Results 11 to 20 of about 43,729 (258)
Biophysical Tools to Study Cellular Mechanotransduction [PDF]
Bioengineering, 2017 The cell membrane is the interface that volumetrically isolates cellular components from the cell’s environment. Proteins embedded within and on the membrane have varied biological functions: reception of external biochemical signals, as membrane ...
Chowdhury, Farhan +2 more
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The energetics of rapid cellular mechanotransduction
Proceedings of the National Academy of Sciences, 2022 Cells throughout the human body detect mechanical forces. While it is known that the rapid (millisecond) detection of mechanical forces is mediated by force-gated ion channels, a detailed quantitative understanding of cells as sensors of mechanical energy is still lacking.
Michael N. Young +4 more
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Effect of aging on cellular mechanotransduction [PDF]
Ageing Research Reviews, 2011 Aging is becoming a critical heath care issue and a burgeoning economic burden on society. Mechanotransduction is the ability of the cell to sense, process, and respond to mechanical stimuli and is an important regulator of physiologic function that has been found to play a role in regulating gene expression, protein synthesis, cell differentiation ...
Miaozong, Wu +4 more
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Cellular Mechanotransduction: From Tension to Function [PDF]
Frontiers in Physiology, 2018 Living cells are constantly exposed to mechanical stimuli arising from the surrounding extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes through which such physical cues are transformed into a biological response are collectively dubbed as mechanotransduction and are of fundamental importance to help the cell ...
Fabiana Martino +9 more
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Tailoring Cellular Function: The Contribution of the Nucleus in Mechanotransduction [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Cells sense a variety of different mechanochemical stimuli and promptly react to such signals by reshaping their morphology and adapting their structural organization and tensional state. Cell reactions to mechanical stimuli arising from the local microenvironment, mechanotransduction, play a crucial role in many cellular functions in both ...
Fabrizio A. Pennacchio +4 more
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Talin Folding as the Tuning Fork of Cellular Mechanotransduction [PDF]
Proceedings of the National Academy of Sciences, 2020 Cells continually sample their mechanical environment using exquisite force sensors such as talin, whose folding status triggers mechanotransduction pathways by recruiting binding partners. Mechanical signals in biology change quickly over time and are often embedded in noise; however, the mechanics of force-sensing proteins have only been tested using
Tapia-Rojo, Rafael +2 more
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Review of cellular mechanotransduction [PDF]
Journal of Physics D: Applied Physics, 2017 Living cells and tissues experience physical forces and chemical stimuli in a human body. The process of converting mechanical forces into biochemical activities and gene expression is mechanochemical transduction or mechanotransduction. Significant advances have been made in understanding mechanotransduction at cellular and molecular levels over the ...
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AIMS Biophysics, 2016 Cell adhesion and cell–cell contacts are pre-requisites for proper metabolism, protein synthesis, cell survival, and cancer metastasis. Major transmembrane receptors are the integrins, which are responsible for cell matrix adhesions, and the cadherins, which are important for cell-cell adhesions. Adherent cells are anchored via focal adhesions ...
Wolfgang H. Goldmann, José Luis Alonso
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The Cellular Mastermind(?)—Mechanotransduction and the Nucleus [PDF]
, 2014 Cells respond to mechanical stimulation by activation of specific signaling pathways and genes that allow the cell to adapt to its dynamic physical environment. How cells sense the various mechanical inputs and translate them into biochemical signals remains an area of active investigation.
Ashley, Kaminski +2 more
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Optogenetic control of cellular forces and mechanotransduction [PDF]
Nature Communications, 2017 AbstractContractile forces are the end effectors of cell migration, division, morphogenesis, wound healing and cancer invasion. Here we report optogenetic tools to upregulate and downregulate such forces with high spatiotemporal accuracy. The technology relies on controlling the subcellular activation of RhoA using the CRY2/CIBN light-gated dimerizer ...
Valon, Léo +4 more
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