Results 41 to 50 of about 245,645 (318)

CD9 Controls Integrin α5β1-Mediated Cell Adhesion by Modulating Its Association With the Metalloproteinase ADAM17

Frontiers in Immunology, 2018
Integrin α5β1 is a crucial adhesion molecule that mediates the adherence of many cell types to the extracellular matrix through recognition of its classic ligand fibronectin as well as to other cells through binding to an alternative counter-receptor ...
Yesenia Machado-Pineda, Beatriz Cardeñes, Raquel Reyes, Soraya López-Martín, Soraya López-Martín, Víctor Toribio, Víctor Toribio, Paula Sánchez-Organero, Henar Suarez, Henar Suarez, Joachim Grötzinger, Inken Lorenzen, María Yáñez-Mó, María Yáñez-Mó, María Yáñez-Mó, Carlos Cabañas, Carlos Cabañas   +16 more
doaj   +1 more source

Shear Stress Induces the Release of an Endothelial Elastase: Role in Integrin alpha(v)beta(3)-Mediated FGF-2 Release [PDF]

, 2011
Background/Aims: Laminar shear stress is an important stimulus in the endothelium-dependent control of vascular tone and of vascular remodeling processes.
Hennig, Theres, Christina Mogensen, Gloe, Torsten, Kirsch, Julian, Julian Kirsch, Torsten Gloe, Ulrich Pohl, Pohl, Ulrich, Theres Hennig, Mogensen, Christina   +9 more
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CD11b Signaling Prevents Chondrocyte Mineralization and Attenuates the Severity of Osteoarthritis

Frontiers in Cell and Developmental Biology, 2020
Osteoarthritis (OA) is a progressive joint disease that is strongly associated with calcium-containing crystal formation (mineralization) by chondrocytes leading ultimately to cartilage calcification.
Driss Ehirchiou, Ilaria Bernabei, Véronique Chobaz, Mariela Castelblanco, Thomas Hügle, Alexander So, Li Zhang, Nathalie Busso, Sonia Nasi   +8 more
doaj   +1 more source

Prokaryotic Collagen-Like Proteins as Novel Biomaterials

Frontiers in Bioengineering and Biotechnology, 2022
Collagens are the major structural component in animal extracellular matrices and are critical signaling molecules in various cell-matrix interactions. Its unique triple helical structure is enabled by tripeptide Gly-X-Y repeats.
Jonathan Picker, Ziyang Lan, Srishtee Arora, Mykel Green, Mariah Hahn, Elizabeth Cosgriff-Hernandez, Magnus Hook   +6 more
doaj   +1 more source

Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells [PDF]

, 2009
Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, <i>Nrp1</i> null embryos display vascular defects that differ from those of mice lacking ...
Caccavari, Francesca, Valdembri, D., Serini, G., Valdembri, Donatella, Caccavari, F., Caswell Patrick T, Anderson, K.I., Humphries, M.J., Patrick T Caswell, Anderson Kurt I, Anderson, Kurt I., Serini, Guido, Caccavari Francesca, Federico Bussolino, Elena Astanina, Valdembri Donatella, König, I., König, Ireen, Astanina, Elena, Schwarz, J.P., Francesca Caccavari, Jim C Norman, Humphries Martin J, Bussolino, F., Schwarz Juliane P, Guido Serini, Serini Guido, König Ireen, Schwarz, Juliane P., Bussolino, Federico, Kurt I Anderson, Humphries, Martin J., Caswell, Patrick T.; id_orcid, Norman, Jim C., Juliane P Schwarz, Astanina Elena, Astanina, E., Bussolino Federico, Norman, J.C., Donatella Valdembri, Caswell, P.T., Ireen König, Norman Jim C, Martin J Humphries   +43 more
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Integrins, cancer and snake toxins (mini-review)

Journal of Venomous Animals and Toxins including Tropical Diseases, 2005
Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM).
G. Rádis-Baptista
doaj   +1 more source

ß1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli [PDF]

, 2005
Integrins are cell adhesion receptors which mediate interactions between the extracellular matrix and the actin cytoskeleton. They are heterodimers composed of α and β subunits. As adhesion receptors, integrins are important for cell-cell and cell-matrix
Li, Na
core   +1 more source

αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells [PDF]

, 2013
The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM).
Muller, Daniel J, Myllymäki, Satu M., Jens Friedrichs, Aki Manninen (221960), Matlin, Karl S., Daniel J. Muller (2509858), Manninen, Aki, Myllymäki Satu M., Manninen Aki, Jose V Moyano, Strohmeyer, Nico; id_orcid, Teräväinen, Terhi P, Muller Daniel J., Terhi P. Teräväinen (447383), Jens Friedrichs (447385), Muller, Daniel J., Satu M Myllymäki, Engler, Adam J., Friedrichs Jens, Chuanyue Wu (196653), Satu M. Myllymäki (447384), Strohmeyer, Nico, Nico Strohmeyer (447386), Karl S. Matlin (447388), Moyano, Jose V, Teräväinen, Terhi P., Terhi P Teräväinen, Karl S Matlin, Chuanyue Wu, Wu, Chuanyue, Moyano, Jose V., Strohmeyer Nico, Myllymäki, Satu M, Aki Manninen, Daniel J Muller, Jose V. Moyano (447387), Matlin Karl S., Wu Chuanyue, Moyano Jose V., Nico Strohmeyer, Matlin, Karl S, Friedrichs, Jens, Teräväinen Terhi P.   +42 more
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Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes

, 2007
Adhesion molecules of the integrin beta1 family are thought to be involved in the malignant progression renal cell carcinoma (RCC). Still, it is not clear how they contribute to this process.
Jones, Jon, Jüngel, Eva, Dietger Jonas, Blaheta, Roman A., Roman A.Blaheta, Stefan Berkhoff, Tobias Engl, Wedel, Steffen Alexander, Jonas, Dietger, Berkhoff, Stefan, Jon Jones, Borna Relja, Relja, Borna, Eva Weich, Steffen Wedel, Engl, Tobias A.   +15 more
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Integrins and p53 pathways in glioblastoma resistance to temozolomide

Frontiers in Oncology, 2012
Glioblastoma is the most common malignant primary brain tumor. Surgical resection, postoperative radiotherapy plus concomitant and adjuvant chemotherapy with temozolomide is the standard of care for newly diagnosed glioblastoma.
Monique eDontenwill, Sophie eMartin, Hana eJanouskova   +2 more
doaj   +1 more source