Results 71 to 80 of about 823,784 (150)

The effects of colloidal nanotopography on initial fibroblast adhesion and morphology [PDF]

, 2006
Colloidal lithography offers a simple, inexpensive method of producing irregular nanotopographies, a pattern not easily attainable utilizing conventional serial writing processes.
Wood, M.A., Curtis, A., Wilkinson, C.D.W.   +2 more
core   +1 more source

Role of the Ste20‐like kinase SLK in podocyte adhesion

Physiological Reports
SLK controls the cytoskeleton, cell adhesion, and migration. Podocyte‐specific deletion of SLK in mice leads to podocyte injury as mice age and exacerbates injury in experimental focal segment glomerulosclerosis (FSGS; adriamycin nephrosis).
Andrey V. Cybulsky, Joan Papillon, Craig Bryan, José R. Navarro‐Betancourt, Luc A. Sabourin   +4 more
doaj   +1 more source

Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer

Journal of Experimental & Clinical Cancer Research, 2018
Background Focal adhesion plays an essential role in tumour invasiveness and metastasis. Hippo component YAP has been widely reported to be involved in many aspects of tumour biology.
Jie Shen, Beibei Cao, Yatao Wang, Chenshen Ma, Zhuo Zeng, Liang Liu, Xiaolan Li, Deding Tao, Jianping Gong, Daxing Xie   +9 more
doaj   +1 more source

Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes [PDF]

, 2007
Adhesion molecules of the integrin beta1 family are thought to be involved in the malignant progression renal cell carcinoma (RCC). Still, it is not clear how they contribute to this process.
Jones, Jon, Jüngel, Eva, Dietger Jonas, Blaheta, Roman A., Roman A.Blaheta, Stefan Berkhoff, Tobias Engl, Wedel, Steffen Alexander, Jonas, Dietger, Berkhoff, Stefan, Jon Jones, Borna Relja, Relja, Borna, Eva Weich, Steffen Wedel, Engl, Tobias A.   +15 more
core   +1 more source

Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation

eLife
Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form LLPS, which govern adhesion dynamics and related cell
Abhishek Kumar, Keiichiro Tanaka, Martin A Schwartz   +2 more
doaj   +1 more source

A novel gene signature related to focal adhesions for distinguishing and predicting the prognosis of lung squamous cell carcinoma

Frontiers in Medicine
BackgroundLung squamous cell carcinoma (LUSC) is a devastating and difficult-to-treat type of lung cancer, and the prognosis of LUSC is the worst. The functional roles of focal adhesion-related genes were explored in LUSC based on data from The Cancer ...
Gang Hui, Yuancai Xie, Li Niu, Li Niu, Jixian Liu   +4 more
doaj   +1 more source

Focal Adhesion pathway.

, 2013
Kaplan-Meier disease-free survival estimates for high- and low-risk patients, as defined by the focal adhesion pathway genes (log-rank ...
Elena Fountzilas (250818), Elke Veltrup (443872), Angelos Nikolaou (276647), Dimitrios Pectasides (62261), Nikolaos Angouridakis (276645), Anastasia G. Eleftheraki (439178), George Fountzilas (8221), Vassiliki Kotoula (161014), Ilias Karasmanis (276643), Konstantinos Markou (276642), Ralph M. Wirtz (439180)   +10 more
core   +1 more source

Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling

, 2016
Metastasis is a complex process that is regulated by multiple signaling pathways, with the focal adhesion kinase (FAK)/paxillin pathway playing a major role in the formation of focal adhesions and cell motility.
Sahni, Sumit, Wangpu, Xiongzhi, Xi, Ruxing, Menezes, Sharleen, Huang, Michael LH, Kovacevic, Zaklina, Park, Kyung Chan, Lu, Jiaoyang, Yue, Fei, Richardson, Des R, Zheng, Minhua   +10 more
core   +1 more source

Mechanostimulation-Induced Cell Adhesion and Interaction with the Extracellular Matrix

Biomolecules
Cells sense and transmit mechanical forces exerted by their environment to the nucleus via adhesion sites and the cytoskeleton. The nucleus interprets these mechanical inputs and determines cell fate and behavior by regulating gene expression.
Kazuo Katoh
doaj   +1 more source

Talin1 Promotes Prostate Cancer Invasion and Metastasis via AKT Signaling and Anoikis Resistance [PDF]

, 2009
Talin1 is an integrin regulatory protein that mediates integrin interactions with the extracellular matrix (ECM). This study investigated the significance of talin1 in prostate cancer progression to metastasis in vitro and in vivo.
Natasha Kyprianou, Shinichi Sakamoto, Richard McCann   +2 more
core