Results 61 to 70 of about 823,784 (150)

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover [PDF]

, 2000
Focal adhesion kinase (FAK) is activated and localized at focal adhesions upon cell adhesion to extracellular matrices. Cells lacking FAK show increased focal adhesion number and decreased cell migration, functions that are regulated by the small GTPase ...

core   +1 more source

K⁺ Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and Spreading through Modulation of Ca²⁺ Signaling and Rac1 Activity

Cells, 2020
Cell migration is critical for several physiological and pathophysiological processes. It depends on the coordinated action of kinases, phosphatases, Rho-GTPases proteins, and Ca2+ signaling.
Jimena Canales, Pablo Cruz, Nicolás Díaz, Denise Riquelme, Elías Leiva-Salcedo, Oscar Cerda   +5 more
doaj   +1 more source

Frequency-Dependent Focal Adhesion Instability and Cell Reorientation Under Cyclic Substrate Stretching

, 2011
The adhesion-based cell mechanosensitivity plays central roles in many physiological and pathological processes. Recently, quantitative understanding of cell responses to external force has been intensively pursued.
孔冬, Ji, BH (reprint author), Beijing Inst Technol, Biomech & Biomat Lab, Dept Appl Mech, Beijing 100081, Peoples R China, 戴兰宏, Zhong Y, 季葆华   +4 more
core   +1 more source

Pulsed ultrasound promotes melanoblast migration through upregulation of macrophage colony-stimulating factor/focal adhesion kinase autocrine signaling and paracrine mechanisms

, 2017
Repigmentation of vitiliginous lesions relies on the proliferation and migration of melanoblasts from hair follicles to the epidermis. Pulsed ultrasound has been demonstrated to have stimulatory effects on cell proliferation and migration and has been ...
Liao, Yi-Hua;Huang, Yu-Ting;Deng, Jhu-Yun;Chen, Wen-Shiang;Jee, Shiou-Hwa, 陳文翔;紀秀華;廖怡華   +1 more
core   +1 more source

Hyaluronic acid and epidermal growth factor improved the bovine embryo quality by regulating the DNA methylation and expression patterns of the focal adhesion pathway.

PLoS ONE, 2019
Focal adhesion pathway is one of the key molecular pathways affected by suboptimal culture conditions during embryonic development. The epidermal growth factor (EGF) and hyaluronic acid (HA) are believed to be involved in the focal adhesion pathway ...
Mohammed Saeed-Zidane, Dawit Tesfaye, Yousri Mohammed Shaker, Ernst Tholen, Christiane Neuhoff, Franca Rings, Eva Held, Michael Hoelker, Karl Schellander, Dessie Salilew-Wondim   +9 more
doaj   +1 more source

FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions

Biomolecules, 2020
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the regulation of cell adhesion migration, proliferation and survival. In cancer FAK is a major driver of invasion and metastasis and its upregulation is associated with poor
Paula Tapial Martínez, Pilar López Navajas, Daniel Lietha   +2 more
doaj   +1 more source

Focal adhesion dynamics are altered in schizophrenia [PDF]

, 2013
Background: Evidence from genetic association studies implicate genes involved in neural migration associated with schizophrenia risk. Neural stem/progenitor cell cultures (neurosphere-derived cells) from olfactory mucosa of schizophrenia patients have ...
Cooper-White, Justin, Calderon, Claudia C., Abrahamsen, Greger, Fan, Yongjun, Tee, Jing Yang, Mackay-Sim, Alan, Murrell, Wayne, Leyton, Lisette, McGrath, John J., Tee, Bernard, Mills, Richard, Calderon, Claudia C, Leyton Campos, Lisette, Mackay Sim, Alan, McGrath, John J, Cooper White, Justin, C. Calderon, Claudia, J. McGrath, John   +17 more
core   +1 more source

Vimentin associated focal adhesion nanostructure characterization

, 2021
Focal adhesions are multiprotein structures that connect cells to the extracellular matrix. They serve as an anchorage site for the cytoskeletal network and play a significant role in mechanosensing and signal transduction, leading to change in cell ...
Aryal, Ujjwal
core   +1 more source

Bridging the gap

eLife, 2016
A new study reveals that a protein called talin forms a vital link between microtubules and focal adhesions at the surface of cells.
Sarah K Armitage, Sergey V Plotnikov
doaj   +1 more source

Plasma Proteins at the Interface of Dental Implants Modulate Osteoblasts Focal Adhesions Expression and Cytoskeleton Organization

Nanomaterials, 2019
The host-material interface is a crucial relationship dictating the possibility of successful osseointegration in implant dentistry. The aim of the present study was to characterize the effects of plasma proteins pre-adsorption on the adhesion capacity ...
Ludovica Parisi, Andrea Toffoli, Miriam Cutrera, Massimiliano G. Bianchi, Simone Lumetti, Ovidio Bussolati, Guido M. Macaluso   +6 more
doaj   +1 more source