Results 1 to 10 of about 111,707 (190)

PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina [PDF]

Nucleus, 2023
The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery.
Anna A. Kiseleva, Yu-Chia Cheng, Cheryl L. Smith, Richard A. Katz, Andrey Poleshko   +4 more
doaj   +2 more sources

Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions [PDF]

Frontiers in Cell and Developmental Biology, 2022
Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic ...
Julia Madsen-Østerbye, Aurélie Bellanger, Natalia M. Galigniana, Natalia M. Galigniana, Philippe Collas, Philippe Collas   +5 more
doaj   +2 more sources

Nuclear shapes are geometrically determined by the excess surface area of the nuclear lamina [PDF]

Frontiers in Cell and Developmental Biology, 2023
Introduction: Nuclei have characteristic shapes dependent on cell type, which are critical for proper cell function, and nuclei lose their distinct shapes in multiple diseases including cancer, laminopathies, and progeria.
Richard B. Dickinson, Tanmay P. Lele, Tanmay P. Lele, Tanmay P. Lele   +3 more
doaj   +2 more sources

Baculoviruses exploit the mitotic kinase CDK1 to disrupt the nuclear lamina. [PDF]

PLoS Pathogens
The nuclear lamina is disassembled during mitosis, and certain DNA viruses exploit this process to facilitate replication. While we previously showed that baculoviruses disrupt the exogenously integrated lamina, their impact on the endogenous structure ...
Mei Mo, Silan Yu, Yushan Yang, Jiongjiong Liu, Kai Yang, Meijin Yuan   +5 more
doaj   +2 more sources

Mapping the micro-proteome of the nuclear lamina and lamina-associated domains [PDF]

Life Science Alliance, 2021
The nuclear lamina provides structure to the nucleus and serves as an interface between the cytoskeleton and large heterochromatin domains called LADs. This study describes the microproteome of this LAD/lamina interface.
Xianrong Wong, Jevon A Cutler, Victoria E Hoskins, Molly Gordon, Anil K Madugundu, Akhilesh Pandey, Karen L Reddy   +6 more
doaj   +4 more sources

Extreme wrinkling of the nuclear lamina is a morphological marker of cancer [PDF]

npj Precision Oncology
Nuclear atypia is a hallmark of cancer. A recent model posits that excess surface area, visible as folds/wrinkles in the lamina of a rounded nucleus, allows the nucleus to take on diverse shapes with little mechanical resistance.
Ting-Ching Wang, Christina R. Dollahon, Sneha Mishra, Hailee Patel, Samere Abolghasemzade, Ishita Singh, Vilmos Thomazy, Daniel G. Rosen, Vlad C. Sandulache, Saptarshi Chakraborty, Tanmay P. Lele   +10 more
doaj   +2 more sources

The nuclear lamina binds the EBV genome during latency and regulates viral gene expression [PDF]

PLoS Pathogens, 2022
The Epstein Barr virus (EBV) infects almost 95% of the population worldwide. While typically asymptomatic, EBV latent infection is associated with several malignancies of epithelial and lymphoid origin in immunocompromised individuals.
Lisa Beatrice Caruso, Rui Guo, Kelsey Keith, Jozef Madzo, Davide Maestri, Sarah Boyle, Jason Wasserman, Andrew Kossenkov, Benjamin E. Gewurz, Italo Tempera   +9 more
doaj   +3 more sources

3D Single Molecule Super-Resolution Microscopy of Whole Nuclear Lamina [PDF]

Frontiers in Chemistry, 2022
Single molecule (SM) super-resolution microscopies bypass the diffraction limit of conventional optical techniques and provide excellent spatial resolutions in the tens of nanometers without overly complex microscope hardware.
Ashley M. Rozario, Ashley M. Rozario, Alison Morey, Cade Elliott, Brendan Russ, Donna R. Whelan, Stephen J. Turner, Toby D. M. Bell   +7 more
doaj   +2 more sources

The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress. [PDF]

PLoS Pathogens, 2016
The nuclear lamina lines the inner nuclear membrane providing a structural framework for the nucleus. Cellular processes, such as nuclear envelope breakdown during mitosis or nuclear export of large ribonucleoprotein complexes, are functionally linked to
Jens Milbradt, Corina Hutterer, Hanife Bahsi, Sabrina Wagner, Eric Sonntag, Anselm H C Horn, Benedikt B Kaufer, Yasuko Mori, Heinrich Sticht, Torgils Fossen, Manfred Marschall   +10 more
doaj   +1 more source

Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes. [PDF]

, 2020
The nucleus of oocytes (germinal vesicle) is unusually large and its nuclear envelope (NE) is densely packed with nuclear pore complexes (NPCs) stockpiled for embryonic development. We showed that breakdown of this specialized NE is mediated by an Arp2/3-
Avilov, I., Geiss, C., Kondo, H., Lenart, P., Machado, P., Mori, M., Wesolowska, N.   +6 more
core   +1 more source