Results 131 to 140 of about 245,645 (318)
Advanced Healthcare Materials, EarlyView.We developed a fully human 3D tonsil cell culture system incorporating supportive stromal cells that better sustains and activates immune cells than conventional methods. The model generates stronger, more targeted antibody responses to viral antigens and vaccines, providing a physiologically relevant and entirely human platform for studying immune ...
Maaike V. J. Braham +11 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett +7 more
wiley +1 more source
Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
Frontiers in OncologyObjectiveUrothelial carcinoma (UC) accounts for more than 90% of all bladder cancers both in humans and dogs. Human and canine UC share many genetic mutations and tumor markers and clinical and therapeutic interventions.
Roberta Lucianò +17 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan +13 more
wiley +1 more source
Expression of αv Integrin in Feline Injection-Site Sarcoma (FISS): Preliminary Investigations
AnimalsFeline injection-site sarcomas (FISSs) are malignant skin tumors of mesenchymal origin arising at local post-vaccination (or injection) sites. In recent years, a fluorescence imaging technique based on probes targeting αvβ3 integrin has been effectively ...
Andrea Cappelleri +7 more
doaj +1 more source
Activation of FAK by integrin β4 in an EGFR/Src dependent manner in tumor progression
, 2010 Focal adhesion kinase(FAK)是一種酪胺酸(tyrosine)的磷酸脢，是integrin下游的重要訊息傳遞者。Integrin是由α、β二種次單元經由不同組合而成的雙複合(heterodimer)受體，位於細胞表面，會與細胞外的基質(extracellular matrix)進行交互作用，負責細胞的黏著、移動、增生等重要的功能。先前研究發現integrin和FAK在癌細胞發展中皆扮演重要角色，其中報導顯示integrin β4會透過調節FAK的活性而影響癌細胞的轉移 ...
Tai, Yu-Ling, 戴佑玲
core
Integrins Mediate Adherence and Migration of T Lymphocytes on Human Peritoneal Mesothelial Cells
, 2011 We previously showed that a local immune response largely composed of type 1 T cells correlated with a favorable outcome of the peritonitis associated with peritoneal dialysis.
王馨慧;李宗諺;林清淵 +1 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez +6 more
wiley +1 more source
Frontiers in Cell and Developmental BiologyThe fusion of epithelial sheets is an essential and conserved morphogenetic event that requires the maintenance of tissue continuity. This is secured by membrane-bound or diffusible signals that instruct the epithelial cells, in a coordinated fashion, to
Katerina Karkali +2 more
doaj +1 more source