Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes [PDF]
, 2007 Adhesion molecules of the integrin beta1 family are thought to be involved in the malignant progression renal cell carcinoma (RCC). Still, it is not clear how they contribute to this process.
Achiwa H +10 more
core +1 more source
Glycosynapses: microdomains controlling carbohydrate-dependent cell adhesion and signaling
Anais da Academia Brasileira de Ciências, 2004 The concept of microdomains in plasma membranes was developed over two decades, following observation of polarity of membrane based on clustering of specific membrane components.
Senitiroh Hakomori
doaj +1 more source
Laminin receptors in the retina: sequence analysis of the chick integrin alpha 6 subunit. Evidence for transcriptional and posttranslational regulation. [PDF]
, 1991 The integrin alpha 6 beta 1 is a prominent laminin receptor used by many cell types. In the present work, we isolate clones and determine the primary sequence of the chick integrin alpha 6 subunit.
de Curtis, I +3 more
core +3 more sources
Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting
Journal of Hematology & Oncology, 2019 Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit bioinformation bidirectionally across the plasma membrane.
Jian-song Huang +17 more
semanticscholar +1 more source
Integrin‐dependent pathologies [PDF]
The Journal of Pathology, 2003 AbstractCell adhesion and migration are essential for embryonic development, tissue regeneration, and immune defence. The physical link between the extracellular substrate and the actin cytoskeleton is mediated by receptors of the integrin family and a large set of adaptor proteins.
Wehrle-Haller, Bernhard, Imhof, Beat
openaire +3 more sources
Selection and Characterization of an α6β4 Integrin blocking DNA Aptamer
Molecular Therapy: Nucleic Acids, 2016 The heterodimeric laminin receptor α6β4 integrin plays a central role in the promotion of tumor cell growth, invasion, and organotropic metastasis. As an overproduction of the integrin is often linked to a poor prognosis, the inhibition of integrin α6β4 ...
Katharina Berg +4 more
doaj +1 more source
Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection
Virulence, 2020 Leukocyte function-associated antigen 1 (LFA-1) is the most widely expressed member of the β2 integrin family of cell-cell adhesion molecules. Although LFA-1 is thought to regulate multiple aspects of T cell immunity, its role in the response of CD8+ T ...
Mario Perro +3 more
doaj +1 more source
Frontiers in Immunology, 2018 Integrin α5β1 is a crucial adhesion molecule that mediates the adherence of many cell types to the extracellular matrix through recognition of its classic ligand fibronectin as well as to other cells through binding to an alternative counter-receptor ...
Yesenia Machado-Pineda +16 more
doaj +1 more source
α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. [PDF]
, 2017 Tumors are fibrotic and characterized by abundant, remodeled, and cross-linked collagen that stiffens the extracellular matrix stroma. The stiffened collagenous stroma fosters malignant transformation of the tissue by increasing tumor cell tension to ...
Cassereau, L +11 more
core +2 more sources
CD11b Signaling Prevents Chondrocyte Mineralization and Attenuates the Severity of Osteoarthritis
Frontiers in Cell and Developmental Biology, 2020 Osteoarthritis (OA) is a progressive joint disease that is strongly associated with calcium-containing crystal formation (mineralization) by chondrocytes leading ultimately to cartilage calcification.
Driss Ehirchiou +8 more
doaj +1 more source