Results 51 to 60 of about 24,624 (157)

Dynamic molecular processes mediate cellular mechanotransduction [PDF]

Nature, 2011
Cellular responses to mechanical forces are crucial in embryonic development and adult physiology, and are involved in numerous diseases, including atherosclerosis, hypertension, osteoporosis, muscular dystrophy, myopathies and cancer. These responses are mediated by load-bearing subcellular structures, such as the plasma membrane, cell-adhesion ...
Brenton D, Hoffman, Carsten, Grashoff, Martin A, Schwartz   +2 more
openaire   +2 more sources

The mechanopathology of the tumor microenvironment: detection techniques, molecular mechanisms and therapeutic opportunities

Frontiers in Cell and Developmental Biology
The mechanical properties of the tumor microenvironment (TME) undergo significant changes during tumor growth, primarily driven by alterations in extracellular (ECM) stiffness and tumor viscoelasticity.
Stella Angeli, Constantina Neophytou, Maria Kalli, Triantafyllos Stylianopoulos, Fotios Mpekris   +4 more
doaj   +1 more source

Upregulation of matrix synthesis in chondrocyte-seeded agarose following sustained bi-axial cyclic loading

Clinics, 2012
OBJECTIVES: The promotion of extracellular matrix synthesis by chondrocytes is a requisite part of an effective cartilage tissue engineering strategy.
Belinda Pingguan-Murphy, Illida Nawi
doaj   +1 more source

An overview of mechanical microenvironment and mechanotransduction in intervertebral disc degeneration

Experimental and Molecular Medicine
Cellular mechanotransduction, essential for many biological functions, involves the conversion of mechanical signals into biochemical signals related to cell activities and metabolism.
Wencan Ke, Hanpeng Xu, Chengyi Zhang, Zhiwei Liao, Huaizhen Liang, Bide Tong, Feijun Yuan, Kun Wang, Wenbin Hua, Bingjin Wang, Cao Yang   +10 more
doaj   +1 more source

Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation

Stem Cells International, 2019
The cellular response to the extracellular matrix (ECM) microenvironment mediated by integrin adhesion is of fundamental importance, in both developmental and pathological processes.
Rosaria Santoro, Gianluca Lorenzo Perrucci, Aoife Gowran, Giulio Pompilio   +3 more
doaj   +1 more source

A TR(i)P to Cell Migration: New Roles of TRP Channels in Mechanotransduction and Cancer

Frontiers in Physiology, 2019
Cell migration is a key process in cancer metastasis, allowing malignant cells to spread from the primary tumor to distant organs. At the molecular level, migration is the result of several coordinated events involving mechanical forces and cellular ...
Jimena Canales, Jimena Canales, Diego Morales, Diego Morales, Constanza Blanco, Constanza Blanco, José Rivas, José Rivas, Nicolás Díaz, Nicolás Díaz, Ioannis Angelopoulos, Ioannis Angelopoulos, Oscar Cerda, Oscar Cerda, Oscar Cerda   +14 more
doaj   +1 more source

A Unified Map of Airway Interactions: Secretome and Mechanotransduction Loops from Development to Disease

Advances in Respiratory Medicine
Human airways maintain homeostasis through intricate cellular interactomes combining secretome-mediated signalling and mechanotransduction feedback loops.
Crizaldy Tugade, Jopeth Ramis
doaj   +1 more source

Sensing the squeeze: nuclear mechanotransduction in health and disease

Nucleus
The nucleus not only is a repository for DNA but also a center of cellular and nuclear mechanotransduction. From nuclear deformation to the interplay between mechanosensing components and genetic control, the nucleus is poised at the nexus of mechanical ...
Luv Kishore Srivastava, Allen J. Ehrlicher   +1 more
doaj   +1 more source

Elevation of the mechanically-sensitive protein emerin links nuclear mechanotransduction to tau-induced cytoskeletal remodeling in neurons

Nucleus
Neurodegenerative tauopathies, including Alzheimer’s disease, are neuropathologically defined by pathological tau deposition. While tau drives neurotoxicity by disrupting cytoskeletal, nucleoskeletal, and genomic architecture, cellular mechanisms ...
Claira Sohn, Sammy Pardo, Dana Molleur, Satvik R. Paduri, Morgan Lambert, Zachary Uttke, Erich J. Sohn, Morgan G. Thomas, Susan T. Weintraub, Bess Frost   +9 more
doaj   +1 more source

The Energetics of Rapid Cellular Mechanotransduction [PDF]

Biophysical Journal, 2021
Michael N. Young, Jörg M. Grandl
openaire   +1 more source