Results 11 to 20 of about 150,148 (211)

Cross-Talk of Focal Adhesion-Related Gene Defines Prognosis and the Immune Microenvironment in Gastric Cancer

Frontiers in Cell and Developmental Biology, 2021
Background: Focal adhesion, as the intermediary between tumor cells and extracellular matrix communication, plays a variety of roles in tumor invasion, migration, and drug resistance.
Deli Mao, Deli Mao, Deli Mao, Rui Xu, Rui Xu, Rui Xu, Hengxing Chen, Hengxing Chen, Xiancong Chen, Xiancong Chen, Dongsheng Li, Dongsheng Li, Shenglei Song, Shenglei Song, Yulong He, Yulong He, Zhewei Wei, Changhua Zhang, Changhua Zhang   +18 more
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Novel role of Dipterocarpus tuberculatus as a stimulator of focal cell adhesion through the regulation of MLC2/FAK/Akt signaling pathway

Cell Adhesion & Migration, 2022
To investigate a novel function of Dipterocarpus tuberculatus on focal cell adhesion stimulation, alterations to the regulation of focal cell adhesion-related factors were analyzed in NHDF cells and a calvarial defect rat model after treatment with ...
Su Jin Lee, Ji Eun Kim, Jae Won Jung, Yun Ju Choi, Jeong Eun Gong, Bounleuane Douangdeuane, Onevilay Souliya, Young Whan Choi, Sung Baek Seo, Dae Youn Hwang   +9 more
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Loss of the Essential Autophagy Regulators FIP200 or Atg5 Leads to Distinct Effects on Focal Adhesion Composition and Organization

Frontiers in Cell and Developmental Biology, 2020
Autophagy is an essential catabolic intracellular pathway that maintains homeostasis by degrading long-lived proteins, damaged organelles, and provides an energy source during nutrient starvation.
Emelia A. Assar, David A. Tumbarello
doaj   +1 more source

Campylobacter jejuni Triggers Signaling through Host Cell Focal Adhesions To Inhibit Cell Motility

mBio, 2021
Campylobacter jejuni is a major foodborne pathogen that exploits the focal adhesions of intestinal cells to promote invasion and cause severe gastritis.
Courtney M. Klappenbach, Nicholas M. Negretti, Jesse Aaron, Teng-Leong Chew, Michael E. Konkel   +4 more
doaj   +1 more source

Cas phosphorylation regulates focal adhesion assembly

eLife, 2023
Integrin-mediated cell attachment rapidly induces tyrosine kinase signaling. Despite years of research, the role of this signaling in integrin activation and focal adhesion assembly is unclear.
Saurav Kumar, Amanda Stainer, Julien Dubrulle, Christopher Simpkins, Jonathan A Cooper   +4 more
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Myosin II-mediated focal adhesion maturation is tension insensitive.

PLoS ONE, 2013
Myosin II motors drive changes in focal adhesion morphology and composition in a "maturation process" that is crucial for regulating adhesion dynamics and signaling guiding cell adhesion, migration and fate.
Jonathan Stricker, Yvonne Beckham, Michael W Davidson, Margaret L Gardel   +3 more
doaj   +1 more source

Guiding cell adhesion and motility by modulating cross-linking and topographic properties of microgel arrays.

PLoS ONE, 2021
Biomaterial-driven modulation of cell adhesion and migration is a challenging aspect of tissue engineering. Here, we investigated the impact of surface-bound microgel arrays with variable geometry and adjustable cross-linking properties on cell adhesion ...
Janine Riegert, Alexander Töpel, Jana Schieren, Renee Coryn, Stella Dibenedetto, Dominik Braunmiller, Kamil Zajt, Carmen Schalla, Stephan Rütten, Martin Zenke, Andrij Pich, Antonio Sechi   +11 more
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EVL is a novel focal adhesion protein involved in the regulation of cytoskeletal dynamics and vascular permeability

Pulmonary Circulation, 2021
Increases in lung vascular permeability is a cardinal feature of inflammatory disease and represents an imbalance in vascular contractile forces and barrier‐restorative forces, with both forces highly dependent upon the actin cytoskeleton.
Joseph B. Mascarenhas, Amir A. Gaber, Tania M. Larrinaga, Rachel Mayfield, Stefanie Novak, Sara M. Camp, Carol Gregorio, Jeffrey R. Jacobson, Anne E. Cress, Steven M. Dudek, Joe G.N. Garcia   +10 more
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Multi-omics analysis reveals focal adhesion characteristic associated tumor immune microenvironment in colon adenocarcinoma

Frontiers in Genetics, 2023
Colon adenocarcinoma (COAD) is one of the most frequent malignant lesions of the digestive system in humans, with an insidious onset. At the time of diagnosis, most of them have developed to the middle and late stages, and cancer cells have metastasized,
Xiaoming Xu, Jingzhi Wang
doaj   +1 more source

The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells

eLife, 2016
Cell migration requires the cyclical assembly and disassembly of focal adhesions. Adhesion induces phosphorylation of focal adhesion proteins, including Cas (Crk-associated substrate/p130Cas/BCAR1).
Anjali Teckchandani, Jonathan A Cooper
doaj   +1 more source