Results 11 to 20 of about 100,377 (261)
The Activation and Regulation of β2 Integrins in Phagocytes and Phagocytosis
Frontiers in Immunology, 2021 Phagocytes, which include neutrophils, monocytes, macrophages, and dendritic cells, protect the body by removing foreign particles, bacteria, and dead or dying cells.
Hao Sun +3 more
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Journal of Cell Science, 2006 Cell adhesion, migration and the maintenance of cell polarity are all processes that depend on the correct targeting of integrins and the dynamic remodelling of integrin-containing adhesion sites. The importance of the endo/exocytic cycle of integrins as a key regulator of these functions is increasingly recognized.
Ivaska, Johanna, Pellinen, Teijo
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The relative importance of platelet integrins in hemostasis, thrombosis and beyond
Haematologica, 2023 Integrins are heterodimeric transmembrane receptors composed of α and β chains, with an N-terminal extracellular domain forming a globular head corresponding to the ligand binding site.
Emily Janus-Bell, Pierre H. Mangin
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The Potential Role of Integrin Signaling in Memory and Cognitive Impairment
Biomolecules, 2023 Dementia currently has no cure and, due to the increased prevalence and associated economic and personal burden of this condition, current research efforts for the development of potential therapies have intensified.
Ifechukwude Joachim Biose +4 more
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The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand
Life Science Alliance, 2023 The lectin domain of CD62P specifically binds to and activates integrins. CD62P-integrin interactions may function in a diverse set of cell–cell adhesions given that integrins are widely expressed.
Yoko K Takada +2 more
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Integrins regulate stemness in solid tumor: an emerging therapeutic target
Journal of Hematology & Oncology, 2021 Integrins are the adhesion molecules and transmembrane receptors that consist of α and β subunits. After binding to extracellular matrix components, integrins trigger intracellular signaling and regulate a wide spectrum of cellular functions, including ...
Jiangling Xiong +7 more
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Roles of Integrins in Gastrointestinal Cancer Metastasis
Frontiers in Molecular Biosciences, 2021 Integrins are a large family of heterodimeric transmembrane receptors which mediate cell adhesion and transmit signals to the cell interior. The mechanistic roles of integrins have long been an enigma in cancer, given its complexity in regulating ...
Sicong Hou +4 more
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Genome Biology, 2007 The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane alphabeta heterodimers and at least 18 alpha and eight beta subunits are known in humans, generating 24 heterodimers.
Takada, Yoshikazu +2 more
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Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?
Frontiers in Cellular and Infection Microbiology, 2021 The RGD motif in the Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2) spike protein has been predicted to bind RGD-recognizing integrins. Recent studies have shown that the spike protein does, indeed, interact with αVβ3 and α5β1 integrins, both of which ...
Christopher A. Beaudoin +5 more
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Biochemical Society Transactions, 2008 Agonist stimulation of integrin receptors, composed of transmembrane α and β subunits, leads cells to regulate integrin affinity (‘activation’), a process that controls cell adhesion and migration, and extracellular matrix assembly. A final step in integrin activation is the binding of talin to integrin β cytoplasmic domains.
Asoka, Banno, Mark H, Ginsberg
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