Results 51 to 60 of about 245,645 (318)

Cdc42 promotes transendothelial migration of cancer cells through β1 integrin.

, 2012
Cancer cells interact with endothelial cells during the process of metastatic spreading. Here, we use a small interfering RNA screen targeting Rho GTPases in cancer cells to identify Cdc42 as a critical regulator of cancer cell-endothelial cell ...
Valderrama, F, Riou, P, Muschel, Ruth, Susan Cox, Garg, Ritu, Vega, FM, Im, Jae Hong, Im, JH, Valderrama, Ferran, Ritu Garg, Muschel, Ruth J, Ridley, Anne J, Garg, R, Cox, Susan, Barbara Borda d’Agua, Cox, S, Vega, Francisco M., d'Agua, Barbara Borda, Reymond, N, Nicolas Reymond, Philippe Riou, Borda d'Agua, Barbara, Ferran Valderrama, Reymond, Nicolas, Jae Hong Im, Riou, Philippe, Muschel, Ruth J., Borda d'Agua, B, Ridley, AJ, Francisco M. Vega, Muschel, RJ, Anne J. Ridley, Ridley, Anne J., Vega, Francisco M, Ruth J. Muschel   +34 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6

Advanced Science
Inside‐out and outside‐in activations of integrin both play important roles in adhesion formation and cell motility. While such mechanisms of RGD‐binding integrin, including integrin β1 and β3, are well documented, mechanosensitive regulations of ...
Wan Ning Lee, Jiamin Li, Nan‐Peng Chen, Cheng‐han Yu   +3 more
doaj   +1 more source

Periostin-integrin signaling in hepatocellular carcinoma: from biological function to clinical application

Frontiers in Cell and Developmental Biology
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide and the most common primary tumor. Periostin (POSTN) is located in the extracellular matrix (ECM) and triggers tumor growth signals by binding to integrin receptors.
Jun Lei, Yong Liu, Shuai Yuan, Xiaxia Yuan, Qi Yuan   +4 more
doaj   +1 more source

The Role of the Extracellular Matrix in Cancer Stemness

Frontiers in Cell and Developmental Biology, 2019
As our understanding of cancer cell biology progresses, it has become clear that tumors are a heterogenous mixture of different cell populations, some of which contain so called “cancer stem cells” (CSCs).
Sameera Nallanthighal, James Patrick Heiserman, Dong-Joo Cheon   +2 more
doaj   +1 more source

Regulatory Mechanism of ITGBL1 in the Metastasis of Colorectal Cancer

Frontiers in Oncology, 2020
Integrin, beta-like 1 (ITGBL1) protein is located in the extracellular matrix (ECM) and involved in the development and metastasis of many tumors. However, the regulatory mechanism of ITGBL1 in colorectal cancer (CRC) remains unclear.
Lu Qi, Lu Qi, Lu Qi, Fuyao Song, Fuyao Song, Fuyao Song, Yanqing Ding, Yanqing Ding, Yanqing Ding   +8 more
doaj   +1 more source

A role for Syk-kinase in the control of the binding cycle of the β2 integrins (CD11/CD18) in human polymorphonuclear neutrophils [PDF]

, 2003
A fine control of β2 integrin (CD11/CD18)-mediated firm adhesion of human neutrophils to the endothelial cell monolayer is required to allow ordered emigration.
Walzog, Barbara, Prange, Peggy, Willeke, Thomas, Zahler, Stefan, Schymeinsky, Jürgen   +4 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Hydrogels Derivatized With Cationic Moieties or Functional Peptides as Efficient Supports for Neural Stem Cells

Frontiers in Neuroscience, 2020
The increasing incidence of neurodegenerative diseases such as Alzheimer’s or Parkinson’s disease represents a significant burden for patients and national health systems.
Kristin Glotzbach, Nils Stamm, Ralf Weberskirch, Andreas Faissner   +3 more
doaj   +1 more source