Results 111 to 120 of about 272,677 (316)
Advanced Healthcare Materials, EarlyView.Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang +4 more
wiley +1 more source
Integrin-Linked Kinase Activity Modulates the Pro-Metastatic Behavior of Ovarian Cancer Cells.
, 2016 Epithelial ovarian cancer (EOC) is the most fatal gynecologic cancer in the U.S.,resulting in >14,000 deaths/year. Most women are diagnosed at late stage with widely disseminated intra-peritoneal metastatic disease,resulting in a 5-year survival rate of
Anne Grisoli (5315312) +4 more
core +1 more source
Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization
Advanced Materials, EarlyView.A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab +8 more
wiley +1 more source
Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction
Advanced Materials, EarlyView.The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu +2 more
wiley +1 more source
, 2019 (A) Immunoblot showing total β1-integrin (tITGB1) levels and phosphorylation at Ser785 and Threonine 783 (left) under steady-state conditions and densitometric quantification of total or phosphorylated β1-integrin levels in indicated cell clones (right).
Jerome Jatzlau (8115377) +12 more
core +1 more source
Advanced Materials, EarlyView.In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren +6 more
wiley +1 more source
A Noninvasive Approach to Study Localized Forces in 3D Epithelia
Advanced Materials, EarlyView.Epithelial morphogenesis depends on dynamic mechanical coupling between adhesion complexes and the cytoskeleton, yet its regulation in polarized 3D tissues remains elusive. We developed a noninvasive strategy using cell‐like elastic microbeads to quantify local forces in intact epithelia.
Niels Gouirand +9 more
wiley +1 more source
Charting Endocrine Progenitors Across Species and Organs
Advanced Science, EarlyView.Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing +21 more
wiley +1 more source
Frontiers in OncologyObjectiveUrothelial carcinoma (UC) accounts for more than 90% of all bladder cancers both in humans and dogs. Human and canine UC share many genetic mutations and tumor markers and clinical and therapeutic interventions.
Roberta Lucianò +17 more
doaj +1 more source
Activation of FAK by integrin β4 in an EGFR/Src dependent manner in tumor progression
, 2010 Focal adhesion kinase(FAK)是一種酪胺酸(tyrosine)的磷酸脢，是integrin下游的重要訊息傳遞者。Integrin是由α、β二種次單元經由不同組合而成的雙複合(heterodimer)受體，位於細胞表面，會與細胞外的基質(extracellular matrix)進行交互作用，負責細胞的黏著、移動、增生等重要的功能。先前研究發現integrin和FAK在癌細胞發展中皆扮演重要角色，其中報導顯示integrin β4會透過調節FAK的活性而影響癌細胞的轉移 ...
Tai, Yu-Ling, 戴佑玲
core