Results 101 to 110 of about 272,677 (316)
Expression of integrin β1 by fibroblasts is required for tissue repair in vivo
, 2010 In tissue repair, fibroblasts migrate into the wound to produce and remodel extracellular matrix (ECM). Integrins are believed to be crucial for tissue repair, but their tissue-specific role in this process is poorly understood.
Denton, C.P. +17 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar +2 more
wiley +1 more source
Thy-1 in Integrin Mediated Mechanotransduction
Frontiers in Cell and Developmental Biology, 2019 The glycosylphosphatidylinositol (GPI) anchored glycoprotein Thy-1 has been prevalently expressed on the surface of various cell types. The biological function of Thy-1 ranges from T cell activation, cell adhesion, neurite growth, differentiation ...
Ping Hu, Thomas H. Barker
doaj +1 more source
Advanced Healthcare Materials, EarlyView.The role of viscoelasticity in the invasion of heterogeneous glioblastoma stem cells (GSCs) was investigated with GSCs categorized into subgroups based on molecular profile, as Reactive, Invasive, or Constructive using viscoelastic biomimetic hyaluronan‐oxime hydrogels.
Nicole J. Blaine +4 more
wiley +1 more source
Hemocompatible Glycogen‐Tissue Plasminogen Activator Complexes for Enhanced Blood Clot Dissolution
Advanced Healthcare Materials, EarlyView.Glycogen–heparin‐cRGD nanoparticles enable targeted delivery of tissue plasminogen activator (tPA) to thrombi through activated platelet recognition. The hemocompatible hybrids minimize interactions with blood and immune cells while retaining enzymatic biodegradability.
Nadiia Davydiuk +6 more
wiley +1 more source
Wilms’ tumor gene 17AA(-)/KTS(-)- reduced ability of cancer cell adhesion to fibronectin substratum
Journal of Associated Medical Sciences, 2009 Wilms’tumor gene (WT1) 17AA(-)/KTS(-) isoform alters morphological changes, motility and invasion of cancer cells that may involve in cell attachment to extracellular matrix (ECM) and its receptor integrin subunits.
Tanyarat Jomgeow, Singkome Tima
doaj
eLife, 2018 Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Pirita Pekkonen +17 more
doaj +1 more source
, 2017 High expression of either beta 4 integrin or focal adhesion kinase (FAK) has been reported in human colon cancer. However, it remains unclear how beta 4 integrin together with FAK contributes to the tumorigenicity of colon cancer.
Tai, Yu-Ling;Lai, I-Rue;Peng, Yu-Ju;Ding, Shih-Torng;Shen, Tang-Long +1 more
core +1 more source
Hybrid Biofabrication of a Hierarchically Organized Periosteum‐Inspired In Vitro Platform
Advanced Healthcare Materials, EarlyView.A hybrid biofabrication strategy integrates melt electrowriting with extrusion‐based 3D bioprinting to create a hierarchically organized periosteum‐inspired in vitro platform. Spatially defined osteogenic, fibrous, and endothelial cell‐containing compartments support long‐term culture, osteogenic maturation, and CD31+ endothelial cell organization ...
Yakui Liu +7 more
wiley +1 more source
eLife, 2018 We use the myotendinous junction of Drosophila flight muscles to explore why many integrin associated proteins (IAPs) are needed and how their function is coordinated.
Hannah J Green +3 more
doaj +1 more source