Results 71 to 80 of about 1,227,852 (247)

An overview of mechanical microenvironment and mechanotransduction in intervertebral disc degeneration

Experimental and Molecular Medicine
Cellular mechanotransduction, essential for many biological functions, involves the conversion of mechanical signals into biochemical signals related to cell activities and metabolism.
Wencan Ke, Hanpeng Xu, Chengyi Zhang, Zhiwei Liao, Huaizhen Liang, Bide Tong, Feijun Yuan, Kun Wang, Wenbin Hua, Bingjin Wang, Cao Yang   +10 more
doaj   +1 more source

Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation

Stem Cells International, 2019
The cellular response to the extracellular matrix (ECM) microenvironment mediated by integrin adhesion is of fundamental importance, in both developmental and pathological processes.
Rosaria Santoro, Gianluca Lorenzo Perrucci, Aoife Gowran, Giulio Pompilio   +3 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Integrin-mediated mechanotransduction [PDF]

, 2016
Cells can detect and react to the biophysical properties of the extracellular environment through integrin-based adhesion sites and adapt to the extracellular milieu in a process called mechanotransduction.
Guo, S., Shengzhen S. Guo, Fässler, R., Reinhard Fässler, Sun, Z., Zhiqi Sun   +5 more
core   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

A Unified Map of Airway Interactions: Secretome and Mechanotransduction Loops from Development to Disease

Advances in Respiratory Medicine
Human airways maintain homeostasis through intricate cellular interactomes combining secretome-mediated signalling and mechanotransduction feedback loops.
Crizaldy Tugade, Jopeth Ramis
doaj   +1 more source

A TR(i)P to Cell Migration: New Roles of TRP Channels in Mechanotransduction and Cancer

Frontiers in Physiology, 2019
Cell migration is a key process in cancer metastasis, allowing malignant cells to spread from the primary tumor to distant organs. At the molecular level, migration is the result of several coordinated events involving mechanical forces and cellular ...
Jimena Canales, Jimena Canales, Diego Morales, Diego Morales, Constanza Blanco, Constanza Blanco, José Rivas, José Rivas, Nicolás Díaz, Nicolás Díaz, Ioannis Angelopoulos, Ioannis Angelopoulos, Oscar Cerda, Oscar Cerda, Oscar Cerda   +14 more
doaj   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

MOLECULES INVOLVED IN THE SPIDER, CUPIENNIUS SALEI, MECHANOTRANSDUCTION

, 2019
The molecular mechanisms involved in mechanical senses such as touch and vibration have been studied for decades using a small number of model preparations in species facilitating genetic manipulation.
Johnson, Jessica
core