Results 21 to 30 of about 471,837 (353)

Integrin activation [PDF]

Biochemical Society Transactions, 2008
Agonist stimulation of integrin receptors, composed of transmembrane α and β subunits, leads cells to regulate integrin affinity (‘activation’), a process that controls cell adhesion and migration, and extracellular matrix assembly. A final step in integrin activation is the binding of talin to integrin β cytoplasmic domains.
Asoka, Banno, Mark H, Ginsberg
openaire   +2 more sources

Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development. [PDF]

, 2018
Integrin activation regulates adhesion, extracellular matrix assembly, and cell migration, thereby playing an indispensable role in development and in many pathological processes.
Fan, Zhichao, Gingras, Alexandre R, Ginsberg, Mark H, Lagarrigue, Frederic, Ley, Klaus, Sun, Hao   +5 more
core   +2 more sources

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

Cell, 2019
Our paper identified α V integrins as the cellular receptors for irisin, acting in osteocytes and adipocytes. During figure preparation, we inadvertently duplicated the β -actin western blot image from Figure S6A in Figure S4C.
Hyeonwoo Kim, C. Wrann, Mark P. Jedrychowski, S. Vidoni, Y. Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, V. Parkman, S. Novick, Timothy S. Strutzenberg, B. Pascal, P. Le, D. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, L. Mattheis, Wenjing Chen, H. Tu, M. Bouxsein, P. Griffin, R. Baron, C. Rosen, L. Bonewald, B. Spiegelman   +24 more
semanticscholar   +1 more source

Pathophysiological roles of integrins in gliomas from the perspective of glioma stem cells

Frontiers in Cell and Developmental Biology, 2022
Glioblastoma is the most common primary intracranial tumor and is also one of the most malignant central nervous system tumors. Its characteristics, such as high malignancy, abundant tumor vasculature, drug resistance, and recurrence-prone nature, cause ...
Maoyu Wang, Sen Shen, Feng Hou, Yaohua Yan   +3 more
doaj   +1 more source

Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem. [PDF]

, 2019
Rap1 GTPases bind effectors, such as RIAM, to enable talin1 to induce integrin activation. In addition, Rap1 binds directly to the talin1 F0 domain (F0); however, this interaction makes a limited contribution to integrin activation in CHO cells or ...
Alexandre R. Gingras, Andrew J. Valadez, Anthis, Bromberger, Calderwood, Camp, Critchley, Frederic Lagarrigue, Frojmovic, Gingras, Goult, Haling, Han, Hynes, Klapproth, Klaus Ley, Lagarrigue, Lagarrigue, Lee, Marcus Zorovich, Mark H. Ginsberg, Miguel Alejandro Lopez-Ramirez, Monica N. Cuevas, Nicolas Seban, Nieswandt, O’Toole, Petrich, Petrich, Plak, Shattil, Shattil, Simonson, Song, Stefanini, Stritt, Su, Sun, Tadokoro, Vranken, Wegener, William B. Kiosses, Wilma McLaughlin, Ye, Zeiler, Zhu   +44 more
core   +2 more sources

Shear Stress Induces the Release of an Endothelial Elastase: Role in Integrin alpha(v)beta(3)-Mediated FGF-2 Release [PDF]

, 2011
Background/Aims: Laminar shear stress is an important stimulus in the endothelium-dependent control of vascular tone and of vascular remodeling processes.
Gloe, Torsten, Hennig, Theres, Kirsch, Julian, Mogensen, Christina, Pohl, Ulrich   +4 more
core   +1 more source

Tubulointerstitial de novo expression of the α8 integrin chain in a rodent model of renal fibrosis--a potential target for anti-fibrotic therapy?

PLoS ONE, 2012
In the normal kidney, the α8 integrin chain is expressed only on mesangial cells and vascular smooth muscle cells. α8 integrin ligates several matrix molecules including fibronectin, osteopontin and fibrillin-1.
Andrea Hartner, Carlos Menendez-Castro, Nada Cordasic, Ines Marek, Gudrun Volkert, Bernd Klanke, Wolfgang Rascher, Karl F Hilgers   +7 more
doaj   +1 more source

PP2A methylesterase PME‐1 suppresses anoikis and is associated with therapy relapse of PTEN‐deficient prostate cancers

Molecular Oncology, 2023
While organ‐confined prostate cancer (PCa) is mostly therapeutically manageable, metastatic progression of PCa remains an unmet clinical challenge.
Anna Aakula, Aleksi Isomursu, Christian Rupp, Andrew Erickson, Nikhil Gupta, Otto Kauko, Pragya Shah, Artur Padzik, Yuba Raj Pokharel, Amanpreet Kaur, Song‐Ping Li, Lloyd Trotman, Pekka Taimen, Antti Rannikko, Jan Lammerding, Ilkka Paatero, Tuomas Mirtti, Johanna Ivaska, Jukka Westermarck   +18 more
doaj   +1 more source

Integrin-mediated mechanotransduction

Journal of Cell Biology, 2016
Sun, Guo, and Fässler review the function and regulation of integrin-mediated mechanotransduction and discuss how its dysregulation impacts cancer progession.
Zhiqi Sun, Shengzhen S Guo, R. Fässler
semanticscholar   +1 more source

Win, Lose, or Tie: Mathematical Modeling of Ligand Competition at the Cell–Extracellular Matrix Interface

Frontiers in Bioengineering and Biotechnology, 2021
Integrin transmembrane proteins conduct mechanotransduction at the cell–extracellular matrix (ECM) interface. This process is central to cellular homeostasis and therefore is particularly important when designing instructive biomaterials and organoid ...
Zeynep Karagöz, Thomas Geuens, Vanessa L. S. LaPointe, Martijn van Griensven, Aurélie Carlier   +4 more
doaj   +1 more source