Results 21 to 30 of about 1,227,852 (247)

Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart. [PDF]

PLoS Genetics, 2010
Mechanotransduction modulates cellular functions as diverse as migration, proliferation, differentiation, and apoptosis. It is crucial for organ development and homeostasis and leads to pathologies when defective.
Sébastien Sénatore, Vatrapu Rami Reddy, Michel Sémériva, Laurent Perrin, Nathalie Lalevée   +4 more
doaj   +1 more source

A genomics approach in determining nanotopographical effects on MSC phenotype [PDF]

, 2013
Topography and its effects on cell adhesion, morphology, growth and differentiation are well documented. Thus, current advances with the use of nanotopographies offer promising results in the field of regenerative medicine.
Tsimbouri, P.M., Herzyk, Pawel, Tsimbouri, Penelope M., Murawski, Kate, Hamilton, Graham, Oreffo, Richard O.C., Gadegaard, Nikolaj, Dalby, Matthew J.   +7 more
core   +1 more source

Hepatic Tumor Cell Morphology Plasticity under Physical Constraints in 3D Cultures Driven by YAP–mTOR Axis

Pharmaceuticals, 2020
Recent studies undoubtedly show that the mammalian target of rapamycin (mTOR) and the Hippo–Yes-associated protein 1 (YAP) pathways are important mediators of mechanical cues.
Adam Frtús, Barbora Smolková, Mariia Uzhytchak, Mariia Lunova, Milan Jirsa, Martin Hof, Piotr Jurkiewicz, Vladimir I. Lozinsky, Lucie Wolfová, Yuriy Petrenko, Šárka Kubinová, Alexandr Dejneka, Oleg Lunov   +12 more
doaj   +1 more source

Mechanics rules cell biology

Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology, 2010
Cells in the musculoskeletal system are subjected to various mechanical forces in vivo. Years of research have shown that these mechanical forces, including tension and compression, greatly influence various cellular functions such as gene expression ...
Wang James HC, Li Bin
doaj   +1 more source

Mechanosignals in abdominal aortic aneurysms

Frontiers in Cardiovascular Medicine, 2023
Cumulative evidence has shown that mechanical and frictional forces exert distinct effects in the multi-cellular aortic layers and play a significant role in the development of abdominal aortic aneurysms (AAA).
Christiana Lowis, Christiana Lowis, Aurellia Ramara Winaya, Aurellia Ramara Winaya, Puja Kumari, Puja Kumari, Cristobal F. Rivera, Cristobal F. Rivera, John Vlahos, John Vlahos, Rio Hermantara, Muhammad Yogi Pratama, Muhammad Yogi Pratama, Bhama Ramkhelawon, Bhama Ramkhelawon   +14 more
doaj   +1 more source

High-throughput optical screening of cellular mechanotransduction [PDF]

, 2014
We introduce an optical platform for rapid, high-throughput screening of exogenous molecules that affect cellular mechanotransduction. Our method initiates mechanotransduction in adherent cells using single laser-microbeam generated microcavitation ...
Compton, Jonathan L, Luo, Justin C, Luo, JC, Compton, JL, Venugopalan, V, Ma, H, Botvinick, Elliot, Huan Ma, Vasan Venugopalan, Elliot Botvinick, Ma, Huan, Jonathan L. Compton, Botvinick, E, Justin C. Luo, Venugopalan, Vasan   +14 more
core   +1 more source

Control of cell differentiation by mechanical stress

Journal of Physical Fitness and Sports Medicine, 2013
Cells sense mechanical force and their physical environment to change their fate and behavior through mechanotransduction. The mechanotransduction is, by translating mechanical forces and deformations into biochemical intracellular signaling, changing ...
Jong-Hoon Park, Takashi Ushida, Takayuki Akimoto   +2 more
doaj   +1 more source

Cellular Mechanosensitivity: Validation of an Adaptable 3D-Printed Device for Microindentation

Nanomaterials, 2022
Mechanotransduction refers to the cellular ability to sense mechanical stimuli from the surrounding environment and convert them into biochemical signals that regulate cellular physiology and homeostasis.
Giulio Capponi, Martina Zambito, Igor Neri, Francesco Cottone, Maurizio Mattarelli, Massimo Vassalli, Silvia Caponi, Tullio Florio   +7 more
doaj   +1 more source

Determination of cellular strains by combined atomic force microscopy and finite element modeling [PDF]

, 2002
Many organs adapt to their mechanical environment as a result of physiological change or disease. Cells are both the detectors and effectors of this process.
Charras, GT, Charras, Guillaume T., Horton, MA, Horton, Mike A.   +3 more
core   +1 more source

3D Cell Culture for the Study of Microenvironment-Mediated Mechanostimuli to the Cell Nucleus: An Important Step for Cancer Research

Frontiers in Molecular Biosciences, 2021
The discovery that the stiffness of the tumor microenvironment (TME) changes during cancer progression motivated the development of cell culture involving extracellular mechanostimuli, with the intent of identifying mechanotransduction mechanisms that ...
Apekshya Chhetri, Apekshya Chhetri, Joseph V. Rispoli, Joseph V. Rispoli, Sophie A. Lelièvre, Sophie A. Lelièvre   +5 more
doaj   +1 more source