Results 11 to 20 of about 823,784 (150)

Flotillins Regulate Focal Adhesions by Interacting with α-Actinin and by Influencing the Activation of Focal Adhesion Kinase

open access: yesCells, 2018
Cell–matrix adhesion and cell migration are physiologically important processes that also play a major role in cancer spreading. In cultured cells, matrix adhesion depends on integrin-containing contacts such as focal adhesions. Flotillin-1 and flotillin-
Antje Banning   +5 more
doaj   +2 more sources

Cas phosphorylation regulates focal adhesion assembly

open access: yeseLife, 2023
Integrin-mediated cell attachment rapidly induces tyrosine kinase signaling. Despite years of research, the role of this signaling in integrin activation and focal adhesion assembly is unclear.
Saurav Kumar   +4 more
doaj   +2 more sources

Nestin Modulates Airway Smooth Muscle Cell Migration by Affecting Spatial Rearrangement of Vimentin Network and Focal Adhesion Assembly

open access: yesCells, 2022
Airway smooth muscle cell migration plays a role in the progression of airway remodeling, a hallmark of allergic asthma. However, the mechanisms that regulate cell migration are not yet entirely understood.
Ruping Wang   +4 more
doaj   +2 more sources

PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility

open access: yesCells, 2020
Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associated with poor prognosis of cancer patients.
Hsin-Wei Jen   +3 more
doaj   +2 more sources

Loss of the Essential Autophagy Regulators FIP200 or Atg5 Leads to Distinct Effects on Focal Adhesion Composition and Organization

open access: yesFrontiers in Cell and Developmental Biology, 2020
Autophagy is an essential catabolic intracellular pathway that maintains homeostasis by degrading long-lived proteins, damaged organelles, and provides an energy source during nutrient starvation.
Emelia A. Assar, David A. Tumbarello
doaj   +1 more source

Campylobacter jejuni Triggers Signaling through Host Cell Focal Adhesions To Inhibit Cell Motility

open access: yesmBio, 2021
Campylobacter jejuni is a major foodborne pathogen that exploits the focal adhesions of intestinal cells to promote invasion and cause severe gastritis.
Courtney M. Klappenbach   +4 more
doaj   +1 more source

Modelling stromal FAK regulation of tumour growth, angiogenesis and progression [PDF]

open access: yes, 2012
PhDThe growth of tumours within a whole organism depends on the tumour microenvironment. This involves both resident stromal cells, such as endothelial cells and fibroblasts, and also bone marrow derived stromal cells.
Batista, Silvia
core   +4 more sources

Myosin II-mediated focal adhesion maturation is tension insensitive.

open access: yesPLoS ONE, 2013
Myosin II motors drive changes in focal adhesion morphology and composition in a "maturation process" that is crucial for regulating adhesion dynamics and signaling guiding cell adhesion, migration and fate.
Jonathan Stricker   +3 more
doaj   +1 more source

Guiding cell adhesion and motility by modulating cross-linking and topographic properties of microgel arrays.

open access: yesPLoS ONE, 2021
Biomaterial-driven modulation of cell adhesion and migration is a challenging aspect of tissue engineering. Here, we investigated the impact of surface-bound microgel arrays with variable geometry and adjustable cross-linking properties on cell adhesion ...
Janine Riegert   +11 more
doaj   +1 more source

Multi-omics analysis reveals focal adhesion characteristic associated tumor immune microenvironment in colon adenocarcinoma

open access: yesFrontiers in Genetics, 2023
Colon adenocarcinoma (COAD) is one of the most frequent malignant lesions of the digestive system in humans, with an insidious onset. At the time of diagnosis, most of them have developed to the middle and late stages, and cancer cells have metastasized,
Xiaoming Xu, Jingzhi Wang
doaj   +1 more source

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