Results 31 to 40 of about 146,956 (260)
Haematologica, 2018 Mantle cell lymphoma and other lymphoma subtypes often spread to the bone marrow, and stromal interactions mediated by focal adhesion kinase frequently enhance survival and drug resistance of the lymphoma cells. To study the role of focal adhesion kinase
Martina Rudelius +7 more
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PLoS ONE, 2012 The speed of cell migration on 2-dimensional (2D) surfaces is determined by the rate of assembly and disassembly of clustered integrin receptors known as focal adhesions.
Jessie Zhong +7 more
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Differential regulation of adhesion complex turnover by ROCK1 and ROCK2. [PDF]
PLoS ONE, 2012 ROCK1 and ROCK2 are serine/threonine kinases that function downstream of the small GTP-binding protein RhoA. Rho signalling via ROCK regulates a number of cellular functions including organisation of the actin cytoskeleton, cell adhesion and cell ...
Frances E Lock +4 more
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FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
Annual Review of Cell and Developmental Biology, 1996 ▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provide a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control.
K, Burridge, M, Chrzanowska-Wodnicka
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Biology Open, 2016 Several focal adhesion proteins are known to cooperate with integrins to link the extracellular matrix to the actin cytoskeleton; as a result, many intracellular signaling pathways are activated and several focal adhesion complexes are formed.
Ana L. Roa-Espitia +7 more
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Wound-induced polyploidization is dependent on Integrin-Yki signaling
Biology Open, 2021 A key step in tissue repair is to replace lost or damaged cells. This occurs via two strategies: restoring cell number through proliferation or increasing cell size through polyploidization.
Rose Besen-McNally +2 more
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Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration [PDF]
Scientific Reports, 2015 AbstractDirected cell migration requires dynamical control of the protein complex within focal adhesions (FAs) and this control is regulated by signaling events involving tyrosine phosphorylation. We screened the SH2 domains present in tyrosine-specific kinases and phosphatases found within FAs, including SRC, SHP1 and SHP2 and examined whether these ...
Jui-Chung Wu +6 more
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Focal adhesions are controlled by microtubules through local contractility regulation
The EMBO JournalMicrotubules regulate cell polarity and migration via local activation of focal adhesion turnover, but the mechanism of this process is insufficiently understood.
Julien Aureille +9 more
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Frontiers in Cell and Developmental Biology, 2022 Cell-substrate adhesion is a critical aspect of many forms of cell migration. Cell adhesion to an extracellular matrix (ECM) generates traction forces necessary for efficient migration.
Julio C. Fierro Morales +2 more
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Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover
Journal of Cell Science, 2000 ABSTRACT Focal adhesion kinase (FAK) is activated and localized at focal adhesions upon cell adhesion to extracellular matrices. Cells lacking FAK show increased focal adhesion number and decreased cell migration, functions that are regulated by the small GTPase Rho.
X D, Ren +5 more
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