Results 41 to 50 of about 24,624 (157)
Phosphoinositide Signaling and Mechanotransduction in Cardiovascular Biology and Disease
Frontiers in Cell and Developmental Biology, 2020 Phosphoinositides, which are membrane-bound phospholipids, are critical signaling molecules located at the interface between the extracellular matrix, cell membrane, and cytoskeleton.
Amanda Krajnik +6 more
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Biomimetic substrate control of cellular mechanotransduction
Biomaterials Research, 2016 Abstract Extracellular mechanophysical signals from both static substrate cue and dynamic mechanical loading have strong potential to regulate cell functions. Most of the studies have adopted either static or dynamic cue and shown that each cue can regulate cell adhesion, spreading, migration, proliferation, lineage commitment, and ...
Andalib, Mohammad Nahid +3 more
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The contribution of cellular mechanotransduction to cardiomyocyte form and function [PDF]
Biomechanics and Modeling in Mechanobiology, 2012 Myocardial development is regulated by an elegantly choreographed ensemble of signaling events mediated by a multitude of intermediates that take a variety of forms. Cellular differentiation and maturation are a subset of vertically integrated processes that extend over several spatial and temporal scales to create a well-defined collective of cells ...
Sean P, Sheehy +2 more
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Cellular Mechanotransduction: Filamin A Strains to Regulate Motility [PDF]
Current Biology, 2011 A new study suggests that mechanical strain through the actin-binding protein filamin A leads to increased linkage between the extracellular matrix and cytoskeleton and decreased actin dynamics.
Lynch, C.D., Sheetz, M.P.
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BMC Bioinformatics, 2020 Background Mechanotransduction in bone cells plays a pivotal role in osteoblast differentiation and bone remodelling. Mechanotransduction provides the link between modulation of the extracellular matrix by mechanical load and intracellular activity.
Gianluca Ascolani +4 more
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High-throughput optical screening of cellular mechanotransduction [PDF]
Nature Photonics, 2014 We introduce an optical platform for rapid, high-throughput screening of exogenous molecules that affect cellular mechanotransduction. Our method initiates mechanotransduction in adherent cells using single laser-microbeam generated micro-cavitation bubbles (μCBs) without requiring flow chambers or microfluidics.
Compton, JL +4 more
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Mechanotransduction mechanisms in growing spherically structured tissues
New Journal of Physics, 2018 There is increasing experimental interest in mechanotransduction in multi-cellular tissues as opposed to single cells. This is driven by a growing awareness of the importance of physiologically relevant three-dimensional culture and of cell–cell and cell–
Euan Littlejohns, Carina M. Dunlop
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Osteocyte: a Cellular Basis for Mechanotransduction in Bone
Journal of Biomechanical Science and Engineering, 2007 Osteocyte is the most abundant cell type in bone, and the only cell type located inside the mineralized matrix. The striking structural design of bone predicts an important role for osteocytes in determining bone structure and function.
Guoliang GU +3 more
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Frontiers in Physics, 2022 Cellular mechanotransduction is a common mechanism by which cells convert mechanical cues (or stimuli) from their environment into biochemical and cellular responses.
L. P. Bergeron-Sandoval +9 more
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Gold-tipped elastomeric pillars for cellular mechanotransduction [PDF]
Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures Processing, Measurement, and Phenomena, 2009 The authors describe a technique for the fabrication of arrays of elastomeric pillars whose top surfaces are treated with selective chemical functionalization to promote cellular adhesion in cellular force transduction experiments. The technique involves the creation of a rigid mold consisting of arrays of circular holes into which a thin layer of Au ...
S, Ghassemi +4 more
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