Results 81 to 90 of about 245,645 (318)
Integrins in mechanotransduction [PDF]
Current Opinion in Cell Biology, 2013 Forces acting on cells govern many important regulatory events during development, normal physiology, and disease processes. Integrin-mediated adhesions, which transmit forces between the extracellular matrix and the actin cytoskeleton, play a central role in transducing effects of forces to regulate cell functions.
Ross, Tyler D +6 more
openaire +4 more sources
NADPH oxidase (NOX) in the heart : the interplay of NOX-derived ROS in β1-integrin-induced survival signalling [PDF]
, 2011 Moderate levels of reactive oxygen species (ROS) act as mediators in cellular signalling processes. An important source of cardiac ROS is the highly expressed NADPH oxidase (NOX) family isoform NOX2. However, little is known about whether NOX-derived ROS
Rosc-Schlüter, Berit Ines
core +1 more source
Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine
, 2021 c(RGDyK)-based conjugates of gemcitabine (GEM) with the carbonate and carbamate linkages in the 6-OH group of GEM were synthesized for the targeted delivery of GEM to integrin αvβ3, overexpressing cancer cells to increase the stability as well as the ...
Theodora Chatzisideri (11888048) +15 more
core +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX
Metabolites, 2018 Hypoxia is a prominent feature of the tumor microenvironment (TME) and cancer cells must dynamically adapt their metabolism to survive in these conditions. A major consequence of metabolic rewiring by cancer cells in hypoxia is the accumulation of acidic
Paul C. McDonald +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Journal of Cell Science, 2004 The ability of cells to regulate dynamically their adhesion to one another and to the extracellular matrix (ECM) that surrounds them is essential in multicellular organisms. The integrin family of transmembrane adhesion receptors mediates both cell-cell and cell-ECM adhesion.
openaire +2 more sources
Integrins and Integrin-Associated Proteins in the Cardiac Myocyte [PDF]
Circulation Research, 2014 Integrins are heterodimeric, transmembrane receptors that are expressed in all cells, including those in the heart. They participate in multiple critical cellular processes including adhesion, extracellular matrix organization, signaling, survival, and proliferation. Particularly relevant for a contracting muscle cell, integrins are mechanotransducers,
Israeli-Rosenberg, Sharon +3 more
openaire +4 more sources
Acta Chimica Slovenica, 2017 Integrins are plasma membrane proteins, dysfunction frequently result in cancer pathology, so they represent important targets of anti-tumor therapy. Snake venoms are known source of disintegrins (Dis), proteins that specifically bind integrins and thus ...
Zorica Latinović +4 more
doaj +1 more source