021 : Background: Nephrotic syndrome (NS) is associated with kidney podocyte injury and may occur as part of thyroid autoimmunity such as Graves’ disease.
Shivangi Agarwal +13 more
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Frontiers in Pharmacology, 2021 The ongoing COVID-19 pandemic has raised concerns about the risk of SARS-CoV-2 infection in patients with Crohn’s disease (CD) and patients with ulcerative colitis (UC) taking immunosuppressants or biologics.
Irene Marafini +3 more
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Targeting of the COX-2/PGE2 axis enhances the antitumor activity of T7 peptide in vitro and in vivo
Drug Delivery, 2021 T7 peptide is considered as an antiangiogenic polypeptide. The presents study aimed to further detect the antiangiogenic mechanisms of T7 peptide and determine whether combining T7 peptide and meloxicam (COX-2/PGE2 specific inhibitor) could offer a ...
Jianrong Yang +13 more
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Frontiers in Cell and Developmental Biology, 2020 Angiogenesis is defined as the formation of new capillaries by sprouting from the pre-existing microvasculature. It occurs in physiological and pathological processes particularly in tumor growth and metastasis.
Alexia Vautrin-Glabik +28 more
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Pathophysiological roles of integrins in gliomas from the perspective of glioma stem cells
Frontiers in Cell and Developmental Biology, 2022 Glioblastoma is the most common primary intracranial tumor and is also one of the most malignant central nervous system tumors. Its characteristics, such as high malignancy, abundant tumor vasculature, drug resistance, and recurrence-prone nature, cause ...
Maoyu Wang +3 more
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Molecular Oncology, 2023 While organ‐confined prostate cancer (PCa) is mostly therapeutically manageable, metastatic progression of PCa remains an unmet clinical challenge.
Anna Aakula +18 more
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