The LINC Complex Inhibits Excessive Chromatin Repression [PDF]
Cells, 2023 The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex transduces nuclear mechanical inputs suggested to control chromatin organization and gene expression; however, the underlying mechanism is currently unclear.
Daria Amiad Pavlov +2 more
exaly +8 more sources
Life at the crossroads: the nuclear LINC complex and vascular mechanotransduction [PDF]
Frontiers in PhysiologyVascular endothelial cells line the inner surface of all blood vessels, where they are exposed to polarized mechanical forces throughout their lifespan.
Victoria L Bautch, Bautch Victoria L
exaly +8 more sources
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary [PDF]
Cells, 2022 Mutations in genes encoding proteins associated with the linker of nucleoskeleton and cytoskeleton (LINC) complex within the nuclear envelope cause different diseases with varying phenotypes including skeletal muscle, cardiac, metabolic, or nervous ...
Heidi R Fuller, Fuller Heidi R
exaly +6 more sources
The Role of the LINC Complex in Sperm Development and Function [PDF]
International Journal of Molecular Sciences, 2020 The LINC (LInker of Nucleoskeleton and Cytoskeleton) complex is localized within the nuclear envelope and consists of SUN (Sad1/UNc84 homology domain-containing) proteins located in the inner nuclear membrane and KASH (Klarsicht/Anc1/Syne1 homology ...
Michaela Frolikova +2 more
exaly +6 more sources
Diverse Roles of the LINC Complex in Cellular Function and Disease in the Nervous System [PDF]
International Journal of Molecular SciencesThe linker of nucleoskeleton and cytoskeleton (LINC) complex, which spans the nuclear envelope, physically connects nuclear components to the cytoskeleton and plays a pivotal role in various cellular processes, including nuclear positioning, cell ...
Ken-Ichiro Kuwako, Sadafumi Suzuki
exaly +3 more sources
Life outside the LINC complex – Do SUN proteins have LINC‐independent functions? [PDF]
BioEssaysAbstractSad1 and UNC84 (SUN) and Klarsicht, ANC‐1, and Syne homology (KASH) proteins interact at the nuclear periphery to form the linker of nucleoskeleton and cytoskeleton (LINC) complex, spanning the nuclear envelope (NE) and connecting the cytoskeleton with the nuclear interior.
Christophe Guilluy
exaly +4 more sources
Changes in Nuclear Shape and Gene Expression in Response to Simulated Microgravity Are LINC Complex-Dependent [PDF]
International Journal of Molecular Sciences, 2020 Microgravity is known to affect the organization of the cytoskeleton, cell and nuclear morphology and to elicit differential expression of genes associated with the cytoskeleton, focal adhesions and the extracellular matrix.
Srujana Neelam +2 more
exaly +3 more sources
LINC-complex mediated positioning of the vegetative nucleus is involved in calcium and ROS signaling in Arabidopsis pollen tubes [PDF]
Nucleus, 2020 Nuclear movement and positioning play a role in developmental processes throughout life. Nuclear movement and positioning are mediated primarily by linker of nucleoskeleton and cytoskeleton (LINC) complexes.
Morgan Moser +2 more
exaly +3 more sources
Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole-cell mechanics [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Amir Vahabikashi +2 more
exaly +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source