Results 41 to 50 of about 1,227,852 (247)
Phosphoinositide Signaling and Mechanotransduction in Cardiovascular Biology and Disease
Frontiers in Cell and Developmental Biology, 2020 Phosphoinositides, which are membrane-bound phospholipids, are critical signaling molecules located at the interface between the extracellular matrix, cell membrane, and cytoskeleton.
Amanda Krajnik +6 more
doaj +1 more source
Advanced Functional Materials, EarlyView.This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu +14 more
wiley +1 more source
New insights into Wnt - Lrp5/6 - β-catenin signaling in mechanotransduction
Frontiers in Endocrinology, 2015 Mechanical loading is essential to maintain normal bone metabolism and the balance between bone formation and resorption. The cellular mechanisms that control mechanotransduction are not fully defined, but several key pathways have been identified.
Alexander eRobling, Kyung Shin eKang
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira +8 more
wiley +1 more source
Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration
Advanced Healthcare Materials, EarlyView.This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu +4 more
wiley +1 more source
Osteocyte: a Cellular Basis for Mechanotransduction in Bone
Journal of Biomechanical Science and Engineering, 2007 Osteocyte is the most abundant cell type in bone, and the only cell type located inside the mineralized matrix. The striking structural design of bone predicts an important role for osteocytes in determining bone structure and function.
Guoliang GU +3 more
doaj +1 more source
Optical Detection of Cellular Signals at Material Interfaces
Advanced Healthcare Materials, EarlyView.Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren +5 more
wiley +1 more source
Biophysics of Mechanotransduction
, 2015 Mechanosensory transduction is ancient, paralleling the \ud appearance of the first primordial cells on the surface of the Earth some 3.8 billion years ago.
Martinac, B, Battle, Andrew R.
core +1 more source
Mechanotransduction: Use the Force(s) [PDF]
, 2015 Mechanotransduction - how cells sense physical forces and translate them into biochemical and biological responses - is a vibrant and rapidly-progressing field, and is important for a broad range of biological phenomena.
Rehfeldt, Florian +9 more
core +6 more sources
Mechanotransduction mechanisms in growing spherically structured tissues
New Journal of Physics, 2018 There is increasing experimental interest in mechanotransduction in multi-cellular tissues as opposed to single cells. This is driven by a growing awareness of the importance of physiologically relevant three-dimensional culture and of cell–cell and cell–
Euan Littlejohns, Carina M. Dunlop
doaj +1 more source