Results 21 to 30 of about 823,784 (150)

Activation of Rho-kinase and focal adhesion kinase regulates the organization of stress fibers and focal adhesions in the central part of fibroblasts [PDF]

PeerJ, 2017
Specific regulation and activation of focal adhesion kinase (FAK) are thought to be important for focal adhesion formation, and activation of Rho-kinase has been suggested to play a role in determining the effects of FAK on the formation of stress fibers
Kazuo Katoh
doaj   +2 more sources

A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration [PDF]

, 2015
Fascin is an actin-binding and bundling protein that is highly upregulated in most epithelial cancers. Fascin promotes cell migration and adhesion dynamics in vitro and tumour cell metastasis in vivo.
Stramer, Brian M., Parsons, Maddy; id_orcid, Frame, Margaret, Bryan Serrels, Serrels, B, Parsons, M., Asier Jayo, Goult, B. T., Jayo, A., Zanet, J., Villari, G., Villari, G, Fitch, B., Serrels, Bryan, Stramer, BM, Fitch, Briana, Goult, Benjamin T., Frame, M., Jennifer Zanet, Frame, M, Jayo, Asier, Goult, Benjamin T, Goult, BT, Briana Fitch, Brian M. Stramer, Margaret Frame, Fitch, B, Stramer, B. M., Jayo, A, Zanet, Jennifer, Serrels, B., Maddy Parsons, Parsons, M, Giulia Villari, Zanet, J, Benjamin T. Goult, Villari, Giulia   +36 more
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The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells

eLife, 2016
Cell migration requires the cyclical assembly and disassembly of focal adhesions. Adhesion induces phosphorylation of focal adhesion proteins, including Cas (Crk-associated substrate/p130Cas/BCAR1).
Anjali Teckchandani, Jonathan A Cooper
doaj   +1 more source

FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells [PDF]

, 2011
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that is elevated in a variety of human cancers. While FAK is implicated in many cellular processes that are perturbed in cancer, including proliferation, actin and adhesion dynamics ...
Moran-Jones Kim, Moran-Jones, K., Graham Kathryn, Brunton Valerie G., Margaret C Frame, Owen J. Sansom, Frame, Margaret C., Moran-jones, Kim, Frame, M.C., Sansom, Owen J., Owen J Sansom, Brunton, V.G., Valerie G Brunton, Frame Margaret C., Valerie G. Brunton, Margaret C. Frame, Graham, K., Brunton, Valerie G., Kathryn Graham, Graham, Kathryn, Sansom Owen J., Sansom, O.J., Kim Moran-Jones   +22 more
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EVL is a novel focal adhesion protein involved in the regulation of cytoskeletal dynamics and vascular permeability

Pulmonary Circulation, 2021
Increases in lung vascular permeability is a cardinal feature of inflammatory disease and represents an imbalance in vascular contractile forces and barrier‐restorative forces, with both forces highly dependent upon the actin cytoskeleton.
Joseph B. Mascarenhas, Amir A. Gaber, Tania M. Larrinaga, Rachel Mayfield, Stefanie Novak, Sara M. Camp, Carol Gregorio, Jeffrey R. Jacobson, Anne E. Cress, Steven M. Dudek, Joe G.N. Garcia   +10 more
doaj   +1 more source

Profiling the responsiveness of focal adhesions of human cardiomyocytes to extracellular dynamic nano-topography

Bioactive Materials, 2022
Focal adhesion complexes function as the mediators of cell-extracellular matrix interactions to sense and transmit the extracellular signals. Previous studies have demonstrated that cardiomyocyte focal adhesions can be modulated by surface topographic ...
Huaiyu Shi, Xiangjun Wu, Shiyang Sun, Chenyan Wang, Zacharias Vangelatos, Ariel Ash-Shakoor, Costas P. Grigoropoulos, Patrick T. Mather, James H. Henderson, Zhen Ma   +9 more
doaj   +1 more source

αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells [PDF]

, 2013
The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM).
Muller, Daniel J, Myllymäki, Satu M., Jens Friedrichs, Aki Manninen (221960), Matlin, Karl S., Daniel J. Muller (2509858), Manninen, Aki, Myllymäki Satu M., Manninen Aki, Jose V Moyano, Strohmeyer, Nico; id_orcid, Teräväinen, Terhi P, Muller Daniel J., Terhi P. Teräväinen (447383), Jens Friedrichs (447385), Muller, Daniel J., Satu M Myllymäki, Engler, Adam J., Friedrichs Jens, Chuanyue Wu (196653), Satu M. Myllymäki (447384), Strohmeyer, Nico, Nico Strohmeyer (447386), Karl S. Matlin (447388), Moyano, Jose V, Teräväinen, Terhi P., Terhi P Teräväinen, Karl S Matlin, Chuanyue Wu, Wu, Chuanyue, Moyano, Jose V., Strohmeyer Nico, Myllymäki, Satu M, Aki Manninen, Daniel J Muller, Jose V. Moyano (447387), Matlin Karl S., Wu Chuanyue, Moyano Jose V., Nico Strohmeyer, Matlin, Karl S, Friedrichs, Jens, Teräväinen Terhi P.   +42 more
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Costamere remodeling with muscle loading and unloading in healthy young men [PDF]

, 2013
Costameres are mechano-sensory sites of focal adhesion in the sarcolemma that provide a structural anchor for myofibrils. Their turnover is regulated by integrin-associated focal adhesion kinase (FAK).
Erskine, Robert M., Seynnes, Olivier R., Simunic, B, Narici, MV, Flück M., Pisot, R, Flück, M., Rittweger J., Rittweger, Joern, Flueck, M, Narici M. V., Narici, Marco, Narici, Marco V., Flück, Martin, Seynnes O. R., Erskine, Robert, Li R., Rittweger, Jörn, Rittweger, J, Pisot, Rado, Seynnes, Olivier R, Seynnes, OR, Pišot R., Seynnes, Olivier, Li, Ruowei, Erskine, Robert M, Narici, Marco V, Erskine, RM, Šimunič B., Narici, Marco Vincenzo, Simunic, Bostjan, Erskine R. M., Li, R   +32 more
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Diverse cell junctions with unique molecular composition in tissues of a sponge (Porifera)

EvoDevo, 2019
The integrity and organization of animal tissues depend upon specialized protein complexes that mediate adhesion between cells with each other (cadherin-based adherens junctions), and with the extracellular matrix (integrin-based focal adhesions ...
Jennyfer M. Mitchell, Scott A. Nichols
doaj   +1 more source

Epidermal Growth Factor Receptor substrate 8 (Eps8) controls Src/FAK-dependent phenotypes in squamous carcinoma cells [PDF]

, 2014
Eps8 is an actin regulatory scaffold protein increased in Squamous Cell Carcinoma (SCC) cells. It forms a complex with both Focal Adhesion Kinase (FAK) and c-Src in SCC cells derived from the DMBA/TPA model of skin carcinogenesis.
Schoenherr, Christina, Baillie, George S., Frame, Margaret, Heath, John K., Proby, Charlotte, Frame, Margaret C., Cunningham, Debbie L, Findlay, Jane E, Cunningham, Debbie L., Findlay, Jane E., Baillie, George S, Heath, John K, Serrels, Bryan, Frame, Margaret C   +13 more
core   +1 more source