Results 21 to 30 of about 266,162 (304)

Integrins in Mechanotransduction [PDF]

Journal of Biological Chemistry, 2004
Mechanical forces are crucial to the regulation of cell and tissue morphology and function. At the cellular level, forces influence cytoskeletal organization, gene expression, proliferation, and survival. Integrin-mediated adhesions are intrinsically mechanosensitive and a large body of data implicates integrins in sensing mechanical forces.
Akira, Katsumi, A Wayne, Orr, Eleni, Tzima, Martin Alexander, Schwartz   +3 more
openaire   +2 more sources

Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes [PDF]

, 2007
Adhesion molecules of the integrin beta1 family are thought to be involved in the malignant progression renal cell carcinoma (RCC). Still, it is not clear how they contribute to this process.
Jones, Jon, Jüngel, Eva, Dietger Jonas, Blaheta, Roman A., Roman A.Blaheta, Stefan Berkhoff, Tobias Engl, Wedel, Steffen Alexander, Jonas, Dietger, Berkhoff, Stefan, Jon Jones, Borna Relja, Relja, Borna, Eva Weich, Steffen Wedel, Engl, Tobias A.   +15 more
core   +1 more source

Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation [PDF]

, 2011
Physiological as well as pathological blood vessel formation are fundamentally dependent on cell-matrix interaction. Integrins, a family of major cell adhesion receptors, play a pivotal role in development, maintenance, and remodeling of the vasculature.
Stephan Niland, Eble, Johannes A., Niland, Stephan, Johannes A. Eble   +3 more
core   +1 more source

Integrin activation [PDF]

BMB Reports, 2014
Integrin-mediated cell adhesion is important for development, immune responses, hemostasis and wound healing. Integrins also function as signal transducing receptors that can control intracellular pathways that regulate cell survival, proliferation, and cell fate.
openaire   +4 more sources

Win, Lose, or Tie: Mathematical Modeling of Ligand Competition at the Cell–Extracellular Matrix Interface

Frontiers in Bioengineering and Biotechnology, 2021
Integrin transmembrane proteins conduct mechanotransduction at the cell–extracellular matrix (ECM) interface. This process is central to cellular homeostasis and therefore is particularly important when designing instructive biomaterials and organoid ...
Zeynep Karagöz, Thomas Geuens, Vanessa L. S. LaPointe, Martijn van Griensven, Aurélie Carlier   +4 more
doaj   +1 more source

Therapeutic targeting of Integrin v 6 in breast cancer [PDF]

, 2014
BACKGROUND: Integrin ?v?6 promotes migration, invasion, and survival of cancer cells; however, the relevance and role of ?v?6 has yet to be elucidated in breast cancer.METHODS: Protein expression of integrin subunit beta6 (?6) was measured in breast ...
Thomas, GJ, Louise Jones, J., Eccles, D, Hart, I. R. (Ian R.), Kendrew, Jane, Chou, Patrick, Gillett, C., Jordan, L, Violette, S., Brentnall, A., Duffy, S.W., Warwick, J., Thomas, Gareth J., Saha, A, Hart, I.R., Bowen, R, Barry, S.T., Green, Andrew R, Gillett, Cheryl, Vallath, S, Bowen, R., Haider, Syed, Barry, Simon T, Moore, K.M., Hart, Ian R., Barry, Simon T., Gabe, R., Haider, S., Chelala, C, Jones, J.L., Thomas, Gareth J, Chelala, C., Eccles, Diana, Ellis, Ian O, Kendrew, J., Green, Andrew R., Weinreb, PH, Jones, JL, Chou, P, Vallath, S., Marshall, John F., Jordan, L., Brouilette, Kellie, Kendrew, J, Duffy, Stephen W, Ellis, I.O., Quinlan, P., Quinlan, P, Gabe, R, Haider, S, Moore, Kate M, Jordan, Lee, Hart, Ian R, Marshall, J.F., Brentnall, Adam, Moore, KM, Jones, J. Louise, Barry, ST, Gillett, C, Warwick, J, Thompson, Alastair M, Weinreb, Paul H, Vallath, Sabari, Chou, P., Green, AR, Thompson, A.M., Thompson, AM, Saha, Antonio, Violette, Sheila, Tapper, W.J., Hart, IR, Ellis, IO, Jones, J Louise, Tapper, William J., Brentnall, A, Weinreb, P.H., Brouilette, K., Tapper, Will, Gabe, Rhian, Thompson, Alastair M., Saha, A., Eccles, D., Violette, Shelia, Tapper, William J, Marshall, JF, Thomas, G J., Weinreb, Paul H., Duffy, Stephen W., Moore, Kate M., Brouilette, K, Green, A.R., Quinlan, Phillip, Duffy, SW, Ellis, Ian, Warwick, Jane, Marshall, John F, Bowen, Rebecca, Chelala, Claude, Tapper, WJ, Violette, S, Ellis, Ian O.   +100 more
core   +1 more source

Glycosynapses: microdomains controlling carbohydrate-dependent cell adhesion and signaling

Anais da Academia Brasileira de Ciências, 2004
The concept of microdomains in plasma membranes was developed over two decades, following observation of polarity of membrane based on clustering of specific membrane components.
Senitiroh Hakomori
doaj   +1 more source

The role of NCAM signaling and its effector protein, [beta]1-integrin, in tumor progression [PDF]

, 2007
Neural Cell Adhesion Molecule (NCAM) is a member of the large family of Ca2+independent, immunoglobulin (Ig)-like cell adhesion molecules. So far, its function in homophilic and heterophilic interactions has been mainly studied in neuronal cells, where ...
Kren, Angelika
core   +1 more source

Selection and Characterization of an α6β4 Integrin blocking DNA Aptamer

Molecular Therapy: Nucleic Acids, 2016
The heterodimeric laminin receptor α6β4 integrin plays a central role in the promotion of tumor cell growth, invasion, and organotropic metastasis. As an overproduction of the integrin is often linked to a poor prognosis, the inhibition of integrin α6β4 ...
Katharina Berg, Tobias Lange, Florian Mittelberger, Udo Schumacher, Ulrich Hahn   +4 more
doaj   +1 more source

Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection

Virulence, 2020
Leukocyte function-associated antigen 1 (LFA-1) is the most widely expressed member of the β2 integrin family of cell-cell adhesion molecules. Although LFA-1 is thought to regulate multiple aspects of T cell immunity, its role in the response of CD8+ T ...
Mario Perro, Matteo Iannacone, Ulrich H. von Andrian, Antonio Peixoto   +3 more
doaj   +1 more source