Results 21 to 30 of about 105,036 (265)
Irisin supports integrin-mediated cell adhesion of lymphocytes
Biochemistry and Biophysics Reports, 2021 Irisin, a myokine released from skeletal muscle, has recently been found to act as a ligand for the integrins αVβ5, αVβ1, and α5β1 expressed on mesenchymal cells, thereby playing an important role in the metabolic remodeling of the bone, skeletal muscle ...
Phyoe Kyawe Myint +8 more
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Integrins in Mechanotransduction [PDF]
Journal of Biological Chemistry, 2004 Mechanical forces are crucial to the regulation of cell and tissue morphology and function. At the cellular level, forces influence cytoskeletal organization, gene expression, proliferation, and survival. Integrin-mediated adhesions are intrinsically mechanosensitive and a large body of data implicates integrins in sensing mechanical forces.
Akira, Katsumi +3 more
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F1000Research, 2017 While integrins were originally discovered as cell adhesion receptors, recent studies have reinforced the concept that integrins have central roles in cancer that extend far beyond controlling cell adhesion and migration.
Whitney Longmate, C Michael DiPersio
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Integrins, cancer and snake toxins (mini-review)
Journal of Venomous Animals and Toxins including Tropical Diseases, 2005 Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM).
G. Rádis-Baptista
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BMB Reports, 2014 Integrin-mediated cell adhesion is important for development, immune responses, hemostasis and wound healing. Integrins also function as signal transducing receptors that can control intracellular pathways that regulate cell survival, proliferation, and cell fate.
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Integrin activation states and eosinophil recruitment in asthma
Frontiers in Pharmacology, 2013 Eosinophil arrest and recruitment to the airway in asthma are mediated, at least in part, by integrins. Eosinophils express α4β1, α6β1, αLβ2, αMβ2, αXβ2, αDβ2, and α4β7 integrins, which interact with counter-receptors on other cells or ligands in the ...
Mats W Johansson, Deane F Mosher
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Cells, 2022 Smooth muscle cells (SMCs), present in the media layer of blood vessels, are crucial in maintaining vascular homeostasis. Upon vascular injury, SMCs show a high degree of plasticity, undergo a change from a “contractile” to a “synthetic” phenotype, and ...
Manish Jain, Anil K. Chauhan
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Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities
Cell Communication and Signaling, 2023 Integrins are transmembrane receptors that possess distinct ligand-binding specificities in the extracellular domain and signaling properties in the cytoplasmic domain.
Siyi Li +4 more
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Integral Roles for Integrins in γδ T Cell Function
Frontiers in Immunology, 2018 Integrins are adhesion receptors on the cell surface that enable cells to respond to their environment. Most integrins are heterodimers, comprising α and β type I transmembrane glycoprotein chains with large extracellular domains and short cytoplasmic ...
Gabrielle M. Siegers
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Nature Communications, 2023 To enter mitosis, most adherent animal cells reduce adhesion, which is followed by cell rounding. How mitotic cells regulate adhesion to neighboring cells and extracellular matrix (ECM) proteins is poorly understood.
Maximilian Huber +4 more
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