Results 11 to 20 of about 105,036 (265)
The Activation and Regulation of β2 Integrins in Phagocytes and Phagocytosis
Frontiers in Immunology, 2021 Phagocytes, which include neutrophils, monocytes, macrophages, and dendritic cells, protect the body by removing foreign particles, bacteria, and dead or dying cells.
Hao Sun +3 more
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The relative importance of platelet integrins in hemostasis, thrombosis and beyond
Haematologica, 2023 Integrins are heterodimeric transmembrane receptors composed of α and β chains, with an N-terminal extracellular domain forming a globular head corresponding to the ligand binding site.
Emily Janus-Bell, Pierre H. Mangin
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The Potential Role of Integrin Signaling in Memory and Cognitive Impairment
Biomolecules, 2023 Dementia currently has no cure and, due to the increased prevalence and associated economic and personal burden of this condition, current research efforts for the development of potential therapies have intensified.
Ifechukwude Joachim Biose +4 more
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The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand
Life Science Alliance, 2023 The lectin domain of CD62P specifically binds to and activates integrins. CD62P-integrin interactions may function in a diverse set of cell–cell adhesions given that integrins are widely expressed.
Yoko K Takada +2 more
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Integrins regulate stemness in solid tumor: an emerging therapeutic target
Journal of Hematology & Oncology, 2021 Integrins are the adhesion molecules and transmembrane receptors that consist of α and β subunits. After binding to extracellular matrix components, integrins trigger intracellular signaling and regulate a wide spectrum of cellular functions, including ...
Jiangling Xiong +7 more
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Journal of Cell Science, 2006 Cell adhesion, migration and the maintenance of cell polarity are all processes that depend on the correct targeting of integrins and the dynamic remodelling of integrin-containing adhesion sites. The importance of the endo/exocytic cycle of integrins as a key regulator of these functions is increasingly recognized.
Ivaska, Johanna, Pellinen, Teijo
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Roles of Integrins in Gastrointestinal Cancer Metastasis
Frontiers in Molecular Biosciences, 2021 Integrins are a large family of heterodimeric transmembrane receptors which mediate cell adhesion and transmit signals to the cell interior. The mechanistic roles of integrins have long been an enigma in cancer, given its complexity in regulating ...
Sicong Hou +4 more
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Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?
Frontiers in Cellular and Infection Microbiology, 2021 The RGD motif in the Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2) spike protein has been predicted to bind RGD-recognizing integrins. Recent studies have shown that the spike protein does, indeed, interact with αVβ3 and α5β1 integrins, both of which ...
Christopher A. Beaudoin +5 more
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Journal of Cell Science, 2009 A successful immune response depends on the capacity of immune cells to travel from one location in the body to another–these cells are rapid migrators, travelling at speeds of μm/minute. Their ability to penetrate into tissues and to make contacts with other cells depends chiefly on the β2 integrin known as LFA-1.
Rachel, Evans +6 more
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Role of integrins in wound repair and its periodontal implications
Journal of Oral Biology and Craniofacial Research, 2018 Wound healing in human periodontium is a complex process which involves both cell-cell and cell-matrix interactions. Integrins play a major role in regulation of these cell-cell, cell-matrix interaction. Wound healing involves two major events i.e.
Harpal Jakhu +2 more
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