The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate [PDF]
Journal of Biological Engineering, 2019 Mesenchymal stem cells (MSCs) show tremendous promise as a cell source for tissue engineering and regenerative medicine, and are understood to be mechanosensitive to external mechanical environments. In recent years, increasing evidence points to nuclear
Tasneem Bouzid +7 more
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The Role of the LINC Complex in Sperm Development and Function [PDF]
International Journal of Molecular Sciences, 2020 The LINC (LInker of Nucleoskeleton and Cytoskeleton) complex is localized within the nuclear envelope and consists of SUN (Sad1/UNc84 homology domain-containing) proteins located in the inner nuclear membrane and KASH (Klarsicht/Anc1/Syne1 homology domain-containing) proteins located in the outer nuclear membrane, hence linking nuclear with cytoplasmic
Klaus Steger +2 more
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Life outside the LINC complex – Do SUN proteins have LINC‐independent functions? [PDF]
BioEssaysAbstractSad1 and UNC84 (SUN) and Klarsicht, ANC‐1, and Syne homology (KASH) proteins interact at the nuclear periphery to form the linker of nucleoskeleton and cytoskeleton (LINC) complex, spanning the nuclear envelope (NE) and connecting the cytoskeleton with the nuclear interior.
Christophe Guilluy
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Implications for Diverse Functions of the LINC Complexes Based on the Structure [PDF]
Cells, 2017 The linker of nucleoskeleton and cytoskeleton (LINC) complex is composed of the outer and inner nuclear membrane protein families Klarsicht, Anc-1, and Syne homology (KASH), and Sad1 and UNC-84 (SUN) homology domain proteins.
Miki Hieda
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The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation [PDF]
eLife, 2021 While the mechanisms by which chemical signals control cell fate have been well studied, the impact of mechanical inputs on cell fate decisions is not well understood.
Emma Carley +8 more
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The cytoskeleton dynamics-dependent LINC complex in periodontal ligament stem cells transmits mechanical stress to the nuclear envelope and promotes YAP nuclear translocation [PDF]
Stem Cell Research & TherapyBackground Periodontal ligament stem cells (PDLSCs) are important seed cells in tissue engineering and clinical applications. They are the priority receptor cells for sensing various mechanical stresses.
Xuehuan Meng +9 more
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Prrx1-driven LINC complex disruption in vivo reduces osteoid deposition but not bone quality after voluntary wheel running. [PDF]
PLoS ONEThe Linker of Nucleoskeleton and Cytoskeleton (LINC) complex serves to connect the nuclear envelope and the cytoskeleton, influencing cellular processes such as nuclear arrangement, architecture, and mechanotransduction.
Scott Birks +9 more
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Nuclei on the move: LINC complex-dependent and -independent mechanisms of nuclear migration in development [PDF]
NucleusNuclear positioning drives developmental processes from fertilization to neurogenesis. The linker of nucleoskeleton and cytoskeleton (LINC) complex connects nuclei to cytoskeletal force generators that power nuclear migration.
Selin Gümüşderelioğlu +2 more
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The LINC complex ensures accurate centrosome positioning during prophase [PDF]
Life Science AllianceCentrosome positioning in prophase is essential for efficient spindle assembly. Here, we show that centrosome positioning requires LINC complex–mediated loading of dynein on the nuclear envelope.
Joana T Lima +2 more
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Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole-cell mechanics [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Ming Guo +2 more
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