Results 41 to 50 of about 266,162 (304)
Modulation of integrin activity for diagnostic and therapeutic applications [PDF]
, 2010 SUMMARY Over the past decade, the scientific research spent many efforts to develop therapeutic and diagnostic systems able to contact selectively the target cells and to minimize their diffusion in healthy organs.
De Simone, Mariarosaria
core +1 more source
ß1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli [PDF]
, 2005 Integrins are cell adhesion receptors which mediate interactions between the extracellular matrix and the actin cytoskeleton. They are heterodimers composed of α and β subunits. As adhesion receptors, integrins are important for cell-cell and cell-matrix
Li, Na
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Frontiers in Cell and Developmental BiologyHepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide and the most common primary tumor. Periostin (POSTN) is located in the extracellular matrix (ECM) and triggers tumor growth signals by binding to integrin receptors.
Jun Lei +4 more
doaj +1 more source
The Role of the Extracellular Matrix in Cancer Stemness
Frontiers in Cell and Developmental Biology, 2019 As our understanding of cancer cell biology progresses, it has become clear that tumors are a heterogenous mixture of different cell populations, some of which contain so called “cancer stem cells” (CSCs).
Sameera Nallanthighal +2 more
doaj +1 more source
Regulatory Mechanism of ITGBL1 in the Metastasis of Colorectal Cancer
Frontiers in Oncology, 2020 Integrin, beta-like 1 (ITGBL1) protein is located in the extracellular matrix (ECM) and involved in the development and metastasis of many tumors. However, the regulatory mechanism of ITGBL1 in colorectal cancer (CRC) remains unclear.
Lu Qi +8 more
doaj +1 more source
Integrins and metastasis [PDF]
Cell Adhesion & Migration, 2013 Metastasis is a combination of biological events that makes the difference between cancer and other diseases. Metastasis requires flow of erroneous but precisely coordinated basic cellular activities like cell migration-invasion, cell survival-apoptosis, cell proliferation, etc. All of these processes require efficient regulation of cell attachment and
Kirat Kumar, Ganguly +3 more
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
A role for Syk-kinase in the control of the binding cycle of the β2 integrins (CD11/CD18) in human polymorphonuclear neutrophils [PDF]
, 2003 A fine control of β2 integrin (CD11/CD18)-mediated firm adhesion of human neutrophils to the endothelial cell monolayer is required to allow ordered emigration.
Walzog, Barbara +4 more
core +1 more source
Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6
Advanced ScienceInside‐out and outside‐in activations of integrin both play important roles in adhesion formation and cell motility. While such mechanisms of RGD‐binding integrin, including integrin β1 and β3, are well documented, mechanosensitive regulations of ...
Wan Ning Lee +3 more
doaj +1 more source