Results 11 to 20 of about 471,837 (353)
BMB Reports, 2014 Integrin-mediated cell adhesion is important for development, immune responses, hemostasis and wound healing. Integrins also function as signal transducing receptors that can control intracellular pathways that regulate cell survival, proliferation, and ...
Ginsberg, Mark H
core +6 more sources
Targeting integrin pathways: mechanisms and advances in therapy
Signal Transduction and Targeted Therapy, 2023 Integrins are considered the main cell-adhesion transmembrane receptors that play multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in biochemical and mechanical signals between cells and their environment in a wide ...
Xiaocong Pang +9 more
semanticscholar +1 more source
Emerging therapeutic opportunities for integrin inhibitors
Nature reviews. Drug discovery, 2021 Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted integrins αIIbβ3, α4β7/α4β1 and αLβ2 for cardiovascular diseases, inflammatory bowel disease ...
R. Slack +4 more
semanticscholar +1 more source
Cell and Tissue Research, 2009 Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. The integrin family is composed of 24 alphabeta heterodimeric members that mediate the attachment of cells to the extracellular matrix (ECM) but that also take part in specialized cell-cell interactions.
Barczyk, Malgorzata +2 more
openaire +2 more sources
Nascent Adhesion Clustering: Integrin-Integrin and Integrin-Substrate Interactions [PDF]
Biophysica, 2022 Nascent adhesions (NAs) are a general precursor to the formation of focal adhesions (FAs) that provide a fundamental mechanism for cell adhesion that is, in turn, involved in cell proliferation, migration, and mechanotransduction. Nascent adhesions form when cells come into contact with substrates at all rigidities and generally involve the clustering ...
Kuanpo Lin, Robert J. Asaro
openaire +2 more sources
Journal of Cell Science, 2006 Cell adhesion, migration and the maintenance of cell polarity are all processes that depend on the correct targeting of integrins and the dynamic remodelling of integrin-containing adhesion sites. The importance of the endo/exocytic cycle of integrins as a key regulator of these functions is increasingly recognized.
Ivaska, Johanna, Pellinen, Teijo
openaire +2 more sources
Genome Biology, 2007 The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane alphabeta heterodimers and at least 18 alpha and eight beta subunits are known in humans, generating 24 heterodimers.
Takada, Yoshikazu +2 more
openaire +4 more sources
A role for Syk-kinase in the control of the binding cycle of the β2 integrins (CD11/CD18) in human polymorphonuclear neutrophils [PDF]
, 2003 A fine control of β2 integrin (CD11/CD18)-mediated firm adhesion of human neutrophils to the endothelial cell monolayer is required to allow ordered emigration.
Arnaout +47 more
core +1 more source
Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. [PDF]
, 2019 Thrombospondins (Thbs) are a family of five secreted matricellular glycoproteins in vertebrates that broadly affect cell-matrix interaction. While Thbs4 is known to protect striated muscle from disease by enhancing sarcolemmal stability through increased
Brody, Matthew J +11 more
core +3 more sources
Cancer Cell, 2019 Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor cells with the ability to proliferate without restraint, to invade through ...
Jonathan M Cooper, F. Giancotti
semanticscholar +1 more source