Results 31 to 40 of about 105,036 (265)

SARS-CoV-2 Spike Protein Unlikely to Bind to Integrins via the Arg-Gly-Asp (RGD) Motif of the Receptor Binding Domain: Evidence From Structural Analysis and Microscale Accelerated Molecular Dynamics

Frontiers in Molecular Biosciences, 2022
The Receptor Binding Domain (RBD) of SARS-CoV-2 virus harbors a sequence of Arg-Gly-Asp tripeptide named RGD motif, which has also been identified in extracellular matrix proteins that bind integrins as well as other disintegrins and viruses. Accordingly,
Houcemeddine Othman, Houcemeddine Othman, Haifa Ben Messaoud, Oussema Khamessi, Hazem Ben-Mabrouk, Kais Ghedira, Avani Bharuthram, Florette Treurnicht, Ikechukwu Achilonu, Yasien Sayed, Najet Srairi-Abid   +10 more
doaj   +1 more source

β1 integrins as therapeutic targets to disrupt hallmarks of cancer

Frontiers in Pharmacology, 2015
Integrins belong to a large family of αβ heterodimeric transmembrane proteins first recognized as adhesion molecules that bind to dedicated elements of the extracellular matrix and also to other surrounding cells.
Anne-Florence eBlandin, Guillaume eRenner, Isabelle eLelong-Rebel, Sophie eMartin, Maxime eLehmann, Monique eDontenwill   +5 more
doaj   +1 more source

Integrins and the Myocardium [PDF]

Circulation Research, 2001
Abstract —Extracellular matrix provides a structural, chemical, and mechanical substrate that is essential in cardiac development, growth, and responses to pathophysiological signals. Transmembrane receptors termed integrins provide a dynamic interaction of environmental cues and intracellular events.
R S, Ross, T K, Borg
openaire   +2 more sources

Selectins and chemokines use shared and distinct signals to activate β2 integrins in neutrophils

Blood Advances, 2018
: Rolling neutrophils receive signals while engaging P- and E-selectin and chemokines on inflamed endothelium. Selectin signaling activates β2 integrins to slow rolling velocities. Chemokine signaling activates β2 integrins to cause arrest.
Tadayuki Yago, Nan Zhang, Liang Zhao, Charles S. Abrams, Rodger P. McEver   +4 more
doaj   +1 more source

The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells

Frontiers in Cell and Developmental Biology, 2022
Integrins regulate the adhesion and migration of blood cells to ensure the proper positioning of these cells in the environment. Integrins detect physical and chemical stimuli in the extracellular matrix and regulate signaling pathways in blood cells ...
Hao Sun, Frederic Lagarrigue, Mark H. Ginsberg   +2 more
doaj   +1 more source

Integrins and metastasis [PDF]

Cell Adhesion & Migration, 2013
Metastasis is a combination of biological events that makes the difference between cancer and other diseases. Metastasis requires flow of erroneous but precisely coordinated basic cellular activities like cell migration-invasion, cell survival-apoptosis, cell proliferation, etc. All of these processes require efficient regulation of cell attachment and
Kirat Kumar, Ganguly, Sekhar, Pal, Shuvojit, Moulik, Amitava, Chatterjee   +3 more
openaire   +2 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins

Frontiers in Neuroscience, 2019
Ischemic stroke is a leading cause of death and disability with limited therapeutic options. Resulting inflammatory mechanisms after reperfusion (removal of the thrombus) result in cytokine activation, calcium influx, and leukocytic infiltration to the ...
Danielle N. Edwards, Danielle N. Edwards, Gregory J. Bix, Gregory J. Bix   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike Protein

Viruses, 2021
Although ACE2 (angiotensin converting enzyme 2) is considered the primary receptor for CoV-2 cell entry, recent reports suggest that alternative pathways may contribute. This paper considers the hypothesis that viral binding to cell-surface integrins may
Lee Makowski, William Olson-Sidford, John W. Weisel   +2 more
doaj   +1 more source