The intriguing plant nuclear lamina [PDF]
Frontiers in Plant Science, 2014 The nuclear lamina is a complex protein mesh attached to the inner nuclear membrane, which is also associated with nuclear pore complexes. It provides mechanical support to the nucleus and nuclear envelope, and as well as facilitating the connection of ...
Malgorzata eCiska +1 more
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Role of the Nuclear Lamina in Age-Associated Nuclear Reorganization and Inflammation [PDF]
Cells, 2020 Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues.
Lidya Kristiani, Miri Kim, Youngjo Kim
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Defective Nuclear Lamina in Aneuploidy and Carcinogenesis [PDF]
Frontiers in Oncology, 2018 Aneuploidy, loss or gain of whole chromosomes, is a prominent feature of carcinomas, and is generally considered to play an important role in the initiation and progression of cancer.
Elizabeth R. Smith +3 more
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PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina [PDF]
Nucleus, 2023 The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery.
Anna A. Kiseleva +4 more
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Structural and Mechanical Aberrations of the Nuclear Lamina in Disease
Cells, 2020 The nuclear lamins are the major components of the nuclear lamina in the nuclear envelope. Lamins are involved in numerous functions, including a role in providing structural support to the cell and the mechanosensing of the cell.
Merel Stiekema +3 more
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Nuclear shapes are geometrically determined by the excess surface area of the nuclear lamina [PDF]
Frontiers in Cell and Developmental Biology, 2023 Introduction: Nuclei have characteristic shapes dependent on cell type, which are critical for proper cell function, and nuclei lose their distinct shapes in multiple diseases including cancer, laminopathies, and progeria.
Richard B. Dickinson +3 more
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Mapping the micro-proteome of the nuclear lamina and lamina-associated domains [PDF]
Life Science Alliance, 2021 The nuclear lamina provides structure to the nucleus and serves as an interface between the cytoskeleton and large heterochromatin domains called LADs. This study describes the microproteome of this LAD/lamina interface.
Xianrong Wong +6 more
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The Nuclear Lamina: Protein Accumulation and Disease [PDF]
Biomedicines, 2020 Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging.
Carla Almendáriz-Palacios +7 more
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Baculoviruses exploit the mitotic kinase CDK1 to disrupt the nuclear lamina. [PDF]
PLoS PathogensThe nuclear lamina is disassembled during mitosis, and certain DNA viruses exploit this process to facilitate replication. While we previously showed that baculoviruses disrupt the exogenously integrated lamina, their impact on the endogenous structure ...
Mei Mo +5 more
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Extreme wrinkling of the nuclear lamina is a morphological marker of cancer [PDF]
npj Precision OncologyNuclear atypia is a hallmark of cancer. A recent model posits that excess surface area, visible as folds/wrinkles in the lamina of a rounded nucleus, allows the nucleus to take on diverse shapes with little mechanical resistance.
Ting-Ching Wang +10 more
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