Results 21 to 30 of about 202,411 (268)
Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection
Virulence, 2020 Leukocyte function-associated antigen 1 (LFA-1) is the most widely expressed member of the β2 integrin family of cell-cell adhesion molecules. Although LFA-1 is thought to regulate multiple aspects of T cell immunity, its role in the response of CD8+ T ...
Mario Perro +3 more
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Nascent Adhesion Clustering: Integrin-Integrin and Integrin-Substrate Interactions [PDF]
Biophysica, 2022 Nascent adhesions (NAs) are a general precursor to the formation of focal adhesions (FAs) that provide a fundamental mechanism for cell adhesion that is, in turn, involved in cell proliferation, migration, and mechanotransduction. Nascent adhesions form when cells come into contact with substrates at all rigidities and generally involve the clustering ...
Kuanpo Lin, Robert J. Asaro
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Frontiers in Immunology, 2018 Integrin α5β1 is a crucial adhesion molecule that mediates the adherence of many cell types to the extracellular matrix through recognition of its classic ligand fibronectin as well as to other cells through binding to an alternative counter-receptor ...
Yesenia Machado-Pineda +16 more
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CD11b Signaling Prevents Chondrocyte Mineralization and Attenuates the Severity of Osteoarthritis
Frontiers in Cell and Developmental Biology, 2020 Osteoarthritis (OA) is a progressive joint disease that is strongly associated with calcium-containing crystal formation (mineralization) by chondrocytes leading ultimately to cartilage calcification.
Driss Ehirchiou +8 more
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Prokaryotic Collagen-Like Proteins as Novel Biomaterials
Frontiers in Bioengineering and Biotechnology, 2022 Collagens are the major structural component in animal extracellular matrices and are critical signaling molecules in various cell-matrix interactions. Its unique triple helical structure is enabled by tripeptide Gly-X-Y repeats.
Jonathan Picker +6 more
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Integrins, cancer and snake toxins (mini-review)
Journal of Venomous Animals and Toxins including Tropical Diseases, 2005 Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM).
G. Rádis-Baptista
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Integrins and p53 pathways in glioblastoma resistance to temozolomide
Frontiers in Oncology, 2012 Glioblastoma is the most common malignant primary brain tumor. Surgical resection, postoperative radiotherapy plus concomitant and adjuvant chemotherapy with temozolomide is the standard of care for newly diagnosed glioblastoma.
Monique eDontenwill +2 more
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Frontiers in Cell and Developmental BiologyHepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide and the most common primary tumor. Periostin (POSTN) is located in the extracellular matrix (ECM) and triggers tumor growth signals by binding to integrin receptors.
Jun Lei +4 more
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The Role of the Extracellular Matrix in Cancer Stemness
Frontiers in Cell and Developmental Biology, 2019 As our understanding of cancer cell biology progresses, it has become clear that tumors are a heterogenous mixture of different cell populations, some of which contain so called “cancer stem cells” (CSCs).
Sameera Nallanthighal +2 more
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Regulatory Mechanism of ITGBL1 in the Metastasis of Colorectal Cancer
Frontiers in Oncology, 2020 Integrin, beta-like 1 (ITGBL1) protein is located in the extracellular matrix (ECM) and involved in the development and metastasis of many tumors. However, the regulatory mechanism of ITGBL1 in colorectal cancer (CRC) remains unclear.
Lu Qi +8 more
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