Results 31 to 40 of about 101,656 (264)
Nascent Adhesion Clustering: Integrin-Integrin and Integrin-Substrate Interactions [PDF]
Biophysica, 2022 Nascent adhesions (NAs) are a general precursor to the formation of focal adhesions (FAs) that provide a fundamental mechanism for cell adhesion that is, in turn, involved in cell proliferation, migration, and mechanotransduction. Nascent adhesions form when cells come into contact with substrates at all rigidities and generally involve the clustering ...
Kuanpo Lin, Robert J. Asaro
openaire +2 more sources
β1 integrins as therapeutic targets to disrupt hallmarks of cancer
Frontiers in Pharmacology, 2015 Integrins belong to a large family of αβ heterodimeric transmembrane proteins first recognized as adhesion molecules that bind to dedicated elements of the extracellular matrix and also to other surrounding cells.
Anne-Florence eBlandin +5 more
doaj +1 more source
The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells
Frontiers in Cell and Developmental Biology, 2022 Integrins regulate the adhesion and migration of blood cells to ensure the proper positioning of these cells in the environment. Integrins detect physical and chemical stimuli in the extracellular matrix and regulate signaling pathways in blood cells ...
Hao Sun +2 more
doaj +1 more source
Nature Communications, 2023 To enter mitosis, most adherent animal cells reduce adhesion, which is followed by cell rounding. How mitotic cells regulate adhesion to neighboring cells and extracellular matrix (ECM) proteins is poorly understood.
Maximilian Huber +4 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 The Receptor Binding Domain (RBD) of SARS-CoV-2 virus harbors a sequence of Arg-Gly-Asp tripeptide named RGD motif, which has also been identified in extracellular matrix proteins that bind integrins as well as other disintegrins and viruses. Accordingly,
Houcemeddine Othman +10 more
doaj +1 more source
The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins
Frontiers in Neuroscience, 2019 Ischemic stroke is a leading cause of death and disability with limited therapeutic options. Resulting inflammatory mechanisms after reperfusion (removal of the thrombus) result in cytokine activation, calcium influx, and leukocytic infiltration to the ...
Danielle N. Edwards +3 more
doaj +1 more source
Integral Roles for Integrins in γδ T Cell Function
Frontiers in Immunology, 2018 Integrins are adhesion receptors on the cell surface that enable cells to respond to their environment. Most integrins are heterodimers, comprising α and β type I transmembrane glycoprotein chains with large extracellular domains and short cytoplasmic ...
Gabrielle M. Siegers
doaj +1 more source
Viruses, 2021 Although ACE2 (angiotensin converting enzyme 2) is considered the primary receptor for CoV-2 cell entry, recent reports suggest that alternative pathways may contribute. This paper considers the hypothesis that viral binding to cell-surface integrins may
Lee Makowski +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Selectins and chemokines use shared and distinct signals to activate β2 integrins in neutrophils
Blood Advances, 2018 : Rolling neutrophils receive signals while engaging P- and E-selectin and chemokines on inflamed endothelium. Selectin signaling activates β2 integrins to slow rolling velocities. Chemokine signaling activates β2 integrins to cause arrest.
Tadayuki Yago +4 more
doaj +1 more source