Results 11 to 20 of about 24,624 (157)
Cellular Mechanotransduction: From Tension to Function [PDF]
Frontiers in Physiology, 2018 Living cells are constantly exposed to mechanical stimuli arising from the surrounding extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes through which such physical cues are transformed into a biological response
Fabiana Martino +9 more
doaj +4 more sources
Biophysical Tools to Study Cellular Mechanotransduction [PDF]
Bioengineering, 2017 The cell membrane is the interface that volumetrically isolates cellular components from the cell’s environment. Proteins embedded within and on the membrane have varied biological functions: reception of external biochemical signals, as membrane ...
Ismaeel Muhamed +2 more
doaj +4 more sources
Optogenetic control of cellular forces and mechanotransduction [PDF]
Nature Communications, 2017 Cellular mechanical forces are regulated by Rho GTPases. Here the authors develop an optogenetic system to control the spatiotemporal activity of RhoA, and show that directing a RhoA activator to the plasma membrane causes contraction and YAP nuclear ...
Léo Valon +4 more
doaj +5 more sources
Cellular mechanotransduction of human osteoblasts in microgravity
npj MicrogravityAstronauts experience significant and rapid bone loss as a result of an extended stay in space, making the International Space Station (ISS) the perfect laboratory for studying osteoporosis due to the accelerated nature of bone loss on the ISS.
Nadab H. Wubshet +16 more
doaj +4 more sources
Tailoring Cellular Function: The Contribution of the Nucleus in Mechanotransduction [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Cells sense a variety of different mechanochemical stimuli and promptly react to such signals by reshaping their morphology and adapting their structural organization and tensional state.
Fabrizio A. Pennacchio +4 more
doaj +4 more sources
Mechanotransduction for therapeutic approaches: Cellular aging and rejuvenation
APL BioengineeringMechanotransduction regulates cytoskeletal remodeling, nuclear mechanics, and metabolic adaptation, which are central to cellular aging and rejuvenation.
Hye-Min Han, Su-Yeon Kim, Dong-Hwee Kim
doaj +3 more sources
Cellular responses to beating hydrogels to investigate mechanotransduction [PDF]
Nature Communications, 2019 Mechanotransduction of cells is of interest for a number of reasons but model in vitro systems remain a challenge. Here, the authors report on a hydrogel which changes properties upon near infrared irradiation to create cyclic forces and demonstrate the ...
Yashoda Chandorkar +10 more
doaj +3 more sources
The energetics of rapid cellular mechanotransduction
Proceedings of the National Academy of Sciences, 2022 Cells throughout the human body detect mechanical forces. While it is known that the rapid (millisecond) detection of mechanical forces is mediated by force-gated ion channels, a detailed quantitative understanding of cells as sensors of mechanical energy is still lacking.
Michael N. Young +4 more
openaire +2 more sources
Effect of aging on cellular mechanotransduction [PDF]
Ageing Research Reviews, 2011 Aging is becoming a critical heath care issue and a burgeoning economic burden on society. Mechanotransduction is the ability of the cell to sense, process, and respond to mechanical stimuli and is an important regulator of physiologic function that has been found to play a role in regulating gene expression, protein synthesis, cell differentiation ...
Miaozong, Wu +4 more
openaire +2 more sources
Talin Folding as the Tuning Fork of Cellular Mechanotransduction [PDF]
Proceedings of the National Academy of Sciences, 2020 Cells continually sample their mechanical environment using exquisite force sensors such as talin, whose folding status triggers mechanotransduction pathways by recruiting binding partners. Mechanical signals in biology change quickly over time and are often embedded in noise; however, the mechanics of force-sensing proteins have only been tested using
Tapia-Rojo, Rafael +2 more
openaire +2 more sources