Results 31 to 40 of about 823,784 (150)
Modulation of cell-matrix adhesions to affect mechanotransduction [PDF]
, 2010 In cultured fibroblasts three types of cell-matrix adhesion with specific cellular localization and protein composition can be distinguished: focal complexes, focal adhesions and fibrillar adhesions.
Lutz, Roman
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F1000Research, 2013 The Focal Adhesion Analysis Server (FAAS) is a web-based implementation of a set of computer vision algorithms designed to quantify the behavior of focal adhesions in cells imaged in 2D cultures.
Matthew E Berginski, Shawn M Gomez
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Cell Death and Disease, 2023 Numerous studies have investigated the various cellular responses against genotoxic stress, including those mediated by focal adhesions. We here identified a novel type of focal adhesion remodelling that occurs under genotoxic stress conditions, which ...
Masatsune Tsujioka +8 more
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Haematologica, 2018 Mantle cell lymphoma and other lymphoma subtypes often spread to the bone marrow, and stromal interactions mediated by focal adhesion kinase frequently enhance survival and drug resistance of the lymphoma cells. To study the role of focal adhesion kinase
Martina Rudelius +7 more
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PLoS ONE, 2012 The speed of cell migration on 2-dimensional (2D) surfaces is determined by the rate of assembly and disassembly of clustered integrin receptors known as focal adhesions.
Jessie Zhong +7 more
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ADAM15 modulates outside-in signalling in chondrocyte–matrix interactions [PDF]
, 2008 ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions.
Böhm, Beate B. +5 more
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Differential regulation of adhesion complex turnover by ROCK1 and ROCK2. [PDF]
PLoS ONE, 2012 ROCK1 and ROCK2 are serine/threonine kinases that function downstream of the small GTP-binding protein RhoA. Rho signalling via ROCK regulates a number of cellular functions including organisation of the actin cytoskeleton, cell adhesion and cell ...
Frances E Lock +4 more
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Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation [PDF]
, 2014 The force-dependent interaction between talin and vinculin plays a crucial role in the initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the mechano-sensitive compact N-terminal region of the talin rod, and show that
J. Yan (3377042) +26 more
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, 2023 Focal adhesions are critical to cell motility, morphology, and neuronal circuit formation. Proper neuronal circuit formation relies on neurons reaching the right location, assuming a specific morphology, and connecting with signaling partners. While much
Petritsch, Amanda Michelle +1 more
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Biology Open, 2016 Several focal adhesion proteins are known to cooperate with integrins to link the extracellular matrix to the actin cytoskeleton; as a result, many intracellular signaling pathways are activated and several focal adhesion complexes are formed.
Ana L. Roa-Espitia +7 more
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