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Review of cellular mechanotransduction [PDF]
Journal of Physics D: Applied Physics, 2017 Abstract Living cells and tissues experience physical forces and chemical stimuli in the human body. The process of converting mechanical forces into biochemical activities and gene expression is mechanochemical transduction or mechanotransduction.
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AIMS Biophysics, 2016 Cell adhesion and cell–cell contacts are pre-requisites for proper metabolism, protein synthesis, cell survival, and cancer metastasis. Major transmembrane receptors are the integrins, which are responsible for cell matrix adhesions, and the cadherins, which are important for cell-cell adhesions. Adherent cells are anchored via focal adhesions ...
Wolfgang H. Goldmann, José Luis Alonso
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Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart. [PDF]
PLoS Genetics, 2010 Mechanotransduction modulates cellular functions as diverse as migration, proliferation, differentiation, and apoptosis. It is crucial for organ development and homeostasis and leads to pathologies when defective.
Sébastien Sénatore +4 more
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Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology, 2010 Cells in the musculoskeletal system are subjected to various mechanical forces in vivo. Years of research have shown that these mechanical forces, including tension and compression, greatly influence various cellular functions such as gene expression ...
Wang James HC, Li Bin
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The Cellular Mastermind(?)—Mechanotransduction and the Nucleus [PDF]
, 2014 Cells respond to mechanical stimulation by activation of specific signaling pathways and genes that allow the cell to adapt to its dynamic physical environment. How cells sense the various mechanical inputs and translate them into biochemical signals remains an area of active investigation.
Ashley, Kaminski +2 more
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Pharmaceuticals, 2020 Recent studies undoubtedly show that the mammalian target of rapamycin (mTOR) and the Hippo–Yes-associated protein 1 (YAP) pathways are important mediators of mechanical cues.
Adam Frtús +12 more
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Mechanosignals in abdominal aortic aneurysms
Frontiers in Cardiovascular Medicine, 2023 Cumulative evidence has shown that mechanical and frictional forces exert distinct effects in the multi-cellular aortic layers and play a significant role in the development of abdominal aortic aneurysms (AAA).
Christiana Lowis +14 more
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Control of cell differentiation by mechanical stress
Journal of Physical Fitness and Sports Medicine, 2013 Cells sense mechanical force and their physical environment to change their fate and behavior through mechanotransduction. The mechanotransduction is, by translating mechanical forces and deformations into biochemical intracellular signaling, changing ...
Jong-Hoon Park +2 more
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Cellular Mechanosensitivity: Validation of an Adaptable 3D-Printed Device for Microindentation
Nanomaterials, 2022 Mechanotransduction refers to the cellular ability to sense mechanical stimuli from the surrounding environment and convert them into biochemical signals that regulate cellular physiology and homeostasis.
Giulio Capponi +7 more
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Cell Mechanotransduction With Piconewton Forces Applied by Optical Tweezers
Frontiers in Cellular Neuroscience, 2018 Mechanical stresses are always present in the cellular environment and mechanotransduction occurs in all cells. Although many experimental approaches have been developed to investigate mechanotransduction, the physical properties of the mechanical ...
Fabio Falleroni +4 more
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