Results 31 to 40 of about 1,227,852 (247)

A trio of biological rhythms and their relevance in rhythmic mechanical stimulation of cell cultures

Frontiers in Psychology, 2022
The primary aim of this article is to provide a biological rhythm model based on previous theoretical and experimental findings to promote more comprehensive studies of rhythmic mechanical stimulation of cell cultures, which relates to tissue engineering
Dongho Kwak, Petter Angell Olsen, Petter Angell Olsen, Anne Danielsen, Alexander Refsum Jensenius   +4 more
doaj   +1 more source

Cell mechanotransduction machinery, and signaling defects: small tools and nano-bio interface for influential regenerative remedies [PDF]

, 2021
© 2021 The Authors. Published by Longdom Publishing. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://www.longdom.org/open-access ...
Kumar, Rajiv, Gulia, Kiran
core   +3 more sources

A small scale cell culture system to analyze mechanobiology using reporter gene constructs and polyurethane dishes [PDF]

European Cells & Materials, 2010
Mechanical forces are translated into biochemical signals and contribute to cell differentiation and phenotype maintenance. Mesenchymal stem cells and their tissue-specific offspring, as osteoblasts and chondrocytes, cells of cardiovascular tissues and ...
W Wilke, F Jakob, R Ebert, A Ignatius, M Schieker, L Claes, D Docheva, A Liedert, M Kassem, T Lind, B Mentrup, M Kober, T Schwarz, S Mueller-Deubert, L Seefried   +14 more
doaj  

Optogenetic control of cellular forces and mechanotransduction

Nature Communications, 2017
Cellular mechanical forces are regulated by Rho GTPases. Here the authors develop an optogenetic system to control the spatiotemporal activity of RhoA, and show that directing a RhoA activator to the plasma membrane causes contraction and YAP nuclear ...
Léo Valon, Ariadna Marín-Llauradó, Thomas Wyatt, Guillaume Charras, Xavier Trepat   +4 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Mechanotransduction for therapeutic approaches: Cellular aging and rejuvenation

APL Bioengineering
Mechanotransduction regulates cytoskeletal remodeling, nuclear mechanics, and metabolic adaptation, which are central to cellular aging and rejuvenation.
Hye-Min Han, Su-Yeon Kim, Dong-Hwee Kim
doaj   +1 more source

Reversible Tuning of Multiple Molecular Kinking for Stem Cell Regulation In Vivo

Advanced Functional Materials, EarlyView.
In this work, we introduce the novel concept of background component‐free “multiple kinks” material platform composed solely of liganded multiple kink‐bearing molecules as a strategy for dynamic biomaterial design. Tri‐kink molecules enable effective near‐infrared light‐triggered ligand masking and visible light‐triggered ligand exposure, thereby ...
Kanghyeon Kim, Jeongah Shin, Chowon Kim, Honghwan Choi, Dahee Kim, Sungkyu Lee, Choongmo Kang, Hyunsik Hong, Taehoon Ha, Nayeon Kang, Jungyeon Rhi, Ramar Thangam, Yuri Kim, Jeongyun Heo, Cheol Hwan Kwak, Jangsun Hwang, Daun Jeong, Rasoul Moradi, Sunghoon Hur, Hyun‐Cheol Song, Hyun‐Do Jung, Min Jae Lee, Rongqin Huang, Pooyan Makvandi, Yun Suk Huh, Ji Hye Choi, Wenguo Cui, Sehoon Kim, Heemin Kang   +28 more
wiley   +1 more source

Intranuclear Delivery of DNA Nanostructures via Cellular Mechanotransduction

, 2022
DNA nanostructures are attractive gene carriers for nanomedicine applications, yet their delivery to the nucleus remains inefficient. We present the application of extracellular mechanical stimuli to activate cellular mechanotransduction for boosting the
Huize Li (7041356), Xiao Yu Tian, Xiao Yu Tian (7887332), Shaorui Liu, Leo Kit Cheung Lee (7887326), Lok Wai Cola Ho (5937473), Cecilia Ka Wing Chan (7041362), Cecilia Ka Wing Chan, Chung Hang Jonathan Choi (4092850), Huize Li, Lok Wai Cola Ho, Shaorui Liu (7887320), Leo Kit Cheung Lee, Chung Hang Jonathan Choi   +13 more
core   +1 more source

Bio‐Inspired Artificial Ionic Mechanoreceptor

Advanced Functional Materials, EarlyView.
A skin‐inspired artificial mechanoreceptor based on ionic interactions is presented for biomimetic tactile sensing. Pressure‐driven ionic redistribution within microfluidic channels generates a self‐powered electrical signal without external bias. The generated waveform exhibits mechanoreceptor‐like temporal features, including overshoot and undershoot,
Mohammad Akbari, Jeppe Don, Lasse A. N. Pedersen, John Noee, Rassoul Tabassian   +4 more
wiley   +1 more source

Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm
Cell mechanics is a fundamental regulator of numerous cellular processes, orchestrating critical biological activities spanning from embryogenesis to senescence.
Yicen Long, Peng Wang, Jiacheng Lei, Baihai Su, Qiang Wei, Xiaojing Liu   +5 more
doaj   +1 more source