Results 1 to 10 of about 471,837 (353)

Myosin-X and talin modulate integrin activity at filopodia tips

Cell Reports, 2021
Summary: Filopodia assemble unique integrin-adhesion complexes to sense the extracellular matrix. However, the mechanisms of integrin regulation in filopodia are poorly defined.
Mitro Miihkinen, Max L.B. Grönloh, Ana Popović, Helena Vihinen, Eija Jokitalo, Benjamin T. Goult, Johanna Ivaska, Guillaume Jacquemet   +7 more
doaj   +1 more source

N-glycosylation of ß4 integrin controls the adhesion and motility of keratinocytes. [PDF]

PLoS ONE, 2011
α6ß4 integrin is an essential component of hemidesmosomes and modulates cell migration in wound healing and cancer invasion. To elucidate the role of N-glycosylation on ß4 integrin, we investigated keratinocyte adhesion and migration through the re ...
Yoshinobu Kariya, Jianguo Gu
doaj   +1 more source

Myeloid Poldip2 Contributes to the Development of Pulmonary Inflammation by Regulating Neutrophil Adhesion in a Murine Model of Acute Respiratory Distress Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Lung injury, a severe adverse outcome of lipopolysaccharide‐induced acute respiratory distress syndrome, is attributed to excessive neutrophil recruitment and effector response.
Ziwei Ou, Elena Dolmatova, Rohan Mandavilli, Hongyan Qu, Georgette Gafford, Taylor White, Alejandra Valdivia, Bernard Lassègue, Marina S. Hernandes, Kathy K. Griendling   +9 more
doaj   +1 more source

Calreticulin Regulates β1-Integrin mRNA Stability in PC-3 Prostate Cancer Cells

Biomedicines, 2022
Prostate cancer (PCa) is the major cause of cancer-related death among aging men worldwide. Recent studies have suggested that calreticulin (CRT), a multifunctional chaperon protein, may play an important role in the regulation of PCa tumorigenesis and ...
Yueh-Chien Lin, Yuan-Li Huang, Ming-Hua Wang, Chih-Yu Chen, Wei-Min Chen, Yi-Cheng Weng, Pei-Yi Wu   +6 more
doaj   +1 more source

αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells [PDF]

, 2013
The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM).
Engler, Adam J., Friedrichs, Jens, Manninen, Aki, Matlin, Karl S., Moyano, Jose V., Muller, Daniel J., Myllymäki, Satu M., Strohmeyer, Nico, Teräväinen, Terhi P., Wu, Chuanyue   +9 more
core   +7 more sources

Deiodinase-3 is a thyrostat to regulate podocyte homeostasis

EBioMedicine, 2021
: Background: Nephrotic syndrome (NS) is associated with kidney podocyte injury and may occur as part of thyroid autoimmunity such as Graves’ disease.
Shivangi Agarwal, Kwi Hye Koh, Nicholas J. Tardi, Chuang Chen, Ranadheer Reddy Dande, Joao Pedro WerneckdeCastro, Yashwanth Reddy Sudhini, Cristina Luongo, Domenico Salvatore, Beata Samelko, Mehmet M. Altintas, Steve Mangos, Antonio Bianco, Jochen Reiser   +13 more
doaj   +1 more source

Respiratory Tract Infections in Inflammatory Bowel Disease Patients Taking Vedolizumab: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Frontiers in Pharmacology, 2021
The ongoing COVID-19 pandemic has raised concerns about the risk of SARS-CoV-2 infection in patients with Crohn’s disease (CD) and patients with ulcerative colitis (UC) taking immunosuppressants or biologics.
Irene Marafini, Edoardo Troncone, Irene Rocchetti, Giovanni Monteleone   +3 more
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Targeting of the COX-2/PGE2 axis enhances the antitumor activity of T7 peptide in vitro and in vivo

Drug Delivery, 2021
T7 peptide is considered as an antiangiogenic polypeptide. The presents study aimed to further detect the antiangiogenic mechanisms of T7 peptide and determine whether combining T7 peptide and meloxicam (COX-2/PGE2 specific inhibitor) could offer a ...
Jianrong Yang, Jingtao Zhong, Mi Zhou, Yinghong Zhou, Peng Xiu, Feng Liu, Fuhai Wang, Zelun Li, Yuntian Tang, Yuanyuan Chen, Siyang Yao, Tao Huang, Tianqi Liu, Xiaofeng Dong   +13 more
doaj   +1 more source

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. [PDF]

, 2017
Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The
Bardel, Bernadette, Block, Helena, Bokemeyer, Arne, Boras, Mark, Heitplatz, Barbara, Kliche, Stefanie, Lowell, Clifford, Reinhold, Annegret, Rossaint, Jan, Van Marck, Veerle, Volmering, Stephanie, Zarbock, Alexander   +11 more
core   +2 more sources

Angiogenesis Inhibition by a Short 13 Amino Acid Peptide Sequence of Tetrastatin, the α4(IV) NC1 Domain of Collagen IV

Frontiers in Cell and Developmental Biology, 2020
Angiogenesis is defined as the formation of new capillaries by sprouting from the pre-existing microvasculature. It occurs in physiological and pathological processes particularly in tumor growth and metastasis.
Alexia Vautrin-Glabik, Alexia Vautrin-Glabik, Jérôme Devy, Jérôme Devy, Camille Bour, Camille Bour, Stéphanie Baud, Stéphanie Baud, Stéphanie Baud, Laurence Choulier, Anthony Hoarau, Anthony Hoarau, Aurélie Dupont-Deshorgue, Aurélie Dupont-Deshorgue, Christèle Sellier, Christèle Sellier, Bertrand Brassart, Bertrand Brassart, Jean-Baptiste Oudart, Jean-Baptiste Oudart, Jean-Baptiste Oudart, Laurent Ramont, Laurent Ramont, Laurent Ramont, Jean Claude Monboisse, Jean Claude Monboisse, Jean Claude Monboisse, Sylvie Brassart-Pasco, Sylvie Brassart-Pasco   +28 more
doaj   +1 more source