Results 61 to 70 of about 24,624 (157)

Emerging mechanomedicines informed by mechanotransduction along the integrin–cytoskeleton–nucleus axis

APL Bioengineering
Mechanical forces are fundamental to the formation of normal biological tissues and the maintenance of physiological health. These forces are transmitted from the extracellular environment to the cell interior through cell–cell and cell–ECM interactions,
Yuka Yokoyama, Nya Domkam, Hannaneh Kabir, Abdullah Mansour, Shingo Tsukamoto, Ghafar Yerima, Taiji Adachi, Mohammad R. K. Mofrad   +7 more
doaj   +1 more source

Deciphering Nuclear Mechanobiology in Laminopathy

Cells, 2019
Extracellular mechanical stimuli are translated into biochemical signals inside the cell via mechanotransduction. The nucleus plays a critical role in mechanoregulation, which encompasses mechanosensing and mechanotransduction.
Jungwon Hah, Dong-Hwee Kim
doaj   +1 more source

The Role of Connections Between Cellular and Tissue Mechanical Elements and the Importance of Applied Energy in Mechanotransduction in Cancerous Tissue

Biomolecules
In the presence of cellular mutations and impaired mechanisms of energy transmission to the attached cells and tissues, excess energy is available to upregulate some of the mechanotransduction pathways that maintain cell and tissue structure and function.
Frederick H. Silver
doaj   +1 more source

The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives

Frontiers in Immunology
Organ fibrosis represents a final common pathway of chronic tissue injury, characterized by persistent extracellular matrix (ECM) accumulation and progressive loss of organ function.
Chao Lei, Dongjie Wu, Houyan Zhang, Zhiya Yang, Bohao Huang, Jie Wang, Yanbo Li, Wenliang Lv   +7 more
doaj   +1 more source

PPy‐Coated Wire Actuators for the Micromechanostimulation of Cells: Fabrication and Characterization

Small Science
Cellular mechanotransduction signals play a crucial role in physiological and pathological conditions, including skeletal disorders. Although various systems exist to mechanically stimulate cultured cells, most are constrained by incubator ...
Amaia B. Ortega‐Santos, Satoru Hayano, Emilio Satoshi Hara, Jose G. Martínez, Hiroshi Kamioka, Edwin W. H. Jager   +5 more
doaj   +1 more source

Emerin acts as a mechanosensor linking force transmission and disease

Frontiers in Oncology
For cells to respond to mechanical and biochemical cues in their environment, signals from the extracellular environment must be transmitted across the plasma membrane and into the nucleus to create the correct physical, transcriptional, and biochemical ...
Emily Hansen, Emily Hansen, James M. Holaska, James M. Holaska   +3 more
doaj   +1 more source

Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading

iScience
Summary: Cells sense mechanical cues and convert them into biochemical responses to regulate biological processes such as embryonic development, aging, cellular homeostasis, and disease progression.
Pei-Li Tseng, Weiwei Sun, Ahmed Salem, Mubarak Alaklobie, Sarah C. Macfarlane, Annica K.B. Gad, Mark O. Collins, Kai S. Erdmann   +7 more
doaj   +1 more source

Autoantibodies immuno-mechanically modulate platelet contractile force and bleeding risk

Nature Communications
Altered mechanotransduction has been proposed as a putative mechanism for disease pathophysiology, yet evidence remains scarce. Here we introduce a concept we call single cell immuno-mechanical modulation, which links immunology, integrin biology ...
Oluwamayokun Oshinowo, Renee Copeland, Anamika Patel, Nina Shaver, Meredith E. Fay, Rebecca Jeltuhin, Yijin Xiang, Christina Caruso, Adiya E. Otumala, Sarah Hernandez, Priscilla Delgado, Gabrielle Dean, James M. Kelvin, Daniel Chester, Ashley C. Brown, Erik C. Dreaden, Traci Leong, Jesse Waggoner, Renhao Li, Eric Ortlund, Carolyn Bennett, Wilbur A. Lam, David R. Myers   +22 more
doaj   +1 more source

Mechanotransduction, cellular biophotonic activity, and signaling patterns for tissue regeneration. [PDF]

J Biol Chem
Cavallini C, Olivi E, Tassinari R, Ventura C.   +3 more
europepmc   +1 more source

Chronic Radiation Dermatitis After Breast Cancer Radiotherapy: Mechanistic Insights, Therapeutic Challenges, and Emerging Roles of Piezo1-Mediated Mechanotransduction. [PDF]

J Inflamm Res
Wang Z, Chen F, Li Z.
europepmc   +1 more source