Journal of Biomedical Science, 2020 Background Among gynecological cancers, ovarian carcinoma has the highest mortality rate, and chemoresistance is highly prevalent in this cancer. Therefore, novel strategies are required to improve its poor prognosis.
Ho-Kai Huang +7 more
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The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions [PDF]
PeerJ, 2013 Loss of function mutations in the nuclear inner membrane protein, emerin, cause X-linked Emery-Dreifuss muscular dystrophy (X-EDMD). X-EDMD is characterized by contractures of major tendons, skeletal muscle weakening and wasting, and cardiac conduction ...
Michele A. Wozniak +3 more
doaj +2 more sources
Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity. [PDF]
, 2017 The vascular endothelium is subject to diverse mechanical cues that regulate vascular endothelial barrier function. In addition to rigidity sensing through integrin adhesions, mechanical perturbations such as changes in fluid shear stress can also ...
Andresen Eguiluz, Roberto C +3 more
core +1 more source
FCHo2, not talin, enables inside-out activation of integrin ɑvβ5 in curved adhesions
Nature CommunicationsExtensive studies have shown that talin is the essential player for inside-out activation of integrins by binding to the intracellular tail of β integrins.
Chih-Hao Lu +7 more
doaj +1 more source
Biology Open, 2016 Cell migration is a highly dynamic process that plays pivotal roles in both physiological and pathological processes. We have previously reported that p130Cas supports cell migration through the binding to Src as well as phosphorylation-dependent ...
Zhihai Zhao +6 more
doaj +1 more source
Contribution of the LIM domain and nebulin-repeats to the interaction of Lasp-2 with actin filaments and focal adhesions. [PDF]
PLoS ONE, 2009 Lasp-2 binds to actin filaments and concentrates in the actin bundles of filopodia and lamellipodia in neural cells and focal adhesions in fibroblastic cells.
Hiroyuki Nakagawa +7 more
doaj +1 more source
Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions [PDF]
, 2007 Focal adhesions attach cultured cells to the extracellular matrix, and we found endogenous protein phosphatase-1alpha isoform (PP1alpha) localized in adhesions across the entire area of adherent fibroblasts.
Brautigan, David L. +4 more
core +1 more source
Current approaches for modulation of the nanoscale interface in the regulation of cell behavior [PDF]
, 2018 Regulation of cell behavior in response to nanoscale features has been the focus of much research in recent years and the successful generation of nanoscale features capable of mimicking the natural nanoscale interface has been of great interest in the ...
Dalby, Matthew J. +3 more
core +1 more source
Focal Adhesion–Independent Cell Migration [PDF]
Annual Review of Cell and Developmental Biology, 2016 Cell migration is central to a multitude of physiological processes, including embryonic development, immune surveillance, and wound healing, and deregulated migration is key to cancer dissemination. Decades of investigations have uncovered many of the molecular and physical mechanisms underlying cell migration.
Ewa K. Paluch +2 more
openaire +4 more sources
Polarized focal adhesion kinase activity within a focal adhesion during cell migration
Nature Chemical Biology, 2023 Focal adhesion kinase (FAK) relays integrin signaling from outside to inside cells and contributes to cell adhesion and motility. However, the spatiotemporal dynamics of FAK activity in single FAs is unclear due to the lack of a robust FAK reporter, which limits our understanding of these essential biological processes.
Xiaoquan Li +3 more
openaire +4 more sources