Results 61 to 70 of about 386,087 (253)

FCHo2, not talin, enables inside-out activation of integrin ɑvβ5 in curved adhesions

Nature Communications
Extensive studies have shown that talin is the essential player for inside-out activation of integrins by binding to the intracellular tail of β integrins.
Chih-Hao Lu, Christina E. Lee, Wei Zhang, Yang Yang, Luis A. Valencia, He You, Ching-Ting Tsai, Bianxiao Cui   +7 more
doaj   +1 more source

Association between tensin 1 and p130Cas at focal adhesions links actin inward flux to cell migration

Biology Open, 2016
Cell migration is a highly dynamic process that plays pivotal roles in both physiological and pathological processes. We have previously reported that p130Cas supports cell migration through the binding to Src as well as phosphorylation-dependent ...
Zhihai Zhao, Song Hui Tan, Hiroaki Machiyama, Keiko Kawauchi, Keigo Araki, Hiroaki Hirata, Yasuhiro Sawada   +6 more
doaj   +1 more source

Contribution of the LIM domain and nebulin-repeats to the interaction of Lasp-2 with actin filaments and focal adhesions. [PDF]

PLoS ONE, 2009
Lasp-2 binds to actin filaments and concentrates in the actin bundles of filopodia and lamellipodia in neural cells and focal adhesions in fibroblastic cells.
Hiroyuki Nakagawa, Hiroshi Suzuki, Satoshi Machida, Junko Suzuki, Kazuyo Ohashi, Mingyue Jin, Shigeaki Miyamoto, Asako G Terasaki   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Mechanisms of Focal Adhesions [PDF]

, 2018
Focal adhesions are dynamic multiprotein structures connecting cells to their surrounding microenvironment. Cells receive critical mechanical signals from adhesions that control many cellular processes including wound healing, differentiation ...
Saxena, Mayur
core   +1 more source

Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions

eLife, 2016
The cross-talk between dynamic microtubules and integrin-based adhesions to the extracellular matrix plays a crucial role in cell polarity and migration.
Benjamin P Bouchet, Rosemarie E Gough, York-Christoph Ammon, Dieudonnée van de Willige, Harm Post, Guillaume Jacquemet, AF Maarten Altelaar, Albert JR Heck, Benjamin T Goult, Anna Akhmanova   +9 more
doaj   +1 more source

MAGI1 localizes to mature focal adhesion and modulates endothelial cell adhesion, migration and angiogenesis

Cell Adhesion & Migration, 2021
MAGI1 is an intracellular adaptor protein that stabilizes cell junctions and regulates epithelial and endothelial integrity. Here, we report that that in endothelial cells MAGI1 colocalizes with paxillin, β3-integrin, talin 1, tensin 3 and α-4-actinin at
Begoña Alday-Parejo, Kedar Ghimire, Oriana Coquoz, Gioele W. Albisetti, Luca Tamò, Jelena Zaric, Jimmy Stalin, Curzio Rüegg   +7 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Loss of the Essential Autophagy Regulators FIP200 or Atg5 Leads to Distinct Effects on Focal Adhesion Composition and Organization

Frontiers in Cell and Developmental Biology, 2020
Autophagy is an essential catabolic intracellular pathway that maintains homeostasis by degrading long-lived proteins, damaged organelles, and provides an energy source during nutrient starvation.
Emelia A. Assar, David A. Tumbarello
doaj   +1 more source