Results 91 to 100 of about 245,645 (318)

Overview of α_vß₃-integrin-specific optoacoustic imaging.

, 2018
Balb/c nude mouse. Axial plane. Tumor margins indicated by white dashed line. A: Optoacoustic image (850 nm). B: Spectrally unmixed αvß3-integrin-specific signal. C: Overlay of A and B.
Maurice Heimer (5815010), Olga Solyanik (802872), Andrei Todica (3592217), Philipp M. Kazmierczak (465021), Georg Keinrath (5815007), Moritz J. Schneider (691201), Clemens C. Cyran (465020), Maximilian F. Reiser (394755), Jens Ricke (74030), Ralf S. Eschbach (691194), Heidrun Hirner-Eppeneder (691199), Neal C. Burton (283941)   +11 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung [PDF]

, 2014
Siglec-E is a sialic acid-binding Ig-like lectin expressed on murine myeloid cells. It has recently been shown to function as a negative regulator of ß2-integrin-dependent neutrophil recruitment to the lung following exposure to lipopolysaccharide (LPS).
Hegde, Vikas, Crocker, Paul R., Sarah J. McMillan, Ritu S. Sharma, Vikas Hegde, Paul R. Crocker, McMillan, Sarah J., Sharma, Ritu S., Richards, Hannah E., Hannah E. Richards   +9 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP

eLife, 2020
Inserted (I) domains function as ligand-binding domains in adhesins that support cell adhesion and migration in many eukaryotic phyla. These adhesins include integrin αβ heterodimers in metazoans and single subunit transmembrane proteins in apicomplexans
Dennis Klug, Sarah Goellner, Jessica Kehrer, Julia Sattler, Léanne Strauss, Mirko Singer, Chafen Lu, Timothy A Springer, Friedrich Frischknecht   +8 more
doaj   +1 more source

Investigating the role of alpha 5 beta 1-integrin in fibrotic posterior capsular opacification (PCO)

, 2021
Duncan, Melinda K.Posterior capsular opacification (PCO) is a major complication of cataract surgery. The lens epithelial cells remaining behind post cataract surgery undergo epithelial mesenchymal transition (EMT) and transform into myofibroblasts.
Assakhi, Imane
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Effects of Anti-Integrin Treatment With Vedolizumab on Immune Pathways and Cytokines in Inflammatory Bowel Diseases

Frontiers in Immunology, 2018
Background and aimsDespite proven clinical efficacy of vedolizumab (VDZ) for inducing and maintaining remission in patients with Crohn’s disease (CD) and ulcerative colitis (UC), subgroups of patients have no therapeutic benefit from anti-α4β7 integrin ...
Timo Rath, Ulrike Billmeier, Fulvia Ferrazzi, Michael Vieth, Arif Ekici, Markus F. Neurath, Raja Atreya   +6 more
doaj   +1 more source

Surface Co-Presentation of BMP-2 and Integrin Selective Ligands at the Nanoscale Favors β1 Integrin Adhesion

, 2019
Here we present the use of surface nanopatterning of covalently immobilized BMP-2 and integrin selective ligands to determine the specificity of their interactions in regulating cell adhesion and focal adhesion assembly. Gold nanoparticle arrays carrying
Horst, Kessler, Francesca, Posa, Giorgio, Mori, Ada, Cavalcanti, Elisabeth, Baha-Schwab, Stefanie, Neubauer, Adriana, Di Benedetto, Qiang, Wei, Corinne, Albigès-Rizo, Joachim P., Spatz   +9 more
core   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source