Results 21 to 30 of about 43,729 (258)

Role of Mechanotransduction in Cellular Processes [PDF]

Biophysical Journal, 2009
The role of mechanical properties of cells is gaining increasing attention due to the regulatory role that it plays in cellular processes. In particular the transduction of an applied force on the cell membrane through the cellular components can have significant influence on such phenomena as stochasticity in gene expression and cancer metastasis.
Srividya, Narayanan, Balandaram, Gayathri, Bandaranayake, Chandima, Muralidharan, Subra   +3 more
openaire   +1 more source

Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids [PDF]

, 2019
Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Alex, Alpha L., Booth, Kevin T., Hashino, Eri, Koehler, Karl R., Lee, Jiyoon, Nelson, Rick F., Nie, Jing, Roth, Adam A., Tang, Pei-Ciao   +8 more
core   +1 more source

Traction Force Microscopy for Understanding Cellular Mechanotransduction

BMB Reports, 2020
Under physiological and pathological conditions, mechanical forces generated from cells themselves or transmitted from extracellular matrix (ECM) through focal adhesions (FAs) and adherens junctions (AJs) are known to play a significant role in regulating various cell behaviors.
Hur, Sung Sik, Jeong, Ji Hoon, Ban, Myung Jin, Park, Jae Hong, Yoon, Jeong Kyo, Hwang, Yongsung   +5 more
openaire   +3 more sources

Flow-dependent cellular mechanotransduction in atherosclerosis

Journal of Cell Science, 2013
Atherosclerosis depends on risk factors such as hyperlipidemia, smoking, hypertension and diabetes. Although these risk factors are relatively constant throughout the arterial circulation, atherosclerotic plaques occur at specific sites where flow patterns are disturbed, with lower overall magnitude and complex changes in speed and direction.
Daniel E, Conway, Martin A, Schwartz
openaire   +3 more sources

Role of Integrin in Cellular Mechanotransduction [PDF]

Biophysical Journal, 2013
Chemical and physical cues from the extracellular matrix (ECM) are used as input for an integrated mechanochemical sensory system that controls cell behavior. Forces derived from the ECM have been implicated in various biological systems, including mesenchymal stem cell differentiation and tumor growth.
Balcioglu, H.E., Danen, E.H.J.
openaire   +2 more sources

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion [PDF]

, 2016
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to favour cancer ...
Attwood, S, Auernheimer, V, Chronopoulos, A, Cortes, E, Del Rio Hernandez, AE, Fabry, B, Garcia, R, Ghassemi, S, Lachowski, D, Robinson, B, Sarper, M   +10 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Shc and the mechanotransduction of cellular anchorage and metastasis [PDF]

Small GTPases, 2017
Tissue cells continually monitor anchorage conditions by gauging the physical properties of their underlying matrix and surrounding environment. The Rho and Ras GTPases are essential components of these mechanosensory pathways. These molecular switches control both cytoskeletal as well as cell fate responses to anchorage conditions and are thus ...
openaire   +2 more sources

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation. [PDF]

, 2017
Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusceptible regions ...
Bailey, Keith A, Haj, Fawaz G, Passerini, Anthony G, Simon, Scott I   +3 more
core   +1 more source