Results 31 to 40 of about 24,624 (157)

Role of Mechanotransduction in Cellular Processes [PDF]

Biophysical Journal, 2009
The role of mechanical properties of cells is gaining increasing attention due to the regulatory role that it plays in cellular processes. In particular the transduction of an applied force on the cell membrane through the cellular components can have significant influence on such phenomena as stochasticity in gene expression and cancer metastasis.
Srividya, Narayanan, Balandaram, Gayathri, Bandaranayake, Chandima, Muralidharan, Subra   +3 more
openaire   +1 more source

3D Cell Culture for the Study of Microenvironment-Mediated Mechanostimuli to the Cell Nucleus: An Important Step for Cancer Research

Frontiers in Molecular Biosciences, 2021
The discovery that the stiffness of the tumor microenvironment (TME) changes during cancer progression motivated the development of cell culture involving extracellular mechanostimuli, with the intent of identifying mechanotransduction mechanisms that ...
Apekshya Chhetri, Apekshya Chhetri, Joseph V. Rispoli, Joseph V. Rispoli, Sophie A. Lelièvre, Sophie A. Lelièvre   +5 more
doaj   +1 more source

Traction Force Microscopy for Understanding Cellular Mechanotransduction

BMB Reports, 2020
Under physiological and pathological conditions, mechanical forces generated from cells themselves or transmitted from extracellular matrix (ECM) through focal adhesions (FAs) and adherens junctions (AJs) are known to play a significant role in regulating various cell behaviors.
Hur, Sung Sik, Jeong, Ji Hoon, Ban, Myung Jin, Park, Jae Hong, Yoon, Jeong Kyo, Hwang, Yongsung   +5 more
openaire   +3 more sources

Flow-dependent cellular mechanotransduction in atherosclerosis

Journal of Cell Science, 2013
Atherosclerosis depends on risk factors such as hyperlipidemia, smoking, hypertension and diabetes. Although these risk factors are relatively constant throughout the arterial circulation, atherosclerotic plaques occur at specific sites where flow patterns are disturbed, with lower overall magnitude and complex changes in speed and direction.
Daniel E, Conway, Martin A, Schwartz
openaire   +3 more sources

A trio of biological rhythms and their relevance in rhythmic mechanical stimulation of cell cultures

Frontiers in Psychology, 2022
The primary aim of this article is to provide a biological rhythm model based on previous theoretical and experimental findings to promote more comprehensive studies of rhythmic mechanical stimulation of cell cultures, which relates to tissue engineering
Dongho Kwak, Petter Angell Olsen, Petter Angell Olsen, Anne Danielsen, Alexander Refsum Jensenius   +4 more
doaj   +1 more source

Shc and the mechanotransduction of cellular anchorage and metastasis [PDF]

Small GTPases, 2017
Tissue cells continually monitor anchorage conditions by gauging the physical properties of their underlying matrix and surrounding environment. The Rho and Ras GTPases are essential components of these mechanosensory pathways. These molecular switches control both cytoskeletal as well as cell fate responses to anchorage conditions and are thus ...
openaire   +2 more sources

Role of Integrin in Cellular Mechanotransduction [PDF]

Biophysical Journal, 2013
Chemical and physical cues from the extracellular matrix (ECM) are used as input for an integrated mechanochemical sensory system that controls cell behavior. Forces derived from the ECM have been implicated in various biological systems, including mesenchymal stem cell differentiation and tumor growth.
Balcioglu, H.E., Danen, E.H.J.
openaire   +2 more sources

A small scale cell culture system to analyze mechanobiology using reporter gene constructs and polyurethane dishes [PDF]

European Cells & Materials, 2010
Mechanical forces are translated into biochemical signals and contribute to cell differentiation and phenotype maintenance. Mesenchymal stem cells and their tissue-specific offspring, as osteoblasts and chondrocytes, cells of cardiovascular tissues and ...
W Wilke, F Jakob, R Ebert, A Ignatius, M Schieker, L Claes, D Docheva, A Liedert, M Kassem, T Lind, B Mentrup, M Kober, T Schwarz, S Mueller-Deubert, L Seefried   +14 more
doaj  

Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm
Cell mechanics is a fundamental regulator of numerous cellular processes, orchestrating critical biological activities spanning from embryogenesis to senescence.
Yicen Long, Peng Wang, Jiacheng Lei, Baihai Su, Qiang Wei, Xiaojing Liu   +5 more
doaj   +1 more source

New insights into Wnt - Lrp5/6 - β-catenin signaling in mechanotransduction

Frontiers in Endocrinology, 2015
Mechanical loading is essential to maintain normal bone metabolism and the balance between bone formation and resorption. The cellular mechanisms that control mechanotransduction are not fully defined, but several key pathways have been identified.
Alexander eRobling, Kyung Shin eKang
doaj   +1 more source