The intriguing plant nuclear lamina [PDF]
Frontiers in Plant Science, 2014 The nuclear lamina is a complex protein mesh attached to the inner nuclear membrane, which is also associated with nuclear pore complexes. It provides mechanical support to the nucleus and nuclear envelope, and as well as facilitating the connection of ...
Malgorzata eCiska +1 more
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Role of the Nuclear Lamina in Age-Associated Nuclear Reorganization and Inflammation [PDF]
Cells, 2020 Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues.
Lidya Kristiani, Miri Kim, Youngjo Kim
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PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina [PDF]
Nucleus, 2023 The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery.
Anna A. Kiseleva +4 more
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Structural and Mechanical Aberrations of the Nuclear Lamina in Disease [PDF]
Cells, 2020 The nuclear lamins are the major components of the nuclear lamina in the nuclear envelope. Lamins are involved in numerous functions, including a role in providing structural support to the cell and the mechanosensing of the cell.
Merel Stiekema +3 more
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Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions [PDF]
Frontiers in Cell and Developmental Biology, 2022 Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic ...
Julia Madsen-Østerbye +5 more
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A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus [PDF]
Cell Reports, 2018 Summary: Tcrb locus V(D)J recombination is regulated by positioning at the nuclear periphery. Here, we used DamID to profile Tcrb locus interactions with the nuclear lamina at high resolution.
Shiwei Chen +7 more
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3D Single Molecule Super-Resolution Microscopy of Whole Nuclear Lamina [PDF]
Frontiers in Chemistry, 2022 Single molecule (SM) super-resolution microscopies bypass the diffraction limit of conventional optical techniques and provide excellent spatial resolutions in the tens of nanometers without overly complex microscope hardware.
Ashley M. Rozario +7 more
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Nuclear shapes are geometrically determined by the excess surface area of the nuclear lamina [PDF]
Frontiers in Cell and Developmental Biology, 2023 Introduction: Nuclei have characteristic shapes dependent on cell type, which are critical for proper cell function, and nuclei lose their distinct shapes in multiple diseases including cancer, laminopathies, and progeria.
Richard B. Dickinson +3 more
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Baculoviruses exploit the mitotic kinase CDK1 to disrupt the nuclear lamina. [PDF]
PLoS PathogensThe nuclear lamina is disassembled during mitosis, and certain DNA viruses exploit this process to facilitate replication. While we previously showed that baculoviruses disrupt the exogenously integrated lamina, their impact on the endogenous structure ...
Mei Mo +5 more
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Extreme wrinkling of the nuclear lamina is a morphological marker of cancer [PDF]
npj Precision OncologyNuclear atypia is a hallmark of cancer. A recent model posits that excess surface area, visible as folds/wrinkles in the lamina of a rounded nucleus, allows the nucleus to take on diverse shapes with little mechanical resistance.
Ting-Ching Wang +10 more
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