Results 1 to 10 of about 272,677 (316)

Periostin-integrin signaling in hepatocellular carcinoma: from biological function to clinical application

Frontiers in Cell and Developmental Biology
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide and the most common primary tumor. Periostin (POSTN) is located in the extracellular matrix (ECM) and triggers tumor growth signals by binding to integrin receptors.
Jun Lei, Yong Liu, Shuai Yuan, Xiaxia Yuan, Qi Yuan   +4 more
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Hydrogels Derivatized With Cationic Moieties or Functional Peptides as Efficient Supports for Neural Stem Cells

Frontiers in Neuroscience, 2020
The increasing incidence of neurodegenerative diseases such as Alzheimer’s or Parkinson’s disease represents a significant burden for patients and national health systems.
Kristin Glotzbach, Nils Stamm, Ralf Weberskirch, Andreas Faissner   +3 more
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Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6

Advanced Science
Inside‐out and outside‐in activations of integrin both play important roles in adhesion formation and cell motility. While such mechanisms of RGD‐binding integrin, including integrin β1 and β3, are well documented, mechanosensitive regulations of ...
Wan Ning Lee, Jiamin Li, Nan‐Peng Chen, Cheng‐han Yu   +3 more
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Experimental Right Ventricular Hypertension Induces Regional β1‐Integrin–Mediated Transduction of Hypertrophic and Profibrotic Right and Left Ventricular Signaling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundDevelopment of right ventricular (RV) hypertension eventually contributes to RV and left ventricular (LV) myocardial fibrosis and dysfunction. The molecular mechanisms are not fully elucidated.
Mei Sun, Ryo Ishii, Kenichi Okumura, Adrienn Krauszman, Siegfried Breitling, Olga Gomez, Aleksander Hinek, Stellar Boo, Boris Hinz, Kim A. Connelly, Wolfgang M. Kuebler, Mark K. Friedberg   +11 more
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Evaluation of Integrin Glycovariants as Biomarkers of Metastasis, Invasion, and Therapy Stratification in Head and Neck Squamous Cell Carcinoma

Cancer Medicine
Background Integrin glycosylation is one mechanism regulating the invasion and metastasis of malignant tumors. Little information exists about integrin glycosylation in head and neck squamous cell carcinoma (HNSCC).
Erica Routila, Sadie Salminen, Randa Mahran, Mervi Toriseva, Heikki Irjala, Eeva Haapio, Eero Kytö, Sami Ventelä, Kim Pettersson, Johannes Routila, Kamlesh Gidwani, Janne Leivo   +11 more
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N-Formyl Peptide Receptors Induce Radical Oxygen Production in Fibroblasts Derived From Systemic Sclerosis by Interacting With a Cleaved Form of Urokinase Receptor

Frontiers in Immunology, 2018
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis, alteration in the microvasculature and immunologic abnormalities. It has been hypothesized that an abnormal redox state could regulate the persistent fibrotic phenotype ...
Filomena Napolitano, Francesca Wanda Rossi, Francesca Wanda Rossi, Ada Pesapane, Silvia Varricchio, Gennaro Ilardi, Massimo Mascolo, Stefania Staibano, Antonio Lavecchia, Pia Ragno, Carmine Selleri, Gianni Marone, Gianni Marone, Gianni Marone, Marco Matucci-Cerinic, Marco Matucci-Cerinic, Amato de Paulis, Amato de Paulis, Nunzia Montuori, Nunzia Montuori   +19 more
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STUDY OF THE IMMUNOLOGICAL MARKERS CD49d AND CD38 IN EARLY-STAGE B-CLL PATIENTS [PDF]

Journal of IMAB, 2018
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of B- lymphocytes into the blood stream, primary and secondary lymphoid organs as a consequence of defect in the apoptosis. Most frequently it affects people aged 67- 72. The greater
Vanya Popova, Svetla Blazheva, Tsvetan Lukanov, Silvia Naneva, Nikolay Tzvetkov   +4 more
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Ptr ToxA Interacts with a Chloroplast-Localized Protein

Molecular Plant-Microbe Interactions, 2007
Pyrenophora tritici-repentis, causal agent of tan spot of wheat, produces host-selective toxins that are determinants of pathogenicity or virulence. Ptr ToxA (ToxA), a proteina-ceous toxin produced by P.
Viola A. Manning, Linda K. Hardison, Lynda M. Ciuffetti   +2 more
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Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori

Cell Communication and Signaling, 2011
Helicobacter pylori is a highly successful pathogen uniquely adapted to colonize humans. Gastric infections with this bacterium can induce pathology ranging from chronic gastritis and peptic ulcers to gastric cancer. More virulent H.
Backert Steffen, Clyne Marguerite, Tegtmeyer Nicole   +2 more
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Polymer Thin Film Promotes Tumor Spheroid Formation via JAK2-STAT3 Signaling Primed by Fibronectin-Integrin α5 and Sustained by LMO2-LDB1 Complex

Biomedicines, 2022
Cancer stem-like cells (CSCs) are considered promising targets for anti-cancer therapy owing to their role in tumor progression. Extensive research is, therefore, being carried out on CSCs to identify potential targets for anti-cancer therapy.
Sunyoung Seo, Nayoung Hong, Junhyuk Song, Dohyeon Kim, Yoonjung Choi, Daeyoup Lee, Sangyong Jon, Hyunggee Kim   +7 more
doaj   +1 more source