Results 11 to 20 of about 5,180,956 (219)

The LINC Complex Inhibits Excessive Chromatin Repression [PDF]

Cells, 2023
The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex transduces nuclear mechanical inputs suggested to control chromatin organization and gene expression; however, the underlying mechanism is currently unclear.
Daria Amiad Pavlov, CP Unnikannan, Dana Lorber, Gaurav Bajpai, Tsviya Olender, Elizabeth Stoops, Adriana Reuveny, Samuel Safran, Talila Volk   +8 more
doaj   +8 more sources

Life at the crossroads: the nuclear LINC complex and vascular mechanotransduction [PDF]

Frontiers in Physiology
Vascular endothelial cells line the inner surface of all blood vessels, where they are exposed to polarized mechanical forces throughout their lifespan.
Pauline Bougaran, Victoria L. Bautch, Victoria L. Bautch   +2 more
doaj   +6 more sources

Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary [PDF]

Cells, 2022
Mutations in genes encoding proteins associated with the linker of nucleoskeleton and cytoskeleton (LINC) complex within the nuclear envelope cause different diseases with varying phenotypes including skeletal muscle, cardiac, metabolic, or nervous ...
Emily C. Storey, Heidi R. Fuller
doaj   +4 more sources

The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal [PDF]

Scientific Reports, 2021
The morphology of the Golgi complex is influenced by the cellular context, which strictly correlates with nuclear functions; however, the mechanism underlying this association remains elusive.
Miki Hieda, Taizo Matsumoto, Mari Isobe, Sadamu Kurono, Kaneko Yuka, Satoshi Kametaka, Jing-Ya Wang, Ya-Hui Chi, Kenji Kameda, Hiroshi Kimura, Nariaki Matsuura, Shuji Matsuura   +11 more
doaj   +3 more sources

LINC complex alterations are a key feature of sporadic and familial ALS/FTD [PDF]

Acta Neuropathologica Communications
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects motor neurons, leading to progressive muscle weakness and loss of voluntary muscle control. While the exact cause of ALS is not fully understood, emerging research
Riccardo Sirtori, Michelle J. Gregoire, Emily M. Potts, Alicia Collins, Liviana Donatelli, Claudia Fallini   +5 more
doaj   +3 more sources

The plant LINC complex at the nuclear envelope [PDF]

Chromosome Research, 2014
Significant advances in understanding the plant nuclear envelope have been made over the past few years; indeed, knowledge of the protein network at the nuclear envelope is rapidly growing. One such network, the linker of nucleoskeleton and cytoskeleton (LINC) complex, is known in animals to connect chromatin to the cytoskeleton through the nuclear ...
Tatout, Christophe, Evans, David E, Vanrobays, Emmanuel, Probst, Aline V, Graumann, Katja   +4 more
core   +12 more sources

Diverse Roles of the LINC Complex in Cellular Function and Disease in the Nervous System. [PDF]

Int J Mol Sci
The linker of nucleoskeleton and cytoskeleton (LINC) complex, which spans the nuclear envelope, physically connects nuclear components to the cytoskeleton and plays a pivotal role in various cellular processes, including nuclear positioning, cell ...
Kuwako KI, Suzuki S.
europepmc   +3 more sources

The Role of the LINC Complex in Sperm Development and Function. [PDF]

Int J Mol Sci, 2020
The LINC (LInker of Nucleoskeleton and Cytoskeleton) complex is localized within the nuclear envelope and consists of SUN (Sad1/UNc84 homology domain-containing) proteins located in the inner nuclear membrane and KASH (Klarsicht/Anc1/Syne1 homology domain-containing) proteins located in the outer nuclear membrane, hence linking nuclear with cytoplasmic
Kmonickova V, Frolikova M, Steger K, Komrskova K.   +3 more
europepmc   +5 more sources

Life outside the LINC complex - Do SUN proteins have LINC-independent functions? [PDF]

Bioessays
AbstractSad1 and UNC84 (SUN) and Klarsicht, ANC‐1, and Syne homology (KASH) proteins interact at the nuclear periphery to form the linker of nucleoskeleton and cytoskeleton (LINC) complex, spanning the nuclear envelope (NE) and connecting the cytoskeleton with the nuclear interior.
Belaadi N, Guilluy C.
europepmc   +4 more sources

Molecular insights into LINC complex architecture through the crystal structure of a luminal trimeric coiled-coil domain of SUN1 [PDF]

Frontiers in Cell and Developmental Biology, 2023
The LINC complex, consisting of interacting SUN and KASH proteins, mechanically couples nuclear contents to the cytoskeleton. In meiosis, the LINC complex transmits microtubule-generated forces to chromosome ends, driving the rapid chromosome movements ...
Manickam Gurusaran, Jelle J. Biemans, Christopher W. Wood, Owen R. Davies   +3 more
doaj   +2 more sources