Results 31 to 40 of about 100,377 (261)

The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells

Frontiers in Cell and Developmental Biology, 2022
Integrins regulate the adhesion and migration of blood cells to ensure the proper positioning of these cells in the environment. Integrins detect physical and chemical stimuli in the extracellular matrix and regulate signaling pathways in blood cells ...
Hao Sun, Frederic Lagarrigue, Mark H. Ginsberg   +2 more
doaj   +1 more source

SARS-CoV-2 Spike Protein Unlikely to Bind to Integrins via the Arg-Gly-Asp (RGD) Motif of the Receptor Binding Domain: Evidence From Structural Analysis and Microscale Accelerated Molecular Dynamics

Frontiers in Molecular Biosciences, 2022
The Receptor Binding Domain (RBD) of SARS-CoV-2 virus harbors a sequence of Arg-Gly-Asp tripeptide named RGD motif, which has also been identified in extracellular matrix proteins that bind integrins as well as other disintegrins and viruses. Accordingly,
Houcemeddine Othman, Houcemeddine Othman, Haifa Ben Messaoud, Oussema Khamessi, Hazem Ben-Mabrouk, Kais Ghedira, Avani Bharuthram, Florette Treurnicht, Ikechukwu Achilonu, Yasien Sayed, Najet Srairi-Abid   +10 more
doaj   +1 more source

β1 integrins as therapeutic targets to disrupt hallmarks of cancer

Frontiers in Pharmacology, 2015
Integrins belong to a large family of αβ heterodimeric transmembrane proteins first recognized as adhesion molecules that bind to dedicated elements of the extracellular matrix and also to other surrounding cells.
Anne-Florence eBlandin, Guillaume eRenner, Isabelle eLelong-Rebel, Sophie eMartin, Maxime eLehmann, Monique eDontenwill   +5 more
doaj   +1 more source

In mitosis integrins reduce adhesion to extracellular matrix and strengthen adhesion to adjacent cells

Nature Communications, 2023
To enter mitosis, most adherent animal cells reduce adhesion, which is followed by cell rounding. How mitotic cells regulate adhesion to neighboring cells and extracellular matrix (ECM) proteins is poorly understood.
Maximilian Huber, Javier Casares-Arias, Reinhard Fässler, Daniel J. Müller, Nico Strohmeyer   +4 more
doaj   +1 more source

Integral Roles for Integrins in γδ T Cell Function

Frontiers in Immunology, 2018
Integrins are adhesion receptors on the cell surface that enable cells to respond to their environment. Most integrins are heterodimers, comprising α and β type I transmembrane glycoprotein chains with large extracellular domains and short cytoplasmic ...
Gabrielle M. Siegers
doaj   +1 more source

The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins

Frontiers in Neuroscience, 2019
Ischemic stroke is a leading cause of death and disability with limited therapeutic options. Resulting inflammatory mechanisms after reperfusion (removal of the thrombus) result in cytokine activation, calcium influx, and leukocytic infiltration to the ...
Danielle N. Edwards, Danielle N. Edwards, Gregory J. Bix, Gregory J. Bix   +3 more
doaj   +1 more source

Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike Protein

Viruses, 2021
Although ACE2 (angiotensin converting enzyme 2) is considered the primary receptor for CoV-2 cell entry, recent reports suggest that alternative pathways may contribute. This paper considers the hypothesis that viral binding to cell-surface integrins may
Lee Makowski, William Olson-Sidford, John W. Weisel   +2 more
doaj   +1 more source

Integrin activation [PDF]

Journal of Cell Science, 2004
The ability of cells to regulate dynamically their adhesion to one another and to the extracellular matrix (ECM) that surrounds them is essential in multicellular organisms. The integrin family of transmembrane adhesion receptors mediates both cell-cell and cell-ECM adhesion.
openaire   +2 more sources

Selectins and chemokines use shared and distinct signals to activate β2 integrins in neutrophils

Blood Advances, 2018
: Rolling neutrophils receive signals while engaging P- and E-selectin and chemokines on inflamed endothelium. Selectin signaling activates β2 integrins to slow rolling velocities. Chemokine signaling activates β2 integrins to cause arrest.
Tadayuki Yago, Nan Zhang, Liang Zhao, Charles S. Abrams, Rodger P. McEver   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source