Stabilizing to disruptive transition of focal adhesion response to mechanical forces
, 2010 Strong mechanical forces can, obviously, disrupt cell-cell and cell-matrix adhesions, e.g., cyclic uniaxial stretch induces instability of cell adhesion, which then causes the reorientation of cells away from the stretching direction.
孔冬, 戴兰宏, 季葆华
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Measuring cell adhesion forces with the atomic force microscope at the molecular level [PDF]
, 2002 In the past 25 years many techniques have been developed to characterize cell adhesion and to quantify adhesion forces. Atomic force microscopy (AFM) has been used to measure forces in the pico-newton range, an experimental technique known as force ...
Benoit, M., Gaub, H. E.
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Dissecting interactions within focal adhesions: studies on vinculin
, 2008 Vinculin and paxillin are proteins that localise to focal adhesions. Focal adhesions arespecialised sites of cell attachment between the cytoplasmic side of the cell membrane andthe extracellular matrix.
Cox, Clare Louise
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Characterization of tenascin-C-induced signaling in tumorigenesis [PDF]
, 2008 During cancer progression, the extracellular matrix (ECM) is extensively remodeled. The ECM molecule tenascin-C is an adhesion-modulating molecule, which is highly expressed in tumor stroma.
Lange, Katrin
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Growth-factor-induced, persistent fibroblast migration is mediated by mechanical insulation of cell front and back [PDF]
, 2014 Cell migration is a crucial process during development, the immune response and wound healing. As a consequence, aberrant cell migration can lead to tumor metastasis or autoimmune disorders.
Martin, Katrin
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Paxillin Binding Is Not the Sole Determinant of Focal Adhesion Localization or Dominant-Negative Activity of Focal Adhesion Kinase/Focal Adhesion Kinase-related Nonkinase [PDF]
, 2000 The carboxy-terminal 150 residues of the focal adhesion kinase (FAK) comprise the focal adhesion-targeting sequence, which is responsible for its subcellular localization. The mechanism of focal adhesion targeting has not been fully elucidated.
Schaller, M. D. +4 more
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Mechanotransduction in striated muscle via focal adhesion kinase [PDF]
, 2007 Contractile tissues demonstrate a pronounced capacity to remodel their composition in response to mechanical challenges. Descriptive evidence suggests the upstream involvement of the phosphotransfer enzyme FAK (focal adhesion kinase) in the molecular ...
M Flück +13 more
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Mechanism of Focal Adhesion Kinase Mechanosensing.
PLoS Computational Biology, 2015 Mechanosensing at focal adhesions regulates vital cellular processes. Here, we present results from molecular dynamics (MD) and mechano-biochemical network simulations that suggest a direct role of Focal Adhesion Kinase (FAK) as a mechano-sensor. Tensile
Jing Zhou +5 more
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Nanoimaging of focal adhesion dynamics in 3D. [PDF]
PLoS ONE, 2014 Organization and dynamics of focal adhesion proteins have been well characterized in cells grown on two-dimensional (2D) cell culture surfaces. However, much less is known about the dynamic association of these proteins in the 3D microenvironment ...
Chi-Li Chiu +5 more
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Solid Phase Peptide Synthesis: Analysis and Identification of Protein Kinase Substrates [PDF]
, 2005 This research study examines the synthesis of tyrosine containing peptides based on the protein paxillin. Paxillin is a proposed substrate of the Focal Adhesion Kinase (FAK) protein tyrosine kinase.
Kroodsma, Derrick
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