Results 31 to 40 of about 272,677 (316)

Win, Lose, or Tie: Mathematical Modeling of Ligand Competition at the Cell–Extracellular Matrix Interface

Frontiers in Bioengineering and Biotechnology, 2021
Integrin transmembrane proteins conduct mechanotransduction at the cell–extracellular matrix (ECM) interface. This process is central to cellular homeostasis and therefore is particularly important when designing instructive biomaterials and organoid ...
Zeynep Karagöz, Thomas Geuens, Vanessa L. S. LaPointe, Martijn van Griensven, Aurélie Carlier   +4 more
doaj   +1 more source

Integrins in Mechanotransduction [PDF]

Journal of Biological Chemistry, 2004
Mechanical forces are crucial to the regulation of cell and tissue morphology and function. At the cellular level, forces influence cytoskeletal organization, gene expression, proliferation, and survival. Integrin-mediated adhesions are intrinsically mechanosensitive and a large body of data implicates integrins in sensing mechanical forces.
Akira, Katsumi, A Wayne, Orr, Eleni, Tzima, Martin Alexander, Schwartz   +3 more
openaire   +2 more sources

αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells [PDF]

, 2013
The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM).
Muller, Daniel J, Myllymäki, Satu M., Jens Friedrichs, Aki Manninen (221960), Matlin, Karl S., Daniel J. Muller (2509858), Manninen, Aki, Myllymäki Satu M., Manninen Aki, Jose V Moyano, Strohmeyer, Nico; id_orcid, Teräväinen, Terhi P, Muller Daniel J., Terhi P. Teräväinen (447383), Jens Friedrichs (447385), Muller, Daniel J., Satu M Myllymäki, Engler, Adam J., Friedrichs Jens, Chuanyue Wu (196653), Satu M. Myllymäki (447384), Strohmeyer, Nico, Nico Strohmeyer (447386), Karl S. Matlin (447388), Moyano, Jose V, Teräväinen, Terhi P., Terhi P Teräväinen, Karl S Matlin, Chuanyue Wu, Wu, Chuanyue, Moyano, Jose V., Strohmeyer Nico, Myllymäki, Satu M, Aki Manninen, Daniel J Muller, Jose V. Moyano (447387), Matlin Karl S., Wu Chuanyue, Moyano Jose V., Nico Strohmeyer, Matlin, Karl S, Friedrichs, Jens, Teräväinen Terhi P.   +42 more
core   +2 more sources

Glycosynapses: microdomains controlling carbohydrate-dependent cell adhesion and signaling

Anais da Academia Brasileira de Ciências, 2004
The concept of microdomains in plasma membranes was developed over two decades, following observation of polarity of membrane based on clustering of specific membrane components.
Senitiroh Hakomori
doaj   +1 more source

Integrin activation [PDF]

BMB Reports, 2014
Integrin-mediated cell adhesion is important for development, immune responses, hemostasis and wound healing. Integrins also function as signal transducing receptors that can control intracellular pathways that regulate cell survival, proliferation, and cell fate.
openaire   +4 more sources

Cdc42 promotes transendothelial migration of cancer cells through β1 integrin. [PDF]

, 2012
Cancer cells interact with endothelial cells during the process of metastatic spreading. Here, we use a small interfering RNA screen targeting Rho GTPases in cancer cells to identify Cdc42 as a critical regulator of cancer cell-endothelial cell ...
Valderrama, F, Riou, P, Susan Cox, Garg, Ritu, Vega, FM, Im, Jae Hong, Im, JH, Valderrama, Ferran, Ritu Garg, Muschel, Ruth J, Ridley, Anne J, Garg, R, Cox, Susan, Barbara Borda d’Agua, Cox, S, Vega, Francisco M., d'Agua, Barbara Borda, Reymond, N, Nicolas Reymond, Philippe Riou, Borda d'Agua, Barbara, Ferran Valderrama, Reymond, Nicolas, Jae Hong Im, Riou, Philippe, Muschel, Ruth J., Borda d'Agua, B, Ridley, AJ, Francisco M. Vega, Muschel, RJ, Anne J. Ridley, Ridley, Anne J., Vega, Francisco M, Ruth J. Muschel   +33 more
core   +1 more source

The role of NCAM signaling and its effector protein, [beta]1-integrin, in tumor progression [PDF]

, 2007
Neural Cell Adhesion Molecule (NCAM) is a member of the large family of Ca2+independent, immunoglobulin (Ig)-like cell adhesion molecules. So far, its function in homophilic and heterophilic interactions has been mainly studied in neuronal cells, where ...
Kren, Angelika
core   +1 more source

Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection

Virulence, 2020
Leukocyte function-associated antigen 1 (LFA-1) is the most widely expressed member of the β2 integrin family of cell-cell adhesion molecules. Although LFA-1 is thought to regulate multiple aspects of T cell immunity, its role in the response of CD8+ T ...
Mario Perro, Matteo Iannacone, Ulrich H. von Andrian, Antonio Peixoto   +3 more
doaj   +1 more source

Shear Stress Induces the Release of an Endothelial Elastase: Role in Integrin alpha(v)beta(3)-Mediated FGF-2 Release [PDF]

, 2011
Background/Aims: Laminar shear stress is an important stimulus in the endothelium-dependent control of vascular tone and of vascular remodeling processes.
Hennig, Theres, Christina Mogensen, Gloe, Torsten, Kirsch, Julian, Julian Kirsch, Torsten Gloe, Ulrich Pohl, Pohl, Ulrich, Theres Hennig, Mogensen, Christina   +9 more
core   +1 more source

Selection and Characterization of an α6β4 Integrin blocking DNA Aptamer

Molecular Therapy: Nucleic Acids, 2016
The heterodimeric laminin receptor α6β4 integrin plays a central role in the promotion of tumor cell growth, invasion, and organotropic metastasis. As an overproduction of the integrin is often linked to a poor prognosis, the inhibition of integrin α6β4 ...
Katharina Berg, Tobias Lange, Florian Mittelberger, Udo Schumacher, Ulrich Hahn   +4 more
doaj   +1 more source