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The Focal Adhesion Analysis Server: a web tool for analyzing focal adhesion dynamics [v1; ref status: indexed, http://f1000r.es/yc] [PDF]
F1000Research, 2013 The Focal Adhesion Analysis Server (FAAS) is a web-based implementation of a set of computer vision algorithms designed to quantify the behavior of focal adhesions in cells imaged in 2D cultures.
Matthew E Berginski, Shawn M Gomez
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A Layered View on Focal Adhesions [PDF]
Biology, 2021 The cytoskeleton provides structure to cells and supports intracellular transport. Actin fibres are crucial to both functions. Focal Adhesions (FAs) are large macromolecular multiprotein assemblies at the ends of specialised actin fibres linking these to the extracellular matrix.
Legerstee, Karin +1 more
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Focal adhesions in osteoneogenesis [PDF]
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 2010 As materials technology and the field of tissue engineering advance, the role of cellular adhesive mechanisms, in particular, interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device technology is to use the exquisite ability of biological systems to respond to the material ...
M J P, Biggs, M J, Dalby
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TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly [PDF]
Journal of Cell Science, 2014 Focal adhesions (FAs) are macromolecular complexes that connect the actin cytoskeleton to the extracellular matrix. Dynamic turnover of FAs is critical for cell migration. Paxillin is a multi-adaptor protein that plays an important role in regulating FA dynamics.
Pradeep D, Uchil +13 more
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Cell Adhesion & Migration, 2022 To investigate a novel function of Dipterocarpus tuberculatus on focal cell adhesion stimulation, alterations to the regulation of focal cell adhesion-related factors were analyzed in NHDF cells and a calvarial defect rat model after treatment with ...
Su Jin Lee +9 more
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Frontiers in Cell and Developmental Biology, 2021 Background: Focal adhesion, as the intermediary between tumor cells and extracellular matrix communication, plays a variety of roles in tumor invasion, migration, and drug resistance.
Deli Mao +18 more
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Frontiers in Cell and Developmental Biology, 2020 Autophagy is an essential catabolic intracellular pathway that maintains homeostasis by degrading long-lived proteins, damaged organelles, and provides an energy source during nutrient starvation.
Emelia A. Assar, David A. Tumbarello
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Circulation Research, 2006 The vascular wall contains intimal endothelium and medial smooth muscle that act as contiguous tissues with tight spatial and functional coordination in response to tonic and episodic input from the bloodstream and the surrounding parenchyma. Focal adhesions are molecular bridges between the intracellular and extracellular spaces that integrate a ...
Lewis H, Romer +2 more
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mBio, 2021 Campylobacter jejuni is a major foodborne pathogen that exploits the focal adhesions of intestinal cells to promote invasion and cause severe gastritis.
Courtney M. Klappenbach +4 more
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Cas phosphorylation regulates focal adhesion assembly
eLife, 2023 Integrin-mediated cell attachment rapidly induces tyrosine kinase signaling. Despite years of research, the role of this signaling in integrin activation and focal adhesion assembly is unclear.
Saurav Kumar +4 more
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