Results 61 to 70 of about 272,677 (316)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

The leukocyte integrins

Immunology Today, 1989
During the 1980s, various laboratories identified a rare type of patient suffering from recurrent bacterial infections whose neutrophils showed reduced spreading on surfaces. Such leukocyte adhesion deficient (LAD) patients were shown to lack a trio of molecules named either LFA-1, CR3/Mac-1/Mo1, p150,95/CR4 or CD11, CD18 or the leukocyte integrin ...
Kishimoto, T, Larson, R, Corbi, A, Dustin, M, Staunton, D, Springer, T   +5 more
openaire   +5 more sources

Overview of α_vß₃-integrin-specific optoacoustic imaging.

, 2018
Balb/c nude mouse. Axial plane. Tumor margins indicated by white dashed line. A: Optoacoustic image (850 nm). B: Spectrally unmixed αvß3-integrin-specific signal. C: Overlay of A and B.
Maurice Heimer (5815010), Olga Solyanik (802872), Andrei Todica (3592217), Philipp M. Kazmierczak (465021), Georg Keinrath (5815007), Moritz J. Schneider (691201), Clemens C. Cyran (465020), Maximilian F. Reiser (394755), Jens Ricke (74030), Ralf S. Eschbach (691194), Heidrun Hirner-Eppeneder (691199), Neal C. Burton (283941)   +11 more
core   +1 more source

Surface Co-Presentation of BMP-2 and Integrin Selective Ligands at the Nanoscale Favors β1 Integrin Adhesion [PDF]

, 2019
Here we present the use of surface nanopatterning of covalently immobilized BMP-2 and integrin selective ligands to determine the specificity of their interactions in regulating cell adhesion and focal adhesion assembly. Gold nanoparticle arrays carrying
Horst, Kessler, Francesca, Posa, Giorgio, Mori, Ada, Cavalcanti, Elisabeth, Baha-Schwab, Stefanie, Neubauer, Adriana, Di Benedetto, Qiang, Wei, Corinne, Albigès-Rizo, Joachim P., Spatz   +9 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Integrin activation [PDF]

Biochemical Society Transactions, 2008
Agonist stimulation of integrin receptors, composed of transmembrane α and β subunits, leads cells to regulate integrin affinity (‘activation’), a process that controls cell adhesion and migration, and extracellular matrix assembly. A final step in integrin activation is the binding of talin to integrin β cytoplasmic domains.
Asoka, Banno, Mark H, Ginsberg
openaire   +2 more sources

Integrin-dependent osteoblast differentiation.

, 2017
Levels of chondrogenic (A) and osteoblastic (B) mRNA. (C-F) Cell number and osteogenic protein levels in wild type human MSCs (WT) and silenced integrin β1 MSCs (shITGB1) cultured on surfaces of varying stiffness. *P P
Erin M. Lee (3663484), Kathryn Smith (201924), Rene Olivares-Navarrete (663118), Barbara D. Boyan (663120), Sharon L. Hyzy (745981), Joseph K. Williams (3663481), Zvi Schwartz (663119), Ken Gall (3663487), Maryam Doroudi (3663490)   +8 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX

Metabolites, 2018
Hypoxia is a prominent feature of the tumor microenvironment (TME) and cancer cells must dynamically adapt their metabolism to survive in these conditions. A major consequence of metabolic rewiring by cancer cells in hypoxia is the accumulation of acidic
Paul C. McDonald, Mridula Swayampakula, Shoukat Dedhar   +2 more
doaj   +1 more source