Results 31 to 40 of about 150,148 (211)

Focal adhesions are controlled by microtubules through local contractility regulation

The EMBO Journal
Microtubules regulate cell polarity and migration via local activation of focal adhesion turnover, but the mechanism of this process is insufficiently understood.
Julien Aureille, Srinivas S Prabhu, Sam F Barnett, Aaron J Farrugia, Isabelle Arnal, Laurence Lafanechère, Boon Chuan Low, Pakorn Kanchanawong, Alex Mogilner, Alexander D Bershadsky   +9 more
doaj   +1 more source

An evolutionary and physiological perspective on cell-substrate adhesion machinery for cell migration

Frontiers in Cell and Developmental Biology, 2022
Cell-substrate adhesion is a critical aspect of many forms of cell migration. Cell adhesion to an extracellular matrix (ECM) generates traction forces necessary for efficient migration.
Julio C. Fierro Morales, Qian Xue, Minna Roh-Johnson   +2 more
doaj   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca2+ entry-mediated turnover of focal adhesions

Journal of Biomedical Science, 2020
Background Among gynecological cancers, ovarian carcinoma has the highest mortality rate, and chemoresistance is highly prevalent in this cancer. Therefore, novel strategies are required to improve its poor prognosis.
Ho-Kai Huang, Yi-Hsin Lin, Heng-Ai Chang, Yi-Shyun Lai, Ying-Chi Chen, Soon-Cen Huang, Cheng-Yang Chou, Wen-Tai Chiu   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Abnormal Endothelial Gene Expression Associated With Early Coronary Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background We examined feasibility of a unique approach towards gaining insight into heritable risk for early atherosclerosis: surveying gene expression by endothelial cells from living subjects. Methods and Results Subjects aged
Robert P. Hebbel, Peng Wei, Liming Milbauer, Michel T. Corban, Anna Solovey, James Kiley, Jack Pattee, Lilach O. Lerman, Wei Pan, Amir Lerman   +9 more
doaj   +1 more source

HAb18G/CD147 regulates vinculin-mediated focal adhesion and cytoskeleton organization in cultured human hepatocellular carcinoma cells. [PDF]

PLoS ONE, 2014
Focal adhesions (FAs), integrin-mediated macromolecular complexes located at the cell membrane extracellular interface, have been shown to regulate cell adhesion and migration.
Qiang Liang, Qing Han, Wan Huang, Gang Nan, Bao-Qing Xu, Jian-Li Jiang, Zhi-Nan Chen   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A celiac cellular phenotype, with altered LPP sub-cellular distribution, is inducible in controls by the toxic gliadin peptide P31-43. [PDF]

PLoS ONE, 2013
Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Undigested gliadin peptides P31-43 and P57-68 induce innate and adaptive T cell-mediated immune responses, respectively ...
Merlin Nanayakkara, Roberta Kosova, Giuliana Lania, Marco Sarno, Alessandra Gaito, Martina Galatola, Luigi Greco, Marialaura Cuomo, Riccardo Troncone, Salvatore Auricchio, Renata Auricchio, Maria Vittoria Barone   +11 more
doaj   +1 more source