Results 11 to 20 of about 8,120 (205)

The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate. [PDF]

J Biol Eng, 2019
Mesenchymal stem cells (MSCs) show tremendous promise as a cell source for tissue engineering and regenerative medicine, and are understood to be mechanosensitive to external mechanical environments. In recent years, increasing evidence points to nuclear
Bouzid T, Kim E, Riehl BD, Esfahani AM, Rosenbohm J, Yang R, Duan B, Lim JY.   +7 more
europepmc   +7 more sources

The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal. [PDF]

Sci Rep, 2021
The morphology of the Golgi complex is influenced by the cellular context, which strictly correlates with nuclear functions; however, the mechanism underlying this association remains elusive.
Hieda M, Matsumoto T, Isobe M, Kurono S, Yuka K, Kametaka S, Wang JY, Chi YH, Kameda K, Kimura H, Matsuura N, Matsuura S.   +11 more
europepmc   +3 more sources

LINC complex alterations are a key feature of sporadic and familial ALS/FTD. [PDF]

Acta Neuropathol Commun
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects motor neurons, leading to progressive muscle weakness and loss of voluntary muscle control. While the exact cause of ALS is not fully understood, emerging research
Sirtori R, J Gregoire M, M Potts E, Collins A, Donatelli L, Fallini C.   +5 more
europepmc   +3 more sources

The plant LINC complex at the nuclear envelope. [PDF]

Chromosome Research, 2014
International audienceSignificant advances in understanding the plant nuclear envelope have been made over the past few years; indeed, knowledge of the protein network at the nuclear envelope is rapidly growing.
David E. Evans, Tatout, C, Emmanuel Vanrobays, Evans, D, Graumann, Katja, Graumann, K, Aline V. Probst, Tatout, Christophe, Katja Graumann, Probst, Aline V, Christophe Tatout, Evans, David E, Probst, A, Evans, David, E., Vanrobays, Emmanuel, Vanrobays, E   +15 more
core   +4 more sources

The LINC complex and human disease

Biochemical Society Transactions, 2011
The LINC (linker of nucleoskeleton and cytoskeleton) complex is a proposed mechanical link tethering the nucleo- and cyto-skeleton via the NE (nuclear envelope).
Peter Meinke, Manfred S. Wehnert, Thuy Duong Nguyen   +2 more
core   +3 more sources

Implications for Diverse Functions of the LINC Complexes Based on the Structure [PDF]

Cells, 2017
The linker of nucleoskeleton and cytoskeleton (LINC) complex is composed of the outer and inner nuclear membrane protein families Klarsicht, Anc-1, and Syne homology (KASH), and Sad1 and UNC-84 (SUN) homology domain proteins.
Miki Hieda
doaj   +3 more sources

LINC complexes in health and disease [PDF]

Nucleus, 2010
The cell nucleus communicates with the rest of the cell via nucleo/cytoplasmic transport of proteins and RNA through the nuclear pores. Direct mechanical links between the nucleus and the cytoplasm have recently emerged in the form of LINC (LInkers of ...
Misteli, Tom, Mejat, Alexandre
core   +6 more sources

The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity

eLife, 2019
Here we show that a major muscle specific isoform of the murine LINC complex protein SUN1 is required for efficient muscle regeneration. The nucleoplasmic domain of the isoform specifically binds to and inhibits Drosha, a key component of the ...
Tsui Han Loo, Xiaoqian Ye, Ruth Jinfen Chai, Mitsuteru Ito, Gisèle Bonne, Anne C Ferguson-Smith, Colin L Stewart   +6 more
doaj   +3 more sources

Mechanotransduction via the LINC complex regulates DNA replication in myonuclei [PDF]

Journal of Cell Biology, 2018
Nuclear mechanotransduction has been implicated in the control of chromatin organization; however, its impact on functional contractile myofibers is unclear.
Talila Volk, Barak Markus, Unnikannan CP, Elly Ordan, Elizabeth Stoops, Shuoshuo Wang, Adriana Reuveny   +6 more
core   +3 more sources

Functional Analysis of LINC Complexes in the Skin

, 2018
The genome in eukaryotic cells is encased by two intricate and interconnected concentric membranes, which together with the underlying nuclear lamina form the nuclear envelope (NE).
Iakowos Karakesisoglou, Karakesisoglou, Iakowos, Noegel, Angelika A., Carmen Mroß, Angelika A. Noegel, Mroß, Carmen   +5 more
core   +3 more sources